article thumbnail

C-Reactive Protein Effective as Biomarker for HS Treated with Adalimumab

HCPLive

Patients in this post-hoc analysis with elevated CRP were found to have a higher BMI and more severe hidradenitis suppurativa.

article thumbnail

Unhealthy visceral fat is associated with improved efficacy of immunotherapy in endometrial cancer

Journal of Clinical Investigation - Cardiology

Notably, a BMI in the overweight or obese range was paradoxically associated with improved progression-free and overall survival. A second paradox emerged from CT analyses of visceral adipose tissue, viewed as an unhealthy fat depot in most other contexts, the quantity of which was also associated with improved treatment outcomes.

Cancer 63
article thumbnail

Evidence-Based Application of Natriuretic Peptides in the Evaluation of Chronic Heart Failure With Preserved Ejection Fraction in the Ambulatory Outpatient Setting

Circulation

Current consensus age- and BMI-stratified rule-in thresholds demonstrated only 65% specificity (95% CI, 57%72%). With a BMI 35 kg/m2, lower rule-in thresholds (220 pg/mL) provided good specificity (88% [95% CI, 73%100%]; 93% [95% CI, 81%100%] and 100% in validation cohorts).

article thumbnail

Risk factors and prediction model for new-onset hypertensive disorders of pregnancy: a retrospective cohort study

Frontiers in Cardiovascular Medicine

We collected maternal clinical parameters and biomarkers between 16th and 20th weeks of gestation. The HDP group exhibited significantly higher baseline body mass index (BMI), weight change, baseline systolic/diastolic blood pressure, and platelet counts than the control group. 1.17), 1.10 (1.05–1.16), 1.16), 1.04 (1.01–1.08),

article thumbnail

Physiology Friday #200: Higher Aerobic Fitness is Tied to Slower Biological Aging

Physiologically Speaking

One of the most promising biomarkers of biological age are so-called DNA methylation-based age estimators, otherwise known as DNA methylation age clocks. However, body mass index (BMI) was not associated with biological age acceleration. Smoking and consuming alcohol 5—7 times per week accelerated biological age.

article thumbnail

Metabolic dysfunction and incidence of heart failure subtypes among Black individuals: The Jackson Heart Study

European Journal of Heart Failure

We categorized participants based on MetS status and MetS severity scores (based on waist circumference [MetS-Z-WC] and body mass index [MetS-Z-BMI]). MetS severity was associated with subclinical cardiac remodelling (assessed by echocardiographic measures and biomarkers of myocardial damage).

article thumbnail

Abstract WMP81: Overweight Patients Had Higher Odds of Favorable Outcome After Both Deep and Lobar Intracerebral Hemorrhage

Stroke Journal

Body mass index (BMI) is a widely available marker of nutrition status, however studies on BMI and post-ICH outcomes are limited and have conflicting results. Patients were divided into underweight, normal weight, overweight, and obese according to World Health Organization BMI criteria. 7.34) and lobar (OR 3.15, 95% CI 1.67-5.94)