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Current consensus age- and BMI-stratified rule-in thresholds demonstrated only 65% specificity (95% CI, 57%72%). Current consensus age- and BMI-stratified rule-in thresholds demonstrated only 65% specificity (95% CI, 57%72%).
One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. Physical fitness was measured using VO2 peak obtained during a maximal exercise test (the gold standard way to measure this outcome).
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