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Modulation of NOX2 causes obesity-mediated atrial fibrillation

Journal of Clinical Investigation - Cardiology

Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. Here, we studied NOX2-mediated ROS production in obesity-mediated AF using Nox2-knockout mice and mature human induced pluripotent stem cell–derived atrial cardiomyocytes (hiPSC-aCMs).

Obesity 97
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Dual vs Single Cardioversion of Atrial Fibrillation in Patients With Obesity

JAMA Cardiology

This randomized clinical trial investigates which strategy is more effective in patients with atrial fibrillation and obesity: dual or single direct-current cardioversion.

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PO-04-072 CATHETER ABLATION FOR ATRIAL FIBRILLATION IS SAFE IN HEART FAILURE PATIENTS WITH OBESITY

HeartRhythm

Catheter Ablation for Atrial Fibrillation (AFib) in heart failure is now a class I indication for patients with heart failure. Evidence supports the relationship between obesity and the incidence and recurrence of Afib.

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Dual vs. Single Cardioversion in Patients With Obesity

American College of Cardiology

The goal of the Dual vs. Single DCCV trial was to determine the efficacy and safety of dual direct-current cardioversion (DCCV) compared with single DCCV in patients with obesity and atrial fibrillation (AF) undergoing elective electrical cardioversion.

Obesity 56
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Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

Journal of the American Heart Association

ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited.

Obesity 45
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The causal relationship between obesity, obstructive sleep apnea and atrial fibrillation: a study based on mediated Mendelian randomization

Frontiers in Cardiovascular Medicine

BackgroundAtrial fibrillation (AF) is a common cardiac arrhythmia that is associated with obesity and obstructive sleep apnea syndrome (OSA). Through mediating MR analysis, it was found that OSA played a certain role in the causal relationship between obesity and AF, with about 6.4%

Obesity 52
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Challenges in the Cardiovascular Evaluation and Management of Patients With Obesity

American College of Cardiology

Obesity is a multifaceted disease that is directly and indirectly implicated in atherosclerotic cardiovascular disease (CVD), heart failure (HF), atrial fibrillation (AF), and multiple CVD risk factors, including dyslipidemia, hypertension, type 2 diabetes mellitus (DM), and sleep disorders.

Obesity 71