Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

We investigated whether treatment with LDE-paclitaxel changes plaque progression by coronary CT angiography and is safe in patients with chronic coronary artery disease. Analysis of inflammatory biomarkers and coronary CTA was also performed at baseline and 4 weeks after treatment.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

DAIC

DECEMBER 13, 2023

MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE.

Heart Attack 105

Heart Attack Heart attacks Atherosclerosis Stroke 105

Journal of the American Heart Association

JANUARY 12, 2024

ABSTRACT: Albuminuria, an established biomarker of the progression of chronic kidney disease, is also recognized as a biomarker for the risk of cardiovascular disease. Elevated urinary albumin excretion indicates kidney damage and systemic vascular disease, including myocardial capillary disease and arterial stiffness.

Cardiovascular Disease 71

Cardiovascular Disease Risk Factors Coronary Artery Disease Kidney Disease 71

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants. If delaying the onset of major chronic disease is your goal. Timing Matters.

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

DAIC

JUNE 4, 2024

I am excited about the potential of the FAI-Score biomarker, which has promising prognostic value beyond existing CT-based methods such as plaque, calcium scoring, and CAD-RADS based interpretation." Details of the study, included in a written statement issued by Caristo Diagnostics, follow. fold higher risk for cardiac mortality and 5.5-fold

Technology 116

Technology Heart Attack Heart attacks Coronary Artery Disease 116

Cardiovascular Diabetology

FEBRUARY 19, 2024

The triglyceride-glucose (TyG) index is considered a dependable biomarker for gauging insulin resistance. The atherogenic index of plasma (AIP) represents a marker reflecting atherosclerosis. However, there is.

Coronary Artery Disease 52

Coronary Artery Disease Atherosclerosis Biomarkers Research 52

European Journal of Heart Failure

OCTOBER 5, 2023

In this study, two independent cohorts were used to investigate for cardiovascular magnetic resonance (CMR) and genetic features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). NI-LGE was associated with adverse left ventricular remodelling but was not an independent prognostic indicator.

Coronary Artery Disease 40

Coronary Artery Disease Cardiomyopathy Outcomes Myocardial Infarction 40

Frontiers in Cardiovascular Medicine

OCTOBER 13, 2024

ObjectiveThe present study aimed at evaluating the association between sympathetic nervous system activation (SNS) and the severity of coronary artery disease (CAD).

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Atherosclerosis Biomarkers Coronary Artery Disease 52

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

CardiacWire

JANUARY 24, 2024

CardioSignal has already developed digital biomarkers for AFib and heart failure, while more solutions could be on the way for aortic stenosis, coronary artery disease, and pulmonary artery hypertension.

AFIB 75

AFIB Coronary Artery Disease Biomarkers Heart Failure 75

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2025

Abnormal stress biomarkers [regional wall motion abnormalities (RWMAs), ST-segment depression, induced angina, peak systolic blood pressure, force-based contractile reserve (CR), heart rate reserve (HRR), and low exercise capacity] were used for phenotyping.

Chest Pain 52

Chest Pain Exercise Angina Coronary Artery Disease 52

Frontiers in Cardiovascular Medicine

FEBRUARY 13, 2024

Furthermore, in the multivariable logistic regression, we identified potential risk factors for myocardial injury in Omicron variant–infected elderly patients, including advanced age, pre-existing coronary artery disease, interleukin-6 > 22.69

Risk Factors 64

Risk Factors Laboratory Coronary Artery Disease Cerebrovascular Disease 64

Dr. Paddy Barrett

OCTOBER 11, 2024

Inflammation is a key driver of heart disease, specifically coronary artery disease. I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process.

Obesity 81

Obesity Cancer Dementia Coronary Artery Disease 81

Circulation

JANUARY 15, 2024

Nevertheless, the relationship between CAC and the susceptibility of a plaque to provoke a thrombotic event remains incompletely understood.

Coronary Artery Disease 45

Coronary Artery Disease Atherosclerosis Laboratory Plaque 45

Stroke Journal

JANUARY 30, 2025

Patients with increasing CT-CSVD scores were older (p<0.001), more likely to have hypertension (p<0.001), diabetes (p<0.001), coronary artery disease (p=0.044), and a higher baseline systolic blood pressure (p=0.037). 1.02; score 2: OR 0.46, 95%CI 0.26-0.83; 0.83; score 3: OR 0.16, 95%CI 0.03-0.76,

Thrombolysis 40

Thrombolysis Outcomes Biomarkers Stroke 40

Dr. Paddy Barrett

SEPTEMBER 13, 2024

Even having one of the metabolic syndrome factors increases the risk of dying from heart disease by 73% 4. Having 3 of them while also having type 2 diabetes and existing coronary artery disease increases the risk of dying from heart disease by almost 8 fold. No fancy tests. No expensive scans.

Risk Factors 106

Risk Factors Heart Disease Dementia Diabetes 106

Coronary Artery Disease Journal

OCTOBER 30, 2023

Introduction Several blood inflammatory markers, such as high-sensitivity C-reactive protein (hs-CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), are linked to increased risk for cardiovascular diseases.

Cardiac Rehabilitation 52

Cardiac Rehabilitation Heart Disease Biomarkers Cardiovascular Disease 52

Circulation

NOVEMBER 11, 2024

Introduction:Inflammation plays an important role in the pathogenesis of coronary artery disease and Acute Coronary Syndrome (ACS). Conclusion:The SIRI and SII are inflammatory biomarkers that should be studied as potentially predictors of MACE among patients presented with ACS.

Angina 40

Angina Coronary Artery Disease Biomarkers Atherosclerosis 40

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. In my experience, some patients present later in life with a significantly elevated Lp(a) but have no evidence of coronary artery disease. This is the case with an elevated Lp(a).

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

European Journal of Heart Failure

SEPTEMBER 26, 2023

Natriuretic peptides (NPs) have been recognized as important biomarkers for diagnosing heart failure. diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk.

Heart Failure 40

Heart Failure Coronary Artery Disease Outpatient Document 40

Stroke Journal

FEBRUARY 1, 2024

Multivariable analyses adjusting for age, education, diabetes mellitus, coronary artery disease, alcohol use, ICH volume, and intraventricular hemorrhage showed that overweight, but not underweight or obese, subjects had higher odds of favorable outcome on discharge in the deep (OR 3.16, 95% CI 1.36-7.34) 5.94) groups.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Circulation

NOVEMBER 11, 2024

Mean patient age was 55 yrs, 56% (n=575) were women, and comorbid conditions were frequent: hypertension (64.1%), dyslipidemia (46.1%), diabetes (25.7%), documented coronary artery disease (19.3%), previous revascularization (20.6%), previous myocardial infarction (10.1%). Length of stay (LOS) in the CPU to discharge was 10.4

Chest Pain 40

Chest Pain ACE Inhibitor Cardiac Function Coronary Artery Disease 40

Dr. Anish Koka

MAY 16, 2023

Diamond and Forrester accomplished this by first establishing the prevalence of coronary artery disease based on how clinically likely patients with chest pain symptoms were found to have coronary disease based on a coronary angiogram. Thanks for reading Dr. Anish Koka's Newsletter! This happens.

Chest Pain 52

Chest Pain Coronary Artery Disease Cancer Heart Attack 52

Coronary Artery Disease Journal

NOVEMBER 26, 2023

Current imaging and plasma biomarkers provide delayed readouts of myocardial injury and recovery. Conclusion Analysis of miR release after STEMI identifies biomarkers that predict both acute and late outcomes after STEMI.

Myocardial Infarction 40

Myocardial Infarction STEMI Biomarkers Outcomes 40

Coronary Artery Disease Journal

NOVEMBER 1, 2023

Left ventricular ejection fraction was lower in TTS patients, but SCAD patients showed higher cardiac biomarkers. Precipitating triggers were more frequent in TTS patients, while emotional triggers and depressive disorders were more common in the SCAD group. In-hospital events (43.3% vs. 5.2%, P<0.01) occurred more frequently in TTS patients.

SCAD 52

SCAD Outcomes Risk Factors Atrial Fibrillation 52

European Journal of Heart Failure

JANUARY 21, 2024

These differences remained significant even after adjusting for age, gender, body mass index, history of diabetes mellitus, arterial hypertension, and coronary artery disease. Our study showed SGLT2 gene and protein hyper-expression in patients with LF-LG AS, compared to controls and HG AS ( p  < 0.05).

Stenosis 40

Stenosis Aortic Aortic valve Coronary Artery Disease 40

Dr. Paddy Barrett

AUGUST 22, 2023

Subscribe now APOE4 & Cardiovascular Risk We now know that carriers of APOE4 typically have higher circulating APOB levels, but the question is how much this influences the risk of cardiovascular disease. The association of apolipoprotein-E ( APOE ) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

DAIC

APRIL 9, 2024

Diabetic cardiomyopathy is a disease in which chronically high levels of blood glucose (hyperglycemia) damage the heart muscle, leading to heart failure over time. It’s estimated that about 1 in 5 people with diabetes have diabetic cardiomyopathy, although they may not be aware of it because initially the condition has no symptoms.

Heart Failure 52

Heart Failure Diabetes Cardiomyopathy Exercise 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

They are also at an increased risk of coronary artery disease (Discussed in more detail here ). Additionally, access to cholesterol synthesis biomarker testing, including desmosterol and lathosterol levels, can be challenging to obtain. This one requires some nuance. My approach for APOE 4 patients. J Lipid Res.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Stroke Journal

JANUARY 30, 2025

AFib diagnosis is critical to optimize secondary prevention and reduce the recurrent stroke risk.Objectives:We undertook an exploratory cross-platform proteomics study to discover plasma biomarkers of AFib diagnosis in patients with IS or transient ischemic attack (TIA).Methods:We

Biomarkers 40

Biomarkers AFIB Atrial Fibrillation Stroke 40

Circulation: Cardiovascular Imaging

FEBRUARY 19, 2024

18F-flourodeoxyglucose resting amygdalar uptake, an imaging biomarker of stress-related neural activity, coronary inflammation (fat attenuation index), and high-risk plaque characteristics were assessed by coronary computed tomography angiography. versus 5.1%; adjusted hazard ratio, 3.62 [95% CI, 1.14–17.14];P=0.039)

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Biomarkers 40

Physiologically Speaking

APRIL 24, 2024

9 Adults who sleep <6 hours each night have a 15% greater risk for CVD and 23% increased risk for coronary heart disease compared to those sleeping 7 hours or more. 12 Sleep duration is not only associated with diseases of the cardiovascular system, but also with direct biological markers of CVD risk.

Blood Pressure 52

Blood Pressure Blood Clot COVID-19 Cardiovascular Disease 52

Physiologically Speaking

DECEMBER 17, 2024

Data collection involved cardiac CT scans to measure CAC, blood biomarkers for cardiovascular health, dietary intake, and lifelong training history. Athletes with a family history of coronary artery disease had a 174% greater risk of CAC ≥100 and a staggering 335% increased risk of CAC ≥400.

Risk Factors 105

Risk Factors Genetic predisposition Plaque Exercise 105