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Physiology Friday #200: Higher Aerobic Fitness is Tied to Slower Biological Aging

Physiologically Speaking

One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. However, body mass index (BMI) was not associated with biological age acceleration. Smoking and consuming alcohol 5—7 times per week accelerated biological age.

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Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Stroke Journal

Body mass index (BMI) is a widely available marker of nutrition status, however studies on BMI and post-ICH outcomes are limited and have conflicting results. Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. 7.34) and lobar (OR 3.15, 95% CI 1.67-5.94)

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Abstract TP268: Xylitol, Xylose, and MicroRNAs Associated with Thrombosis and the Clotting Cascade in a Multi-Omics Cross-Sectional Study of Adults at Risk for Type 2 Diabetes and Stroke

Stroke Journal

MicroRNAs (miRs) have been associated with thrombosis and the blood clotting cascade and can provide additional insight about pathogenesis or biomarkers to help establish safe dietary intake guidelines. The mean BMI was 35.2 However, multiomics studies of both xylitol metabolites and these miRs in humans have not been done.

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Abstract 131: Association Between Left Ventricular Injury Detected by Cardiac MRI and Incident Ischemic Stroke: The Multi-Ethnic Study of Atherosclerosis

Stroke Journal

Participants with LVI were significantly older, male, Black, had higher BMI, and lower HDL. Participants with LVI were more likely to have diabetes, tobacco use, and atrial fibrillation (24% versus 14%, p<0.001). Further studies are needed to validate these CMR biomarkers of stroke risk.

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The Value Of Lifestyle In Those With An Elevated Lp(a)

Dr. Paddy Barrett

They have the biomarker of risk but no evidence of the disease , even later in life when you would expect them to have it. A healthy lifestyle, in this instance, is defined by a combination of: BMI Nutrition Smoking Status Activity Levels Blood Pressure Diabetes Status Cholesterol Levels All of which are highly modifiable.