Science Daily - Heart Disease

NOVEMBER 13, 2024

Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

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Cardiovascular Disease Heart Attack Heart attacks Plaque 113

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP56-AWP56, February 1, 2025. Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). CSVD was assessed using the log of WMH volume.

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Atherosclerosis Stenosis Education Risk Factors 75

Circulation

JANUARY 24, 2024

METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.

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Heart Disease Stroke Strokes Peripheral Arterial Disease 81

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

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Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 60

Science Daily - Heart Disease

FEBRUARY 19, 2024

Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The researchers also showed in preclinical studies that 4PY directly triggers vascular inflammation which damages blood vessels and can lead to atherosclerosis over time.

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Heart Disease Heart Attack Heart attacks Atherosclerosis 123

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A41-A41, February 1, 2025. This is largely due to the Stenting and Aggressive Medical Management Therapy for Preventing Recurrent Stroke in Intracranial Arterial Stenosis (SAMMPRIS) trial results which featured a high periprocedural stroke rate.

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Journal of the American Heart Association

APRIL 3, 2025

BackgroundIschemic stroke incidence in young adults is increasing globally, with return to work (RTW) a key rehabilitation goal. In this multicenter cohort, 68.8% (249/362) of young patients with ischemic stroke returned to work, while 87.8% (318/362) achieved functional recovery.

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Stroke Strokes Atherosclerosis Diabetes 45

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP292-AWP292, February 1, 2025. Background:Intracranial atherosclerosis (ICAS) is a common stroke cause, with a recurrent stroke risk of up to 18% per year despite treatment advances. The primary outcome was the incidence of stroke. The weighted mean age was 63.7

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP116-AWP116, February 1, 2024. Both lumen stenosis and plaque components were correlated with multiple or recurrent infarcts in this population.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP260-AWP260, February 1, 2025. Background:The mechanisms by which intracranial atherosclerosis (ICAS) contributes to large-vessel occlusion strokes (LVOS) remains unclear.

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Stroke Journal

OCTOBER 18, 2023

Stroke, Volume 54, Issue 12 , Page 3165-3168, December 1, 2023. BACKGROUND:RICAMIS trial (The Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke) has demonstrated efficacy of remote ischemic conditioning (RIC) in acute ischemic stroke. to 9.3%];P=0.12).

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Atherosclerosis Stroke Strokes Outcomes 40

Journal of the American Heart Association

FEBRUARY 8, 2025

BackgroundAtrial fibrillation (AF) significantly increases the ischemic stroke risk. Cox regression models and competing risk survival analyses were used to assess incidence rates and hazard ratios (HRs) for ischemic stroke stratified by age groups. Among 47 239 participants (median followup: 21.1 The presence of AF yielded a 13.9

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Atrial Fibrillation Stroke Strokes Atherosclerosis 45

Frontiers in Cardiovascular Medicine

DECEMBER 5, 2024

The fundamental role of qualitative alterations of lipoproteins in the early development of atherosclerosis has been widely demonstrated. However, the corresponding studies are scarcer in the field of ischemic stroke, despite carotid arteriosclerosis progression underlies at least 20% of ischemic strokes.

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Circulation Stroke Strokes Atherosclerosis 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP142-ATP142, February 1, 2024. Introduction:Perfusion imaging has been used to assess collateral status in patients with acute ischemic stroke secondary to anterior large-vessel occlusion. A relative CBF<30% was also obtained.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP300-ATP300, February 1, 2024. Background:Most ischemic strokes are caused by atherosclerosis. Apolipoprotein E (ApoE) regulates lipid metabolism, and its deficiency is associated with dyslipidemia and atherosclerosis. Poor dietary habits promote the onset of atherosclerosis.

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Atherosclerosis Risk Factors Diet Plaque 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP73-AWMP73, February 1, 2025. Background:During the course of an ischemic stroke hospitalization, the initial diagnosis of the causative mechanism or etiology of stroke may evolve.

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American College of Cardiology

JANUARY 10, 2024

The goal of the INSPIRES trial was to determine whether DAPT with clopidogrel and aspirin initiated within 72 hours of mild ischemic stroke or high-risk TIA was associated with decreased incidence of recurrent stroke compared with aspirin monotherapy.

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Atherosclerosis Stroke Strokes Article 65

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A131-A131, February 1, 2024. The primary outcome was incident ischemic stroke. There were a total of 18 ischemic stroke events among those with LVI (6%) and 65 among those without LVI (3%). LV apical circumferential strain>-10% may be a novel and quantitative stroke risk factor.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP245-ATP245, February 1, 2024. Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. Accurate identification of stroke etiology is vital for secondary stroke prevention. p<0.01).Conclusions:Our

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A72-A72, February 1, 2024. Introduction:Associations between stroke subtype and post-stroke cognitive decline are unclear. Of the ischemic strokes, 22% were small-vessel occlusion, 8% large artery atherosclerosis, 21% cardioembolic, and 49% cryptogenic/other determined etiology.

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Stroke Strokes Hemorrhage Atherosclerosis 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023. The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease.

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Stroke Strokes Atherosclerosis Coronary Artery Disease 40

CTVS

OCTOBER 30, 2024

Common examples of vascular disease are aneurysms (a dangerous bulge in an artery wall), atherosclerosis (plaque buildup in the… Source Vascular disease affects the body’s vast network of blood vessels, veins and arteries.

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Aneurysm Plaque Atherosclerosis Heart Disease 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP222-ATP222, February 1, 2025. Background:Symptomatic intracranial atherosclerotic disease carries a high stroke recurrence rate. Accurate prediction of stroke recurrence is critical for improving patient outcomes through timely and targeted interventions. Variables with p<0.05

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Stroke Strokes Atherosclerosis Stenosis 40

Stroke: Vascular and Interventional Neurology

SEPTEMBER 3, 2024

Stroke: Vascular and Interventional Neurology, Volume 4, Issue 6 , November 1, 2024. BackgroundPrior studies have suggested an association between clot histological composition and cause of stroke. A total of 1656 patients had continuous data on clot composition and its association with cause of stroke.

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Stroke Strokes Atherosclerosis Article 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP268-AWP268, February 1, 2025. Introduction:The overall composition of stroke subtype is typically stable within biogeographical groups. Whether the COVID-19 pandemic impacted stroke etiology is still being investigated, but most studies have been performed outside the United States.

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP311-ATP311, February 1, 2025. Introduction:Immune Checkpoint Inhibitors (ICIs) used for treatment of malignancies might promote atherosclerosis and increase the risk of ischemic stroke (IS). We collected demographics and stroke characteristics. range 27-386) vs. ICI 337.5

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP332-ATP332, February 1, 2025. Introduction:Subclinical hyperthyroidism has been linked to an increased risk of atrial fibrillation, which elevates the likelihood of cardioembolism, cryptogenic stroke (CS), and embolic stroke of undetermined source (ESUS). 4.2uIU/mL).

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATMP73-ATMP73, February 1, 2025. Background:The therapeutic time window of endovascular therapy (EVT) for acute ischemic stroke (AIS) has been expanded up to 24 hours of onset. Patients were divided into 3 groups according to time from onset to hospital arrival (early: <4.5

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Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCocaine‐induced vasospasm of small vessels has long been proposed as a mechanism for ischemic stroke (1). ResultsA total of 74 patients were identified to have a positive cocaine status on admission with a diagnosis of new strokes.

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Stroke Strokes Atherosclerosis Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP82-ATP82, February 1, 2024. Introduction:The incidence of Large Vessel Occlusion-Acute Ischemic Stroke (LVO-AIS) continues to increase in young adults. 31 patients (18%) had stroke etiology as Large Artery Atherosclerosis (per TOAST criteria). went home, 12.9% SNF, and 6.5%

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Stroke Strokes Atherosclerosis Thrombolysis 40

Journal of the American Heart Association

DECEMBER 19, 2024

BackgroundElevated lowdensity lipoprotein cholesterol is a risk factor for atherosclerotic cardiovascular disease, including acute ischemic stroke (AIS), due to large and smallvessel disease. Lack of prestroke LLT use was associated with more severe stroke symptoms upon presentation.

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HeartRhythm

APRIL 30, 2024

Lower (worse) left atrial (LA) function—a hallmark of atrial myopathy—is linked to higher risk of ischemic stroke independent of atrial fibrillation (AF).

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Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2024

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP261-ATP261, February 1, 2024. Introduction:There are several pathogenic mechanisms that have been theorized for cocaine-related ischemic strokes (CRIS). The most common category under the TOAST criteria was large artery atherosclerosis (39.2%). Among the cocaine-positive cohort, 10.8%

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Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP326-ATP326, February 1, 2025. This finding may suggest that AF detected on an insertable cardiac monitor in cryptogenic stroke is often not pathogenic. The primary predictor was stroke subtype (ESUS vs. non-cardioembolic). ESUS was defined using the ESUS consensus criteria.

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Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP241-AWP241, February 1, 2024. Background:Migraine with aura is a risk factor for ischemic stroke. We refined the migraine with aura risk score (MARS) to create the migraine associated risk of stroke score (MARS Plus) making it applicable to migraine with and without aura.

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Stroke Strokes Risk Factors Coronary Artery Disease 40

Journal of the American Heart Association

FEBRUARY 14, 2024

BackgroundPatent foramen ovale (PFO) is causally associated with stroke in some patients younger than 60 years, especially when it is large or associated with an atrial septal aneurysm (ASA). Among 533 patients (median National Institutes of Health Stroke Scale score=1), PFO was present in 152 (prevalence, 28.5% [95% CI, 24.9–32.5]).

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