Dr. Paddy Barrett

SEPTEMBER 13, 2024

Insulin resistance is a major risk factor for the leading causes of death, the leading one being cardiovascular disease. Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. Low HDL Cholesterol. But What Causes Insulin Resistance?

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Risk Factors Heart Disease Dementia Diabetes 105

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

For many disease areas, nearly a half of drugs are approved by the U.S. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease. Food & Drug Administration based on beneficial effects on surrogate endpoints.

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Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Heart BMJ

APRIL 15, 2024

This study sought to evaluate the prevalence of cardiovascular risk factors, overt cardiovascular disease and cardiac imaging abnormalities using cardiac magnetic resonance (CMR), in participants with normal LVEF on completion of trastuzumab±anthracycline therapy at least 5 years previously. years (range 5.9–10.8

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Cancer Risk Factors Biomarkers Cholesterol 52

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. CLEAR trial had patients for both primary and secondary prevention of cardiovascular disease. Median follow up was for 40.6 There was 29.2

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Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

Dr. Paddy Barrett

AUGUST 22, 2023

However Most people do not appreciate that being a carrier of APOE4 significantly increases the risk of cardiovascular disease also. APO E is also centrally involved in cholesterol metabolism. APO E is also centrally involved in cholesterol metabolism. i.e. LDL-Cholesterol/APOB goes down. Here’s how.

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Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

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Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Circulation: Cardiovascular Quality & Outcomes

OCTOBER 20, 2023

BACKGROUND:The relationship between marijuana use and cardiovascular health remains uncertain, with several observational studies suggesting a potential association with increased adverse atherosclerotic cardiovascular disease (ASCVD) outcomes. mg/dL,P=0.53), total cholesterol (191.2 female; 13% non-Hispanic Black), 26.6%

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Risk Factors Cardiovascular Disease Cholesterol Biomarkers 40

Journal of the American Heart Association

NOVEMBER 23, 2023

BackgroundPatients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. The expression of GPBAR1 in the human endothelium correlated with the expression of inflammatory biomarkers. Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023.

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Stroke Journal

FEBRUARY 1, 2024

It is currently unknown if these associations are confounded by pleiotropic effects of the instrumental variables (IV) on cardiovascular disease (CVD) risk factors, such as low-density lipoprotein cholesterol (LDL), diastolic blood pressure (DBP), and body mass index (BMI).

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Dr. Paddy Barrett

OCTOBER 31, 2023

In my experience, some patients present later in life with a significantly elevated Lp(a) but have no evidence of coronary artery disease. They have the biomarker of risk but no evidence of the disease , even later in life when you would expect them to have it. This is the case with an elevated Lp(a). Atherosclerosis.

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Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Dr. Malcolm Kendrick

OCTOBER 30, 2024

I, Dr Malcolm Kendrick, with or without other co-conspirators, would be accused of spreading misinformation about cholesterol and statins. The hypothesis that a raised cholesterol level causes heart disease [atherosclerotic cardiovascular disease (ASCVD)] is possibly the single most powerful idea in medicine.

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