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BackgroundThe purpose of this study was to investigate whether circulating pyruvate kinase M2 (PKM2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in patients with heartfailure (HF).Methods Patients with HF had higher PKM2 levels than controls (17.44.1 versus 7.82.3
Cardiacfunction was assessed by echocardiography at 2-, 4- and 6-weeks post-MI. Cardiac damage and structural remodeling were evaluated using circulating biomarkers of cardiacfunction and histological assessment.Results:ETX-258 was selected as a highly active siRNA for the treatment of heartfailure with a long duration of action.
Macrophage-specific NPM1 deletion reduced infarct size, promoted angiogenesis, and suppressed tissue fibrosis, in turn improving cardiacfunction and protecting against adverse cardiac remodeling after MI. NPM1 may serve as a promising prognostic biomarker and a valuable therapeutic target for heartfailure after MI.
Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT2) gene and protein in patients with severe AS stratified in high gradient (HG) and low flow-low gradient (LF-LG) AS and its association with cardiacfunctional impairments.
( A ) Univariable receiver operating characteristic (ROC) curves for all biomarkers. ( Abstract Aims Traditional cardiovascular (CV) biomarkers (high-sensitivity troponinT [hsTnT] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]) are important to monitor cancer patients' cardiacfunction and to assess prognosis.
A strong positive correlation was also observed between Hcy levels and New York Heart Association (NYHA) classification (r=0.824, p<0.001).ConclusionsThe ConclusionsThe findings indicate that elevated plasma homocysteine is associated with myocardial remodeling and impaired diastolic function in HFpEF patients.
BackgroundThe complex relationship between insulin-like growth factor 1 (IGF-1) levels and heartfailure (HF) is not fully understood, particularly across different populations and conditions. Conversely, excessively high levels, as observed in acromegaly, are linked to a higher incidence of HF.
Detailed assessment of cardiacfunction after successful catheter ablation will reveal this. NT-proBNP levels were elevated in 18 (52.9%), and 16 reported ongoing heartfailure (HF) symptoms. 10 (29.4%) had no improvement in functional capacity, and seven (20.6%) showed persistent ventilatory inefficiency.
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