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atrialfibrillation (AF), a heart condition that causes an irregular heartbeat in the upper chambers of the heart, affects up to one in three people in their lifetime. Significant complications associated with this condition include ischemic stroke, heart failure, myocardial infarction, chronic kidneydisease, dementia and mortality.
Research objectiveThis study is based on bioinformatics analysis to explore the co-expressed differentially expressed genes (DEGs) between atrialfibrillation (AF) and chronic kidneydisease (CKD), identify the biomarkers for the occurrence and development of the two diseases, investigate the potential connections between AF and CKD, and explore the (..)
Limited evidence supports apixaban's use for atrialfibrillation (Af) in severe chronic kidneydisease (CKD) or end-stage kidneydisease (ESKD) patients, where warfarin is often contraindicated.
Atrialfibrillation (AF) is a relatively prevalent arrhythmia in patients with kidney failure requiring dialysis, who face a high risk of stroke and bleeding, and anticoagulation is a challenging decision.
The term ‘epidemic’ is increasingly used to describe the rising global prevalence of atrialfibrillation (AF). The association between AF and various conditions—including hypertension, heart failure, sleep apnoea and chronic kidneydisease—is well-described, highlighting that AF is often a multisystem disorder.
Background:The prevalence of renal disease is increasing in the U.S. Renal dysfunction increases risk of atrialfibrillation, ischemic stroke and systemic bleeding. For the analysis, subjects were categorized as advanced chronic kidneydisease (CKD, CrCl 15-30) and end stage renal disease (ESRD, CrCl<15).Results:Of
Background There is a paucity of data on the initiation patterns of anticoagulants among older atrialfibrillation patients with and without chronic kidneydisease (CKD).
BackgroundThis realworld evidence study compared risks of cardiovascular events in hospital settings among patients with chronic kidneydisease (CKD) with and without hyperkalemia.Methods and ResultsAdults with CKD stages 3b/4 with and without hyperkalemia were identified from Optum's deidentified Market Clarity Data (January 2016August 2022).
Patients with atrialfibrillation (AF) taking antithrombotic (AT) therapy are at increased risk of gastrointestinal bleeding (GIB). Patients with atrialfibrillation (AF) taking antithrombotic (AT) therapy are at increased risk of gastrointestinal bleeding (GIB).
ABSTRACT Introduction Pulmonary vein isolation (PVI) by cryoballoon ablation (CBA) is considered an effective primary strategy for early persistent atrialfibrillation (AF). However, data regarding CBA for long-standing persistent AF (PeAF) are limited. years, 80% men) underwent de novo CBA. During a mean follow-up period of 15.110.9
Abstract Introduction Influence of early atrialfibrillation (AF) ablation, particularly cryoballoon ablation (CBA), on clinical outcome during long-term follow-up has not been clarified. The primary outcome was recurrence of atrial tachyarrhythmias (ATs) of ≥30-s after a 3-month blanking period. vs. 31.7%, p = 0.043).
Getty Images milla1cf Fri, 12/08/2023 - 08:17 December 8, 2023 — The American College of Cardiology (ACC) and the American Heart Association (AHA), along with several other leading medical associations, have issued a new guideline for preventing and optimally managing atrialfibrillation (AFib).
Introduction:Intracranial hemorrhage (ICH) is the most severe adverse effect of anticoagulation in atrialfibrillation (AF) patients. Hypertension, diabetes, hyperlipidemia, and chronic kidneydisease are well-known cardiovascular risk factors for ICH. Stroke, Volume 56, Issue Suppl_1 , Page A49-A49, February 1, 2025.
Left atrial appendage closure (LAAC) is an alternative to reduce thrombotic risk in patients with non-valvular atrialfibrillation. A significant proportion of patients who underwent this procedure have chronic kidneydisease, presenting a high risk of contrast-induced nephropathy.
Six multimorbidity patterns were identified, including 4 specific patterns: (1) pattern 1, cerebrovascular cluster (histories of cerebrovascular disease and hypertension); (2) pattern 2, traditional cardiovascular disease risk factors cluster (histories of hyperlipidemia, obesity, anddiabetes, and family history of cardiovascular disease and smoking); (..)
Survival was higher among the younger patients, and among those with hypertension or atrialfibrillation (AF). Mortality was increased with male gender, valvular heart disease and chronic kidneydisease. to 0.97; p=0.02).
Propensity score-matched analysis (PSM) (1:1) was performed with matching for age, gender, race, BMI, hypertension, diabetes mellitus, chronic kidneydisease, hemoglobin level, low-density lipid (LDL) level, left ventricular ejection fraction, and various drugs including ACEi, ARBi, ARNI, beta-blockers, and diuretics.
17.4]) and was also more likely to have diabetes mellitus, hyperlipidemia, chronic lung disease, chronic kidneydisease, chronic liver disease, BMI ≥ 25, anemia, metastatic cancer, and atrialfibrillation. The hemophilia cohort was slightly older (63.2[16.8]
The prevalence of HF risk factors was high: hypertension, 61.9%; former or current smoking, 53.7%; obesity 34.8%; diabetes; 24.7%; and chronic kidneydisease; 22%. Overt cardiovascular disease, which ranged from 2.1% (HF) to 13.6% (atrialfibrillation), was less common.
vs. 54.7%, SD 0.6), and had a lower burden of atrialfibrillation (4.5% vs. 6.9%, SD 0.1), chronic kidneydisease (1.9% Patients with migraine were younger (40.2±15.2 standardized difference (SD) 0.38), more likely to be female (81.4% vs. 3.6%, SD 0.2), and congestive cardiac failure (2.7% vs. 5.1%, SD 0.12).
vs 63.38, p<0.001) and had fewer comorbidities such as cancer and chronic kidneydisease, atrialfibrillation, hypertension, hyperlipidemia. We observed an increasing trend of ICH among pregnant individuals. Pregnant patients were notably younger (30.63 vs 16.2%, p<0.001). vs 23.2%, p<0.001).
Logistic regression was used to analyze the relationship between the treatment groups and hospital readmission within 90 days.Results:Only 517 AA met inclusion criteria and did not meet exclusion criteria, which included a history of valvular heart disease, hypertrophic or restrictive cardiomyopathy, active myocarditis, history of cardiac arrest, and (..)
had chronic kidneydisease, and 60.6% had atrialfibrillation. We performed the least absolute shrinkage and selection operator logistic regression to predict escalation.Results:We included 437 hospitalizations; patients had a median age of 80 (interquartile range, 69–89) years, 58.1% were women, and 64.8% were White.
In addition to direct hepatic complications, extra-hepatic complications, including cardiovascular diseases (CVD), type 2 diabetes (T2D), gastroesophageal reflux disease, chronic kidneydisease and some malignancies, are increasingly recognized.
25 include Efficacy and safety of finerenone across the spectrum of kidney risk in heart failure with mildly reduced or preserved ejection fraction during the session;"Innovations and Insights in Heart Failure With Preserved Ejection Fraction: Emerging Therapies, Biomarkers and Mechanistic Studies." Additional ACC.25
Background Chronic kidneydisease (CKD) and atrialfibrillation (AF) are increasing in prevalence globally and share common risk factors. Our aim was to characterise real-world evidence on direct oral anticoagulant (DOAC) prescribing for people with AF and CKD, in terms of adherence, persistence and renal dose titration.
million Americans have atrialfibrillation. Atrialfibrillation, a rapid, irregular heart beat that can lead to stroke or sudden death, is three times more common than previously thought, affecting nearly 5 percent of the population, or 10.5 tim.hodson Wed, 09/11/2024 - 15:40 Sept. million U.S. million U.S.
Rate vs Rhythm Control in AtrialFibrillation Rate vs rhythm control as a management strategy in atrialfibrillation has been a long standing topic for debate. EAST-AFNET 4 trial had 2789 patients with early atrialfibrillation and cardiovascular conditions [8]. years of follow up per patient.
Aims To describe the use of warfarin and direct oral anticoagulants (DOACs) in patients with atrialfibrillation (AF) and chronic kidneydisease (CKD), to evaluate changes in renal function over time and predictors of rapid decline, and to describe time in therapeutic range (TTR) and predictors of poor TTR among patients on warfarin.
Objectives Accurate prediction of heart failure (HF) patients at high risk of atrialfibrillation (AF) represents a potentially valuable tool to inform shared decision making. No validated prediction model for AF in HF is currently available. The objective was to develop clinical prediction models for 1-year risk of AF.
million Americans have atrialfibrillation. Atrialfibrillation, a rapid, irregular heart beat that can lead to stroke or sudden death, is three times more common than previously thought, affecting nearly 5 percent of the population, or 10.5 tim.hodson Wed, 09/11/2024 - 15:40 Sept. million U.S. million U.S.
BACKGROUND:Limited data exist on the temporal relationship between new-onset atrialfibrillation (AF) and ischemic stroke and its impact on patients’ clinical characteristics and mortality.METHODS:A population-based registry-linkage database includes all patients with new-onset AF in Finland from 2007 to 2018. Stroke, Ahead of Print.
Left untreated, tricuspid regurgitation can lead to atrialfibrillation , heart failure , kidneydisease and even death. Current nonsurgical treatments include diuretics (medicines that help remove excess fluid and salt) and drugs aimed at easing symptoms. Rogers , professor of cardiovascular medicine.
had no CKM syndrome risk factors, while 26% were at Stage 1 (overweight, prediabetes), 49% were Stage 2 (hypertension, diabetes, CKD), 5% had Stage 3 (kidneydisease or high CVD risks), and 9% were Stage 4 (heart disease, with or without kidneydisease). A JAMA analysis of 11k adults revealed that only 10.6%
Objective Risk-guided atrialfibrillation (AF) screening may be an opportunity to prevent adverse events in addition to stroke. We compared events rates for new diagnoses of cardio-renal-metabolic diseases and death in individuals identified at higher versus lower-predicted AF risk. to 6.98; 4.28), valvular heart disease (37.8;
25 include Efficacy and safety of finerenone across the spectrum of kidney risk in heart failure with mildly reduced or preserved ejection fraction during the session;"Innovations and Insights in Heart Failure With Preserved Ejection Fraction: Emerging Therapies, Biomarkers and Mechanistic Studies." Additional ACC.25
Measuring eGFR and albuminuria is recommended for assessing kidneydisease in all hypertensive patients. Below are some of the most notable highlights: 2024 ESC Updated Clinical Guidelines: Key updates include clopidogrel as a first-line option for long-term use after MI or PCI.
In multivariate regression analysis, the factors independently associated with a greater risk of readmission within 90 days were hypercoagulation (1.359 [95%CI, 1.1274‐1.45]), opiod abuse and dependence (1.353 [95%CI, 1.238‐1.478]), chronic kidneydisease (1.347 [95%CI, 1.316‐1.379]), liver disease (1.318 [95% CI, 1.26‐1.378]),
Results Higher baseline PICP, PRO-C6 and PINP levels were associated with older age, a more severe HF presentation, higher levels of natriuretic peptides and high-sensitivity troponin T, and the presence of comorbid conditions such as chronic kidneydisease and atrialfibrillation.
Predictors of high-risk of advanced liver fibrosis, included older age, male sex, severe chronic kidneydisease, previous myocardial infarction, ischemic heart disease, and atrialfibrillation/flutter. High-risk of advanced liver fibrosis was highly prevalent, affecting 30% of the studied population.
Characteristics associated with intracranial stent utilization were male sex, history of diabetes, hypertension, or chronic kidneydisease, absence of atrialfibrillation or CHF, and southern US region. women; mean age, 69.1 [SD, years; mean NIHSS score of 15.1 [SD, years; mean NIHSS score of 13.8 [SD,
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