Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. EVs were isolated from serum by precipitation.

Plaque 52

Plaque Biomarkers Circulation Stenosis 52

Frontiers in Cardiovascular Medicine

FEBRUARY 11, 2024

In this review, we summarize the diagnostic and prognostic tools for ICI-myocarditis, including electrocardiography, echocardiography, cardiac magnetic resonance imaging, with emphasis on circulating biomarkers.

Biomarkers 64

Biomarkers Circulation Cancer Outcomes 64

Circulation

DECEMBER 3, 2024

Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease.

Cardiovascular Disease 73

Cardiovascular Disease Cerebrovascular Disease Pharmacology Biomarkers 73

Med Page Today

NOVEMBER 11, 2024

(MedPage Today) -- A small panel of circulating biomarkers may reliably distinguish hypertrophic cardiomyopathy (HCM) from similar conditions that cause left ventricular hypertrophy (LVH), researchers found. From proteomic profiling of nearly.

Cardiomyopathy 116

Cardiomyopathy Biomarkers Circulation Research 116

Circulation: Heart Failure

MARCH 14, 2025

Circulation: Heart Failure, Ahead of Print. Cardiovascular biomarkers and multimodality imaging may identify initial amyloidogenic organ involvement. The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant.

Genetic predisposition 71

Genetic predisposition Heart Failure Biomarkers Circulation 71

HCPLive

JULY 30, 2024

Greater circulating Z-polymer levels were associated with an increased risk of adverse clinical outcomes in adults with AATD and the PiZZ genotype.

Circulation 52

Circulation Biomarkers Outcomes 52

Cardiovascular Diabetology

JANUARY 7, 2025

We aimed to investigate the relationship between circulating apoCIII levels and. Preclinical studies suggest that a triglyceride (TG)-independent proinflammatory action of apolipoprotein C-III (apoCIII) exists.

Circulation 52

Circulation Biomarkers Research 52

Circulation: Heart Failure

NOVEMBER 11, 2024

Circulation: Heart Failure, Ahead of Print. Using plasma proteomics profiling, we aimed to identify circulating biomarkers and dysregulated signaling pathways specific to HCM.Methods:In this multicenter case-control study, plasma proteomics profiling was performed in cases with HCM and controls with hypertensive LVH, ATTR-CM, and AS.

Cardiomyopathy 40

Cardiomyopathy Biomarkers Circulation Hypertension 40

Heart BMJ

SEPTEMBER 25, 2024

Background Integration of large proteomics and genetic data in population-based studies can provide insights into discovery of novel biomarkers and potential therapeutic targets for cardiometabolic diseases (CMD). We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD.

Circulation 52

Circulation Biomarkers Heart Failure Atrial Fibrillation 52

Cardiovascular Diabetology

JANUARY 19, 2024

Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia.

Diabetes 69

Diabetes Circulation Biomarkers Heart Disease 69

Stroke Journal

JANUARY 30, 2025

Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).

Biomarkers 40

Biomarkers Circulation Strokes Stroke 40

Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and targeted treatments. In addition to tissue-specific effects, patients with sarcoidosis exhibited an 8-fold increase in circulating ILC1s, which correlated with treatment status. Thus, granuloma formation was not a generic molecular response.

Biomarkers 80

Biomarkers Circulation 80

Hypertension Journal

DECEMBER 3, 2024

Colocalization analyses were then used to investigate whether the circulating proteins and blood pressure traits shared causal genetic variants.

Blood Pressure 40

Blood Pressure Circulation Hypertension Physiology 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

We evaluated the erythroblast derived protein erythroferrone (ERFE) as an ancillary biomarker for the diagnosis of acute decompensated heart failure (ADHF) in these comorbid subgroups in both Western and Asian populations. The diagnostic performance of ERFE is impaired in patients with AF but not patients with obesity.

Heart Failure 59

Heart Failure Circulation Obesity Atrial Fibrillation 59

Stroke Journal

JANUARY 30, 2025

We identify circulating proteomic signatures for ischemic stroke prognosis, and correlate these with clinical data to develop a proteomic profile of 14 markers. Conclusion:We identify potential biomarkers and therapeutic targets and offer an opportunity for more precise prognosis and treatment in ischemic stroke. AUC range:0.65-0.99).Conclusion:We

Biomarkers 40

Biomarkers Strokes Stroke Technology 40

HCPLive

MAY 25, 2024

Circulating antinephrin autoantibodies identified as reliable biomarkers for MCD and primary FSGS, enhancing diagnostic precision and monitoring of nephrotic syndromes.

Biomarkers 64

Biomarkers Circulation 64

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4113047-A4113047, November 12, 2024. The top ten percent of commonly observed significant biomarkers were evaluated using four unique ML classifiers. The identified biomarkers served as potential indicators for early detection of CVDs.

Biomarkers 40

Biomarkers Cardiovascular Disease Circulation 40

Circulation: Heart Failure

SEPTEMBER 12, 2023

Circulation: Heart Failure, Volume 16, Issue 11 , Page e010618, November 1, 2023. Fasting blood samples collected at the time of the cardiopulmonary exercise test were used to assay obesity-related biomarkers. The largest effect size was seen with leptin, where a 1-SD higher leptin was associated with a 2.35 P<0.001).

Biomarkers 40

Biomarkers Obesity Exercise Preserved Ejection Fraction 40

Circulation

JULY 28, 2024

Circulation, Volume 150, Issue 5 , Page 390-392, July 30, 2024.

Heart Failure 49

Heart Failure Biomarkers Circulation 49

Stroke Journal

JANUARY 30, 2025

It remains unclear if the biomarkers used in the trial reliably identified atrial cardiopathy. Multi-territorial infarction was defined as acute infarction in at least two of the left middle cerebral artery (MCA), right MCA, and posterior circulation. and Canada. 1.16), PTFV1 (OR per SD, 1.06; 95% CI, 0.98-1.15),

Biomarkers 40

Biomarkers Cardiomyopathy Strokes Stroke 40

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT).

Biomarkers 69

Biomarkers Transplant Circulation Research 69

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4144785-A4144785, November 12, 2024. Exploring potential biomarkers from mitochondrial perspective may be effective in the diagnosis and treatment of PAH. Background:Acquired mitochondrial dysfunction is one of the characteristics of pulmonary arterial hypertension (PAH).

Biomarkers 40

Biomarkers Pulmonary Hypertension Circulation 40

DAIC

FEBRUARY 3, 2025

This clearance comes in advance of disease-modifying therapies on the horizon expected to help clinicians use this biomarker to guide patients to improved cardiovascular health, saidBrad Moore, president and CEO at Roche Diagnostics North America. Circulation. The development of the Tina-quant Lipoprotein (a) Gen.2 Arnett DK et al.

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Circulation

MARCH 9, 2025

Circulation, Volume 151, Issue 10 , Page 716-732, March 11, 2025. Urinary albumin-to-creatinine ratio is an attractive, unifying biomarker of cardiovascular, kidney, and metabolic conditions that may be useful for identifying and monitoring disease trajectory.

Kidney Disease 83

Kidney Disease Biomarkers Heart Failure Risk Factors 83

The American Journal of Cardiology

JUNE 5, 2024

Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Carine E. Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V. Ruggles, Lars Wallentin, David J. Maron, Judith S.

Ischemia 40

Ischemia Circulation Biomarkers Research 40

Circulation: Heart Failure

JANUARY 16, 2025

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Right ventricular dysfunction (RVD) is common in patients with heart failure with reduced ejection fraction, and it is associated with poor prognosis.

Biomarkers 40

Biomarkers Heart Failure Heart Transplant Transplant 40

Science Daily - Heart Disease

NOVEMBER 28, 2023

A new study found that alcohol consumption may have counteractive effects on CVD risk, depending on the biological presence of certain circulating metabolites -- molecules that are produced during or after a substance is metabolized and studied as biomarkers of many diseases.

Cardiovascular Disease 65

Cardiovascular Disease Biomarkers Circulation Research 65

Circulation: Cardiovascular Interventions

MARCH 26, 2025

Circulation: Cardiovascular Interventions, Ahead of Print.

Biomarkers 40

Biomarkers Cardiovascular Interventions Circulation 40

Frontiers in Cardiovascular Medicine

OCTOBER 13, 2024

Systemic activation of the SNS was estimated through circulating levels of norepinephrine (NE). Elevated levels of circulating pro-inflammatory markers were significantly correlated with increased NE concentrations (for IL-1β: p < 0.001, r = 0.49; for IL-6 and NE: p = 0.003, r = 0.32; for HIF-1α and NE: p = 0.049, r = 0.21).

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Atherosclerosis Biomarkers Coronary Artery Disease 52

Circulation

DECEMBER 4, 2023

Circulation, Ahead of Print. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium.METHODS:Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. 1.54), whereas it was 1.25 (95% CI, 1.16–1.33)

Cardiovascular Disease 75

Cardiovascular Disease Biomarkers Circulation 75

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP6-ATP6, February 1, 2024. Background:Brain arteriovenous malformations (bAVMs) are an important cause of intracranial hemorrhage, seizure, or other neurological deficits. Clinical heterogeneity of bAVM suggests a role for genetic modifiers that may associate with seizure risk.

Circulation 40

Circulation Biomarkers Hemorrhage Strokes 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4146638-A4146638, November 12, 2024. Thus, levels above these thresholds for both apo B and hsCRP are associated with high ASCVD risk.Conclusion(s):The study demonstrates that apo B exhibits high discriminatory and diagnostic accuracy, making it a suitable ASCVD risk biomarker compared to hsCRP.

Biomarkers 40

Biomarkers Cardiovascular Disease Laboratory Plaque 40

Cardiovascular Diabetology

JUNE 20, 2024

Circulating atherogenic index of plasma (AIP) levels has been proposed as a novel biomarker for dyslipidemia and as a predictor of insulin resistance (IR) risk. However, the association between AIP and the inc.

Biomarkers 52

Biomarkers Circulation Strokes Stroke 52

Frontiers in Cardiovascular Medicine

FEBRUARY 5, 2024

Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy.

Heart Transplant 64

Heart Transplant Transplant Biomarkers Technology 64

Circulation: Heart Failure

JANUARY 5, 2024

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. 0.61 [SD];P=0.01) was identified as a suitable biomarker candidate for ADHF and kynurenine (mean, 1.69±0.39 Additionally, symmetrical dimethylarginine (mean, 1.97±0.61

Heart Failure 40

Heart Failure Biomarkers Cardiomyopathy Circulation 40

Stroke Journal

JANUARY 30, 2025

An imaging biomarker that more strongly correlates with post-EVT functional outcome would be helpful for clinical prognosis and serve as a surrogate outcome measure in trials of EVT-adjuvant therapies. Consecutive anterior circulation EVT patients were included from 2018-2019 who achieved successful reperfusion (mTICI 2b).

Biomarkers 40

Biomarkers Outcomes Circulation Strokes 40

Circulation: Cardiovascular Quality & Outcomes

NOVEMBER 14, 2024

Circulation: Cardiovascular Quality and Outcomes, Volume 17, Issue 12 , Page e011483, December 1, 2024.

Biomarkers 40

Biomarkers Circulation Outcomes 40