Circulation: Cardiovascular Quality & Outcomes

JANUARY 19, 2024

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Background:Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM).Methods:This

Biomarkers 40

Biomarkers Sudden Cardiac Death Coronary Artery Bypass Graft Cardiomyopathy 40

The American Journal of Cardiology

JUNE 5, 2024

Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Carine E. Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V. Ruggles, Lars Wallentin, David J. Maron, Judith S.

Ischemia 40

Ischemia Circulation Biomarkers Research 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

We evaluated the erythroblast derived protein erythroferrone (ERFE) as an ancillary biomarker for the diagnosis of acute decompensated heart failure (ADHF) in these comorbid subgroups in both Western and Asian populations. The diagnostic performance of ERFE is impaired in patients with AF but not patients with obesity.

Heart Failure 59

Heart Failure Circulation Obesity Atrial Fibrillation 59

Circulation

JULY 28, 2024

Circulation, Volume 150, Issue 5 , Page 390-392, July 30, 2024.

Heart Failure 49

Heart Failure Biomarkers Circulation 49

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Stroke 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and targeted treatments. In addition to tissue-specific effects, patients with sarcoidosis exhibited an 8-fold increase in circulating ILC1s, which correlated with treatment status. Thus, granuloma formation was not a generic molecular response.

Biomarkers 49

Biomarkers Circulation 49

HCPLive

MAY 25, 2024

Circulating antinephrin autoantibodies identified as reliable biomarkers for MCD and primary FSGS, enhancing diagnostic precision and monitoring of nephrotic syndromes.

Biomarkers 64

Biomarkers Circulation 64

Circulation: Heart Failure

JANUARY 5, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. 0.61 [SD];P=0.01) was identified as a suitable biomarker candidate for ADHF and kynurenine (mean, 1.69±0.39 Additionally, symmetrical dimethylarginine (mean, 1.97±0.61

Heart Failure 40

Heart Failure Biomarkers Cardiomyopathy Circulation 40

Cardiovascular Diabetology

JUNE 20, 2024

Circulating atherogenic index of plasma (AIP) levels has been proposed as a novel biomarker for dyslipidemia and as a predictor of insulin resistance (IR) risk. However, the association between AIP and the inc.

Biomarkers 52

Biomarkers Circulation Stroke Strokes 52

Stroke Journal

FEBRUARY 1, 2024

Background:Increase in mean lesional iron content (≥6%) measurement by QSM and vascular permeability (≥ 40%) assessed by DCEQP MRI have been associated with new bleeding in cavernous angiomas (CA), and are used as monitoring biomarkers in clinical trial of pharmacotherapy in CAs with symptomatic hemorrhage (SH).

Biomarkers 40

Biomarkers Hemorrhage Circulation Stroke 40

Medical Xpress - Cardiology

JULY 2, 2024

At present, there is no reliable circulating biomarker—a protein or other molecule present in the blood stream—indicative of hypertension risk. Exercise testing can serve as a powerful physiologic probe to unmask subclinical cardiovascular abnormalities well before disease onset.

Hypertension 52

Hypertension Blood Pressure Exercise Biomarkers 52

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Here, we studied the vascular expression of the key angiogenic factors, VEGFα and its antagonist angiostatin, in Fabry α-GAL-Tg/KO mice and determined circulating VEGFα and angiostatin serum levels in patients with Fabry’s disease and healthy controls.

Aortic 69

Aortic Biomarkers Circulation 69

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset.

Stroke 40

Stroke Strokes Circulation Thrombolysis 40

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy.

Heart Transplant 64

Heart Transplant Transplant Biomarkers Technology 64

Science Daily - Heart Disease

NOVEMBER 28, 2023

A new study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites -- molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases.

Cardiovascular Disease 47

Cardiovascular Disease Biomarkers Circulation Research 47

Circulation

DECEMBER 4, 2023

Circulation, Ahead of Print. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS:Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. 1.54), whereas it was 1.25 (95% CI, 1.16–1.33)

Cardiovascular Disease 75

Cardiovascular Disease Biomarkers Circulation 75

Circulation: Genomic and Precision Medicine

FEBRUARY 13, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print.

Cardiovascular Disease 40

Cardiovascular Disease Biomarkers Circulation 40

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2024

Inflammatory biomarkers were measured with the Meso Scale Discovery® platform, and kynurenine pathway metabolites were assessed using targeted metabolomic profiling conducted by liquid chromatography-multiple reaction monitoring/mass spectrometry (LC-MRM/MS). Methods Anti-apoA1 IgG levels were assessed by an in-house ELISA.

Biomarkers 64

Biomarkers Circulation Cardiovascular Disease 64

Circulation

FEBRUARY 5, 2024

Circulation, Ahead of Print. A retrospective preeclampsia cohort study was performed to determine the value of circulating galectin-9 in predicting preeclampsia.RESULTS:We discovered a distinct CD11chighdMφ subset that inhibits spiral artery remodeling in preeclampsia.

Circulation 49

Circulation Biomarkers 49

Circulation

JANUARY 12, 2024

Circulation, Ahead of Print. Blood samples were collected for biomarker examination from healthy donors or patients with hypoxic PH. BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options.

Pulmonary 45

Pulmonary Hypertension Biomarkers Circulation 45

Frontiers in Cardiovascular Medicine

JANUARY 4, 2024

Background The discovery of novel biomarkers that improve current cardiovascular risk prediction models of acute coronary syndrome (ACS) is needed for the identification of very high-risk patients and therapeutic decision-making.

Biomarkers 64

Biomarkers Circulation 64

Open Heart

MARCH 24, 2023

Novel approaches are developing to address this through: (1) screening with circulating biomarkers; (2) development of drugs to slow disease progression and (3) early valve intervention guided by medical imaging.

Stenosis 52

Stenosis Aortic Aortic valve Biomarkers 52

Frontiers in Cardiovascular Medicine

APRIL 5, 2024

Inhaled NO has the unique ability to exert its vasodilatory effects in the pulmonary vasculature without any hypotensive side-effects in the systemic circulation. NO is a cellular signaling molecule that induces smooth muscle relaxation in the mammalian vasculature.

Pediatrics 93

Pediatrics Pulmonary Biomarkers Innovation 93

Circulation

JANUARY 15, 2024

Circulation, Volume 149, Issue 3 , Page 251-266, January 16, 2024. Coronary artery calcification (CAC) accompanies the development of advanced atherosclerosis. Nevertheless, the relationship between CAC and the susceptibility of a plaque to provoke a thrombotic event remains incompletely understood.

Coronary Artery Disease 45

Coronary Artery Disease Atherosclerosis Laboratory Plaque 45

Circulation: Cardiovascular Imaging

DECEMBER 11, 2023

Circulation: Cardiovascular Imaging, Ahead of Print. In addition to the traditional clinical risk factors, an increasing amount of imaging biomarkers have shown value for cardiovascular risk prediction.

Cardiovascular Imaging 40

Cardiovascular Imaging Biomarkers Risk Factors Circulation 40

Circulation: Genomic and Precision Medicine

JANUARY 30, 2024

Circulation: Genomic and Precision Medicine, Ahead of Print. The discovery of new omics biomarkers could help to improve risk stratification algorithms and expand our understanding of molecular pathways contributing to the disease. BACKGROUND:Cardiovascular disease (CVD) is among the leading causes of death worldwide.

Cardiovascular Disease 40

Cardiovascular Disease Biomarkers Circulation Risk Factors 40

Circulation

OCTOBER 22, 2023

Circulation, Ahead of Print. of patients were female and 55% presented with biomarker positive ACS. Background:Dual antiplatelet therapy (DAPT) with a potent P2Y12Inhibitor coupled with aspirin for 1 year is the recommended treatment for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Biomarkers 40

Biomarkers Myocardial Infarction Academic Stroke 40

Stroke Journal

FEBRUARY 1, 2024

The cellular architecture in the lesions and their genetic alterations have not been elucidated, limiting biomarker development and therapeutic targeting. Further studies shall aim at confirming these findings in human CMB lesions, and their association with circulating molecules.

Biomarkers 40

Biomarkers Hemorrhage Stroke Strokes 40

Heart BMJ

JANUARY 10, 2024

Growth differentiation factor (GDF)-15 has emerged as a potentially useful biomarker. This study sought to identify determinants of circulating GDF-15 and evaluate its prognostic value, in patients at risk of HF or with HF but before first hospitalisation.

Heart Failure 52

Heart Failure Biomarkers Diabetes Outcomes 52

Circulation: Heart Failure

MARCH 1, 2024

Circulation: Heart Failure, Ahead of Print. Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. BACKGROUND:Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF).

Heart Failure 40

Heart Failure Preserved Ejection Fraction Risk Factors Atherosclerosis 40

Circulation

DECEMBER 22, 2023

Circulation, Ahead of Print. BACKGROUND:Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach to lower blood pressure (BP) but are not equally effective across all individuals.

Hypertension 45

Hypertension Blood Pressure Biomarkers Risk Factors 45

Journal of the American Heart Association

FEBRUARY 14, 2024

Predicted target genes of the 5 miRNAs were mapped to key hypertension pathways: lysine degradation, fatty acid biosynthesis, and metabolism.ConclusionsThe above identified circulating miRNAs may have a potential for clinical use as biomarkers for thiazide diuretic selection in hypertension.RegistrationURL:ClinicalTrials.gov.

Biomarkers 45

Biomarkers Circulation Hypertension Blood Pressure 45

Circulation: Heart Failure

OCTOBER 23, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023. BACKGROUND:Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Biomarkers Exercise 40

Circulation

FEBRUARY 23, 2024

Circulation, Ahead of Print. NPM1 may serve as a promising prognostic biomarker and a valuable therapeutic target for heart failure after MI.

Myocardial Infarction 45

Myocardial Infarction Cardiac Function Biomarkers Heart Failure 45

Journal of the American Heart Association

NOVEMBER 28, 2023

Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Transpulmonary exosomal miRs offer valuable insights into pulmonary circulation microenvironments. BackgroundPulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis.

Congenital Heart Disease 40

Congenital Heart Disease Congenital Pulmonary Heart Disease 40

Journal of the American Heart Association

NOVEMBER 23, 2023

The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. Mice lackingFxrandGpbar1−/−/Fxr−/−display hypotension and aortic inflammation, along with altered intestinal permeability that deteriorates with age, and severe dysbiosis, along with dysregulated bile acid synthesis.

Aortic 40

Aortic Aneurysm Plaque Cholesterol 40

DAIC

JANUARY 23, 2024

Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 2019 Sep 10;140(11):e649-e650] [published correction appears in Circulation. Circulation.

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111