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Two common biomarkers can predict heart risk in asymptomatic childhood cancer survivors

Medical Xpress - Cardiology

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors. Jude lifetime cohort study (St.

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Increased Plasma Pyruvate Kinase M2 (PK‐M2) in Heart Failure: A Novel Biomarker Related to Cardiac Function and its Clinical Implications

Journal of the American Heart Association

U/mL,P<0.001), and these levels correlated with HF severity (New York Heart Association cardiac function class). These findings suggest that PKM2 is a potential biomarker for HF diagnosis and prognosis, warranting consideration for serial patient assessment. Patients with HF had higher PKM2 levels than controls (17.44.1

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Abstract 4139191: ETX-258 - A GalOmic™ siRNA for the Treatment of Heart Failure Following Myocardial Infarction

Circulation

Cardiac function was assessed by echocardiography at 2-, 4- and 6-weeks post-MI. Cardiac damage and structural remodeling were evaluated using circulating biomarkers of cardiac function and histological assessment.Results:ETX-258 was selected as a highly active siRNA for the treatment of heart failure with a long duration of action.

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Abstract 4134796: Safety of over 1000 consecutive, selected low risk patients with accelerated discharge from a chest pain unit with early generation cardiac troponin use, no cardiac functional or anatomic testing and no clinical risk scores

Circulation

These selected LR pts remained at reduced risk for cardiac events despite a high rate of comorbidities. Early discharge of selected LR CP pts based on history, examination, ECG, and biomarker evaluation was safe and effective.Conclusion:This approach in selected LR pts has the potential to reduce unnecessary diagnostic testing and CPU LOS.

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Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism

Circulation

Macrophage-specific NPM1 deletion reduced infarct size, promoted angiogenesis, and suppressed tissue fibrosis, in turn improving cardiac function and protecting against adverse cardiac remodeling after MI. NPM1 may serve as a promising prognostic biomarker and a valuable therapeutic target for heart failure after MI.

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Micro and Nanoplastics and Cardiovascular Events – Recent Study

All About Cardiovascular System and Disorders

Experimental studies have suggested that micro and nanoplastics promote oxidative stress, inflammation and apoptosis in endothelial and other vascular cells which could lead to impairement in cardiac function, myocardial fibrosis and endothelial dysfunction [4]. Inflammatory biomarkers were also estimated.

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Myocardial sodium–glucose cotransporter 2 expression and cardiac remodelling in patients with severe aortic stenosis: The BIO?AS study

European Journal of Heart Failure

Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT2) gene and protein in patients with severe AS stratified in high gradient (HG) and low flow-low gradient (LF-LG) AS and its association with cardiac functional impairments.