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Researchers develop nanoparticle technology for targeted diagnosis and treatment of atherosclerosis

Science Daily - Heart Disease

A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner.

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Robust Diagnostic Accuracy and Prognostic Utility in Analyses from Large Scale Clinical Trials

DAIC

The study describes the validation of Cleerly's artificial intelligence-guided quantitative coronary CT angiography (AI-QCT) ISCHEMIA technology for diagnostic accuracy and prognostic risk stratification. Earls, MD , Chief Medical Officer of Cleerly.

Ischemia 110
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The Role of Genetics in Heart Disease: Can You Prevent It?

MIBHS

Inflammation: Genetic variations can make some people more prone to chronic inflammation, which contributes to the development of atherosclerosis. Gene-based therapies and interventions, such as gene editing technologies, show potential in treating hereditary conditions, although these treatments are still in early stages.

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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis

Circulation

However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown. We explored the mechanism of METTL4 involvement in atherosclerosis usingMettl4Mac-KO-Apoe-/-andMettl4MUT-Apoe-/-mice and cell models, as well as bone marrow transplantation.

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Novel UV?B Phototherapy With a Light?Emitting Diode Device Prevents Atherosclerosis by Augmenting Regulatory T?Cell Responses in Mice

Journal of the American Heart Association

BackgroundUltraviolet B (UV‐B) irradiation is an effective treatment for human cutaneous disorders and was shown to reduce experimental atherosclerosis by attenuating immunoinflammatory responses. Our findings indicate that a novel 282 nm UV‐B phototherapy could be an attractive approach to treat atherosclerosis.

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How to Use Imaging: Complex Cases of Atherosclerosis, Myocardial Inflammation, and Cardiomyopathy in Cardio-Oncology

Circulation: Cardiovascular Imaging

This can manifest as a multitude of pathologies including left ventricular dysfunction, myocarditis, cardiomyopathy, accelerated atherosclerosis, and coronary vasospasm. As the field of cardio-oncology continues to expand rapidly, guidance on the management of such toxicities and the development of imaging technologies is crucial.

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Cleerly Receives FDA Breakthrough Device Designation for Heart Disease Risk Staging System

DAIC

The CAD Staging System is a noninvasive imaging-based investigational software device that analyzes important and actionable features of coronary atherosclerosis, stenosis and ischemia. Cleerly is committed to accelerating the availability of its technology to healthcare providers and patients alike.