Biomarkers, Circulation and Pulmonary

Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling

Frontiers in Cardiovascular Medicine

JANUARY 28, 2025

ObjectiveClinical practice currently faces a significant shortfall in specific biomarkers needed for diagnosing right ventricular (RV) remodeling in patients with pulmonary hypertension (PH). MiRNA sequencing analyses revealed 19 dif-miRNAs (12 upregulated and 7 downregulated) between the two groups.

Biomarkers

Biomarkers Circulation Heart Failure Pulmonary

Tenax Therapeutics Announces New U.S. Patent Covering the Use of Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

DAIC

MAY 6, 2024

Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,

Preserved Ejection Fraction

Preserved Ejection Fraction Heart Failure Pulmonary Hypertension

Abstract 4144785: Identification of ARMCX3 as potential mitochondria-related biomarker for pulmonary arterial hypertension using integrated bioinformatics analysis and machine learning

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144785-A4144785, November 12, 2024. Background:Acquired mitochondrial dysfunction is one of the characteristics of pulmonary arterial hypertension (PAH). Exploring potential biomarkers from mitochondrial perspective may be effective in the diagnosis and treatment of PAH.

Biomarkers

Biomarkers Pulmonary Hypertension Circulation

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension

Circulation

JANUARY 12, 2024

Circulation, Ahead of Print. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). Blood samples were collected for biomarker examination from healthy donors or patients with hypoxic PH.

Pulmonary

Pulmonary Hypertension Biomarkers Circulation

Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

Frontiers in Cardiovascular Medicine

APRIL 5, 2024

Inhaled NO has the unique ability to exert its vasodilatory effects in the pulmonary vasculature without any hypotensive side-effects in the systemic circulation. We will move on to the popular use of inhaled NO and will talk about the evidence base of the use of this selective pulmonary vasodilator.

Pediatrics

Pediatrics Pulmonary Biomarkers Innovation

Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease–Related Pulmonary Arterial Hypertension

Journal of the American Heart Association

NOVEMBER 28, 2023

Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Transpulmonary exosomal miRs offer valuable insights into pulmonary circulation microenvironments. Using an in vitro flow model simulating the shear stress experienced by pulmonary endothelial cells, we observed a significant upregulation of miR‐21.

Congenital Heart Disease

Congenital Heart Disease Congenital Pulmonary Heart Disease

Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta

Circulation: Heart Failure

MARCH 5, 2025

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Exercise-induced hypertension (EIH) is common in adults with coarctation of the aorta (COA), but there are limited data about hemodynamics and outcomes in such patients.

Exercise

Exercise Hypertension Outcomes Biomarkers

Abstract 4142484: Mechanism of miR-203a-3p regulating the proliferation and migration of PASMCs through PIK3CA/PI3K/Akt pathway in PAH

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142484-A4142484, November 12, 2024. Background:Pulmonary arterial hypertension (PAH) is characterized by an elevation in pulmonary vascular resistance and arterial pressure, culminating in right ventricular failure and mortality.

Pulmonary

Pulmonary Hypertension Biomarkers Circulation

Abstract 4142231: Relationship between serum interleukin-6 levels and severity of STEMI undergoing percutaneous coronary intervention

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4142231-A4142231, November 12, 2024. Blood samples for biomarker analyses, including IL-6, were collected.Results:There were 64 consecutive STEMI patients. All information about clinical and paraclinical parameters was recorded. There was 75% of males. The cut-off point was 14.9

STEMI

STEMI Myocardial Infarction Tricuspid Biomarkers

Persistent Chest Pain, an Elevated Troponin, and a Normal ECG. At midnight.

Dr. Smith's ECG Blog

DECEMBER 14, 2016

The patient had been on a long drive, suggesting possible pulmonary embolism (this was unlikely given absence of tachyardia, hypoxia, or any other feature of PE), so we sent a d dimer. [We The 4th, after the opening of the artery and release of troponin from the cardiac circulation, was 99.9 ng/mL So this was a very large MI!!

Chest Pain

Chest Pain STEMI Aortic Myocardial Infarction

Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research

DAIC

MAY 8, 2024

Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arterial hypertension (PAH). The research team delivered sFUS to cohorts of preclinical models with the disease.

Ultrasound

Ultrasound Pulmonary Research Hypertension

Abstract 4146478: Women with Acute Heart Failure Have Lower Intracardiac Pressures than Men Despite Similar Symptoms, Physical Findings, and Biomarkers

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146478-A4146478, November 12, 2024. 38±11 mm Hg, p=0.03), pulmonary capillary wedge (22±8 vs. 25±8 mm Hg,p=0.07) were all significantly lower or trended lower in women despite similar cardiac index, and mixed venous oxygen saturations between men and women (Image 1).

Heart Failure

Heart Failure Biomarkers Pulmonary Bicuspid/Mitral

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Published Research kschukar Thu, 04/20/2023 - 11:12 Recently published (2016 – present) manuscripts utilizing STS data: Adult Cardiac Surgery, General Thoracic Surgery, Congenital Heart Surgery, and Intermacs/Pedimacs.

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Published Research

Society of Thoracic Surgeons - Research

APRIL 20, 2023

Institutional Coronary Artery Bypass Case Volumes and Outcomes European Journal of Heart Failure October 2023 Makoto Mori 1 Robotic Mitral Valve Repair for Degenerative Mitral Regurgitation The Annals of Thoracic Surgery August 2023 Carlos Diaz-Castrillion 2 Volume-Failure to Rescue Relationship in Acute Type A Aortic Dissections: An Analysis of The (..)

Research

Research Coronary Artery Bypass Graft Aortic valve Congenital

Chest pain followed by 6 days of increasing dyspnea -- what happened?

Dr. Smith's ECG Blog

FEBRUARY 26, 2025

Both reperfusion, as judged by the biomarker curve, and patency, as assessed by the angiogram, were correlated with the rapidity and depth of T wave inversion. Rupture can be either free wall rupture (causing tamponade) or septal rupture, causing ventricular septal defect with left to right flow and resulting pulmonary edema and shock.

Chest Pain

Chest Pain Pericarditis Myocardial Infarction Dementia

Cardiovascular Update

Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling

Tenax Therapeutics Announces New U.S. Patent Covering the Use of Levosimendan in Pulmonary Hypertension with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)

Abstract 4144785: Identification of ARMCX3 as potential mitochondria-related biomarker for pulmonary arterial hypertension using integrated bioinformatics analysis and machine learning

Webinars

ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension

Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence

Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease–Related Pulmonary Arterial Hypertension

Hemodynamics of Exercise-Induced Hypertension and Relationship to Outcomes in Adults With Coarctation of the Aorta

Abstract 4142484: Mechanism of miR-203a-3p regulating the proliferation and migration of PASMCs through PIK3CA/PI3K/Akt pathway in PAH

Abstract 4142231: Relationship between serum interleukin-6 levels and severity of STEMI undergoing percutaneous coronary intervention

Persistent Chest Pain, an Elevated Troponin, and a Normal ECG. At midnight.

Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research

Abstract 4146478: Women with Acute Heart Failure Have Lower Intracardiac Pressures than Men Despite Similar Symptoms, Physical Findings, and Biomarkers

Published Research

Published Research

Chest pain followed by 6 days of increasing dyspnea -- what happened?

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