Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. Analysis of inflammatory biomarkers and coronary CTA was also performed at baseline and 4 weeks after treatment.

Coronary Artery Disease 59

Coronary Artery Disease Laboratory Plaque Myocardial Infarction 59

Journal of the American Heart Association

NOVEMBER 23, 2023

The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. Mice lackingFxrandGpbar1−/−/Fxr−/−display hypotension and aortic inflammation, along with altered intestinal permeability that deteriorates with age, and severe dysbiosis, along with dysregulated bile acid synthesis.

Aortic 40

Aortic Aneurysm Plaque Cholesterol 40

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 4 In the U.S.

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111