Cardiovascular Diabetology

JANUARY 19, 2024

Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia.

Diabetes 69

Diabetes Circulation Biomarkers Heart Disease 69

Heart BMJ

SEPTEMBER 25, 2024

Background Integration of large proteomics and genetic data in population-based studies can provide insights into discovery of novel biomarkers and potential therapeutic targets for cardiometabolic diseases (CMD). We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD.

Circulation 52

Circulation Biomarkers Heart Failure Atrial Fibrillation 52

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

We evaluated the erythroblast derived protein erythroferrone (ERFE) as an ancillary biomarker for the diagnosis of acute decompensated heart failure (ADHF) in these comorbid subgroups in both Western and Asian populations. The diagnostic performance of ERFE is impaired in patients with AF but not patients with obesity.

Heart Failure 59

Heart Failure Circulation Obesity Atrial Fibrillation 59

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT).

Biomarkers 69

Biomarkers Transplant Circulation Research 69

HCPLive

MAY 25, 2024

Circulating antinephrin autoantibodies identified as reliable biomarkers for MCD and primary FSGS, enhancing diagnostic precision and monitoring of nephrotic syndromes.

Biomarkers 64

Biomarkers Circulation 64

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113047-A4113047, November 12, 2024. The top ten percent of commonly observed significant biomarkers were evaluated using four unique ML classifiers. The identified biomarkers served as potential indicators for early detection of CVDs.

Biomarkers 40

Biomarkers Cardiovascular Disease Circulation 40

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Here, we studied the vascular expression of the key angiogenic factors, VEGFα and its antagonist angiostatin, in Fabry α-GAL-Tg/KO mice and determined circulating VEGFα and angiostatin serum levels in patients with Fabry’s disease and healthy controls.

Aortic 69

Aortic Biomarkers Circulation 69

Circulation: Heart Failure

SEPTEMBER 12, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. Fasting blood samples collected at the time of the cardiopulmonary exercise test were used to assay obesity-related biomarkers. The largest effect size was seen with leptin, where a 1-SD higher leptin was associated with a 2.35 P<0.001).

Biomarkers 40

Biomarkers Exercise Obesity Preserved Ejection Fraction 40

Circulation

JULY 28, 2024

Circulation, Volume 150, Issue 5 , Page 390-392, July 30, 2024.

Heart Failure 49

Heart Failure Biomarkers Circulation 49

Circulation: Cardiovascular Quality & Outcomes

JANUARY 19, 2024

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Background:Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM).Methods:This

Biomarkers 40

Biomarkers Sudden Cardiac Death Coronary Artery Bypass Graft Cardiomyopathy 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144785-A4144785, November 12, 2024. Exploring potential biomarkers from mitochondrial perspective may be effective in the diagnosis and treatment of PAH. Background:Acquired mitochondrial dysfunction is one of the characteristics of pulmonary arterial hypertension (PAH).

Biomarkers 40

Biomarkers Pulmonary Hypertension Circulation 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and targeted treatments. In addition to tissue-specific effects, patients with sarcoidosis exhibited an 8-fold increase in circulating ILC1s, which correlated with treatment status. Thus, granuloma formation was not a generic molecular response.

Biomarkers 65

Biomarkers Circulation 65

The American Journal of Cardiology

JUNE 5, 2024

Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Carine E. Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V. Ruggles, Lars Wallentin, David J. Maron, Judith S.

Ischemia 40

Ischemia Circulation Biomarkers Research 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Stroke 40

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy.

Heart Transplant 64

Heart Transplant Transplant Biomarkers Technology 64

Circulation: Heart Failure

JANUARY 5, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. 0.61 [SD];P=0.01) was identified as a suitable biomarker candidate for ADHF and kynurenine (mean, 1.69±0.39 Additionally, symmetrical dimethylarginine (mean, 1.97±0.61

Heart Failure 40

Heart Failure Biomarkers Cardiomyopathy Circulation 40

Frontiers in Cardiovascular Medicine

OCTOBER 13, 2024

Systemic activation of the SNS was estimated through circulating levels of norepinephrine (NE). Elevated levels of circulating pro-inflammatory markers were significantly correlated with increased NE concentrations (for IL-1β: p < 0.001, r = 0.49; for IL-6 and NE: p = 0.003, r = 0.32; for HIF-1α and NE: p = 0.049, r = 0.21).

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Atherosclerosis Biomarkers Coronary Artery Disease 52

Circulation

DECEMBER 3, 2024

Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease.

Cardiovascular Disease 68

Cardiovascular Disease Cerebrovascular Disease Pharmacology Biomarkers 68

Circulation

DECEMBER 4, 2023

Circulation, Ahead of Print. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS:Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. 1.54), whereas it was 1.25 (95% CI, 1.16–1.33)

Cardiovascular Disease 75

Cardiovascular Disease Biomarkers Circulation 75

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146638-A4146638, November 12, 2024. Thus, levels above these thresholds for both apo B and hsCRP are associated with high ASCVD risk.Conclusion(s):The study demonstrates that apo B exhibits high discriminatory and diagnostic accuracy, making it a suitable ASCVD risk biomarker compared to hsCRP.

Biomarkers 40

Biomarkers Cardiovascular Disease Laboratory Plaque 40

Cardiovascular Diabetology

JUNE 20, 2024

Circulating atherogenic index of plasma (AIP) levels has been proposed as a novel biomarker for dyslipidemia and as a predictor of insulin resistance (IR) risk. However, the association between AIP and the inc.

Biomarkers 52

Biomarkers Circulation Stroke Strokes 52

Stroke Journal

FEBRUARY 1, 2024

Background:Increase in mean lesional iron content (≥6%) measurement by QSM and vascular permeability (≥ 40%) assessed by DCEQP MRI have been associated with new bleeding in cavernous angiomas (CA), and are used as monitoring biomarkers in clinical trial of pharmacotherapy in CAs with symptomatic hemorrhage (SH).

Biomarkers 40

Biomarkers Hemorrhage Circulation Stroke 40

Circulation: Heart Failure

OCTOBER 18, 2024

Circulation: Heart Failure, Ahead of Print.

Heart Failure 40

Heart Failure Biomarkers Circulation 40

Medical Xpress - Cardiology

JULY 2, 2024

At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk. Exercise testing can serve as a powerful physiologic probe to unmask subclinical cardiovascular abnormalities well before disease onset.

Hypertension 52

Hypertension Blood Pressure Exercise Biomarkers 52

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4136687-A4136687, November 12, 2024. These findings suggest that VTRNA2-1 promoter methylation status could serve as a valuable biomarker for predicting prognosis and guiding treatment strategies in PAD. 6.97, p=0.024), amputations (HR 2.58, 95% CI 1.02-6.57,

Peripheral Arterial Disease 40

Peripheral Arterial Disease Biomarkers Angioplasty Atherosclerosis 40

Frontiers in Cardiovascular Medicine

APRIL 5, 2024

Inhaled NO has the unique ability to exert its vasodilatory effects in the pulmonary vasculature without any hypotensive side-effects in the systemic circulation. NO is a cellular signaling molecule that induces smooth muscle relaxation in the mammalian vasculature.

Pediatrics 93

Pediatrics Pulmonary Biomarkers Innovation 93

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset.

Stroke 40

Stroke Strokes Thrombolysis Circulation 40

Circulation: Genomic and Precision Medicine

FEBRUARY 13, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print.

Cardiovascular Disease 40

Cardiovascular Disease Biomarkers Circulation 40

Heart BMJ

SEPTEMBER 25, 2024

Circulating proteins are the result of genetically inherited predispositions to diseases and the influences of environmental exposures, diet, lifestyle behaviours and the ageing process.

Diet 52

Diet Biomarkers Circulation 52

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2024

Inflammatory biomarkers were measured with the Meso Scale Discovery® platform, and kynurenine pathway metabolites were assessed using targeted metabolomic profiling conducted by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS). Methods Anti-apoA1 IgG levels were assessed by an in-house ELISA.

Biomarkers 49

Biomarkers Circulation Cardiovascular Disease 49

Science Daily - Heart Disease

NOVEMBER 28, 2023

A new study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites -- molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases.

Cardiovascular Disease 45

Cardiovascular Disease Biomarkers Circulation Research 45

Circulation

FEBRUARY 5, 2024

Circulation, Ahead of Print. A retrospective preeclampsia cohort study was performed to determine the value of circulating galectin-9 in predicting preeclampsia.RESULTS:We discovered a distinct CD11chighdMφ subset that inhibits spiral artery remodeling in preeclampsia.

Circulation 49

Circulation Biomarkers 49

Frontiers in Cardiovascular Medicine

JANUARY 4, 2024

Background The discovery of novel biomarkers that improve current cardiovascular risk prediction models of acute coronary syndrome (ACS) is needed for the identification of very high-risk patients and therapeutic decision-making.

Biomarkers 64

Biomarkers Circulation 64

DAIC

JANUARY 23, 2024

Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 2019 Sep 10;140(11):e649-e650] [published correction appears in Circulation. Circulation.

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Open Heart

MARCH 24, 2023

Novel approaches are developing to address this through: (1) screening with circulating biomarkers; (2) development of drugs to slow disease progression and (3) early valve intervention guided by medical imaging.

Stenosis 52

Stenosis Aortic Aortic valve Biomarkers 52

Circulation: Genomic and Precision Medicine

FEBRUARY 7, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:The circulating proteome may encode early pathways of diabetes susceptibility in young adults for surveillance and intervention.

Diabetes 40

Diabetes Biomarkers Circulation 40

Circulation

JANUARY 12, 2024

Circulation, Ahead of Print. Blood samples were collected for biomarker examination from healthy donors or patients with hypoxic PH. BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options.

Pulmonary 45

Pulmonary Hypertension Biomarkers Circulation 45