Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Circulation 52

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. Thus the effect of bempedoic acid on cardiovascular events in those with lower LDL cholesterol levels and those on therapeutic doses of statins were not evaluated.

Cholesterol 52

Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease. For many disease areas, nearly a half of drugs are approved by the U.S. Food & Drug Administration based on beneficial effects on surrogate endpoints.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Dr. Paddy Barrett

AUGUST 22, 2023

Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease. APO E is also centrally involved in cholesterol metabolism. Here’s how. What to do?

Cholesterol 52

Cholesterol Dementia Cardiovascular Disease Coronary Artery Disease 52

Journal of the American Heart Association

NOVEMBER 23, 2023

The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. Mice lackingFxrandGpbar1−/−/Fxr−/−display hypotension and aortic inflammation, along with altered intestinal permeability that deteriorates with age, and severe dysbiosis, along with dysregulated bile acid synthesis.

Aortic 40

Aortic Aneurysm Plaque Cholesterol 40

Stroke Journal

FEBRUARY 1, 2024

Albumin, B12, total bilirubin, cholesterol, CRP, ferritin, iron, folate, hbA1c, HDL, LDL, hemoglobin, MCV, INR, ALT, triglycerides, and vitamin D were abstracted from health records. Future biomarker studies are needed to better understand this relationship. This was not driven by ICH severity or explained by lab markers.

Hemorrhage 40

Hemorrhage BMI Outcomes Coronary Artery Disease 40

Stroke Journal

FEBRUARY 1, 2024

It is currently unknown if these associations are confounded by pleiotropic effects of the instrumental variables (IV) on cardiovascular disease (CVD) risk factors, such as low-density lipoprotein cholesterol (LDL), diastolic blood pressure (DBP), and body mass index (BMI).

BMI 40

BMI Risk Factors Stroke Strokes 40

Circulation: Cardiovascular Quality & Outcomes

OCTOBER 20, 2023

Current users (used within the past month) and never users were compared with assess the burden and control of traditional ASCVD risk factors and biomarkers, using inverse probability of treatment weighting to adjust for sociodemographic and lifestyle factors, including tobacco use.RESULTS:Of the 13 965 participants identified (mean age, 37.5;

Risk Factors 40

Risk Factors Cardiovascular Disease Cholesterol Biomarkers 40

DAIC

FEBRUARY 1, 2024

Elevated levels of two protein biomarkers that indicate heart damage were associated with undetected or symptomless cardiovascular disease in adults with Type 2 diabetes compared to those without Type 2 diabetes, according to new research published May 31, 2023, in the Journal of the American Heart Association, JAHA.

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Peripheral Arterial Disease Stroke 104

Physiologically Speaking

JANUARY 12, 2024

One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. A few biochemical measures were associated with biological age: higher triglycerides predicted faster age acceleration while higher HDL cholesterol predicted slower age acceleration.

Physiology 122

Physiology BMI Exercise Diet 122

DAIC

JANUARY 23, 2024

Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 21 Luckily, each of these risks can be measured by simple blood tests. N Engl J Med.

Cardiovascular Disease 111

Cardiovascular Disease Heart Attack Heart attacks Coronary Artery Disease 111

Open Heart

JUNE 29, 2023

Objective As thoracic aortic disease (TAD) is generally asymptomatic, biomarkers are needed to provide insight into early progression. We aimed to examine the association between circulating blood biomarkers and the maximal thoracic aortic diameter (TADmax). Results In total, 158 patients were included (median age 61 (50.3–68.8)

Biomarkers 52

Biomarkers Aortic Circulation Outpatient 52

Dr. Paddy Barrett

OCTOBER 31, 2023

They have the biomarker of risk but no evidence of the disease , even later in life when you would expect them to have it. A healthy lifestyle, in this instance, is defined by a combination of: BMI Nutrition Smoking Status Activity Levels Blood Pressure Diabetes Status Cholesterol Levels All of which are highly modifiable.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. 1 Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. This is the spark that sets the fire. Is a lot.

Heart Disease 87

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 87

Physiologically Speaking

AUGUST 9, 2024

For example, ketogenic diets raise LDL cholesterol, which some people believe is harmful. So rather than investigate how specific nutrients affect health biomarkers, there’s a growing interest in how restricting or supplying these nutrients might affect physical activity and energy expenditure, key factors in overall health.

Physiology 67

Physiology Diet Cholesterol Biomarkers 67

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Methods and results Mixed-effects meta-regression modeling of stand-alone MACE outcomes was performed, with therapy type, population demographics, baseline and change over time in lipid biomarkers as predictors. In total, 54 studies (270,471 patients) were collected, reporting 15 different single cardiovascular events.

Cholesterol 59

Cholesterol Biomarkers Outcomes 59

DAIC

JANUARY 30, 2024

The new model uses a set of 10 factors including age, cigarette smoking status, diabetes status, and blood levels of several cardiac biomarkers, to gauge the risk of a new cardiovascular event, regardless of whether the patient has had one before.

Cardiovascular Disease 52

Cardiovascular Disease Research Heart Attack Heart attacks 52

Journal of the American Heart Association

DECEMBER 29, 2023

1.38]) was also significantly associated with suspected MCI, after adjusting for age, sex, education level, mean arterial pressure, hypertension, diabetes, low‐density lipoprotein cholesterol, and smoking status. These findings suggest that Zc may be a useful biomarker for identifying individuals at risk for MCI.

Aortic 40

Aortic Education Cholesterol Biomarkers 40