Remove Biomarkers Remove Cardiac Function Remove Heart Failure
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Increased Plasma Pyruvate Kinase M2 (PK‐M2) in Heart Failure: A Novel Biomarker Related to Cardiac Function and its Clinical Implications

Journal of the American Heart Association

BackgroundThe purpose of this study was to investigate whether circulating pyruvate kinase M2 (PKM2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in patients with heart failure (HF).Methods Patients with HF had higher PKM2 levels than controls (17.44.1 versus 7.82.3

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Abstract 4139191: ETX-258 - A GalOmic™ siRNA for the Treatment of Heart Failure Following Myocardial Infarction

Circulation

Cardiac function was assessed by echocardiography at 2-, 4- and 6-weeks post-MI. Cardiac damage and structural remodeling were evaluated using circulating biomarkers of cardiac function and histological assessment.Results:ETX-258 was selected as a highly active siRNA for the treatment of heart failure with a long duration of action.

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Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism

Circulation

Macrophage-specific NPM1 deletion reduced infarct size, promoted angiogenesis, and suppressed tissue fibrosis, in turn improving cardiac function and protecting against adverse cardiac remodeling after MI. NPM1 may serve as a promising prognostic biomarker and a valuable therapeutic target for heart failure after MI.

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Myocardial sodium–glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO?AS study

European Journal of Heart Failure

Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT2) gene and protein in patients with severe AS stratified in high gradient (HG) and low flow-low gradient (LF-LG) AS and its association with cardiac functional impairments.

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New cardiovascular biomarkers in patients with advanced cancer – A prospective study comparing MR‐proADM, MR‐proANP, copeptin, high‐sensitivity troponin T and NT‐proBNP

European Journal of Heart Failure

( A ) Univariable receiver operating characteristic (ROC) curves for all biomarkers. ( Abstract Aims Traditional cardiovascular (CV) biomarkers (high-sensitivity troponinT [hsTnT] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) are important to monitor cancer patients' cardiac function and to assess prognosis.

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Echocardiographic assessment of the relationship between cardiac function and plasma homocysteine levels in patients with heart failure and preserved ejection fraction

Frontiers in Cardiovascular Medicine

A strong positive correlation was also observed between Hcy levels and New York Heart Association (NYHA) classification (r=0.824, p<0.001).ConclusionsThe ConclusionsThe findings indicate that elevated plasma homocysteine is associated with myocardial remodeling and impaired diastolic function in HFpEF patients.

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IGF-1 levels in the general population, heart failure patients, and individuals with acromegaly: differences and projections from meta-analyses—a dual perspective

Frontiers in Cardiovascular Medicine

BackgroundThe complex relationship between insulin-like growth factor 1 (IGF-1) levels and heart failure (HF) is not fully understood, particularly across different populations and conditions. Conversely, excessively high levels, as observed in acromegaly, are linked to a higher incidence of HF.