Remove Biomarkers Remove Cholesterol Remove Diabetes
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Abstract TMP119: Evaluation of Cognitive Function and Plasma Biomarkers in a Microemboli-Based VCID Model in Rats: Applying Clinical Recommendations From MarkVCID and the Lacunar Intervention Trial-2 (LACI-2) to a Preclinical Model

Stroke Journal

Diabetes doubles the risk of VCID. We showed that diabetic but not control rats develop a progressive cognitive decline in a microemboli (ME) model of VCID. Behavioral deficits observed in the untreated diabetic rats were not noted in the treated group. Some of the biomarkers were unchanged (Table).

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How To Reduce The Risk Of Heart Disease If You Have Insulin Resistance.

Dr. Paddy Barrett

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. On the far end of that line is type two diabetes. Insulin resistance and diabetes may not ‘ cause ’ coronary artery disease, but they are huge accelerants.

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Safety and possible anti-inflammatory effect of paclitaxel associated with LDL-like nanoparticles (LDE) in patients with chronic coronary artery disease: a double-blind, placebo-controlled pilot study

Frontiers in Cardiovascular Medicine

Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. Analysis of inflammatory biomarkers and coronary CTA was also performed at baseline and 4 weeks after treatment.

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Cardiovascular sequelae of trastuzumab and anthracycline in long-term survivors of breast cancer

Heart BMJ

Participants underwent clinical cardiovascular evaluation, ECG, cardiac biomarker evaluation and CMR. 58% had total cholesterol >5.0 mmol/L and 5% had a new diagnosis of diabetes. All participants had normal LVEF prior to, and on completion of, treatment. Median time since completion of trastuzumab was 7.8 years (range 5.9–10.8

Cancer 52
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American Heart Month Puts Spotlight on Cardiovascular Disease and Stroke Statistics

DAIC

.** According to the American Diabetes Association, cardiovascular disease (CVD), where the heart and blood vessels are negatively impacted, is the number one cause of death in people living with diabetes, resulting in 2/3 of deaths in people with type 2 diabetes. million have diagnosed diabetes; and 9.7 In addition, 115.9

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CLEAR Trial of Bempedoic Acid

All About Cardiovascular System and Disorders

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. There was no increase in new onset diabetes mellitus or worsening of diabetes mellitus. The manufacturers have reported that these clauses have been removed.

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Why Insulin Resistance Is The Biggest Silent Risk Factor For Heart Disease.

Dr. Paddy Barrett

Everyone sits somewhere on the scale of insulin sensitivity from very insulin sensitive to very insulin resistant at the point of type 2 diabetes. When insulin resistance progresses to type 2 diabetes, that risk increases to a 10-fold increase in risk. Low HDL Cholesterol. Measuring Insulin Resistance. Some complex. Some simple.