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Researchers show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.
MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE. When they break loose, they can be deadly, triggering strokes and heart attacks.
University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.
In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions for causing a stroke or heart attack.
Researchers at Case Western Reserve University have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.
Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.
The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 mg on atherosclerotic plaque. Budoff, M.D.,
People with type 2 diabetes have a higher risk of suffering a stroke, a heart attack and premature death due to atherosclerosis, but it has been unclear what the underlying mechanisms are.
Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosisplaque is unknown. However, such studies are rare and limited to animal experiments.
Common examples of vascular disease are aneurysms (a dangerous bulge in an artery wall), atherosclerosis (plaque buildup in the… Source Vascular disease affects the body’s vast network of blood vessels, veins and arteries.
Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.
Stroke, Volume 55, Issue Suppl_1 , Page AWP116-AWP116, February 1, 2024. Ipsilateral and contralateral carotid artery plaque features were compared, then the carotid artery plaque characteristics on the infarct side were correlated with the infarct pattern.Results:the mean age of subjects included was 68 years old, 79.6%
This registry will aim to provide world-wide physicians the most accurate information on coronary plaque to improve cardiovascular risk prediction and support the selection of patient-specific treatment,” said Dr. De Cecco. The ultimate goal is to positively impact cardiovascular health globally with a reduction in cardiovascular events."
The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients.
15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. tim.hodson Tue, 10/15/2024 - 12:12 Oct.
Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.
Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.
Stroke, Volume 55, Issue Suppl_1 , Page ATP300-ATP300, February 1, 2024. Background:Most ischemic strokes are caused by atherosclerosis. Atherosclerotic plaque formation is modulated by genetic and environmental interactions. Poor dietary habits promote the onset of atherosclerosis.
Artery Damage : Hypertension damages the inner lining of your arteries, making them less elastic and more prone to plaque buildup. This condition, called atherosclerosis, narrows the arteries, restricting blood flow and increasing the risk of heart attacks and strokes.
The pathology that causes heart disease (atherosclerosis) is, by definition, the abnormal retention of a cholesterol particle in the artery wall. A heart attack is when that plaque ruptures and stops blood flow down the artery. 1 ” Good question. Cholesterol is an essential part of that process.
Stroke, Volume 56, Issue Suppl_1 , Page ATP288-ATP288, February 1, 2025. Carotid atherosclerosis (CAS) is a critical precursor to atherosclerotic cardiovascular disease and is closely associated with the development and progression of conditions such as stroke and poor prognosis. 2021-KY-1289-001).Results:Among respectively.
Stroke, Volume 56, Issue Suppl_1 , Page A110-A110, February 1, 2025. Background:Recent studies have shown that the autonomic nervous system plays a crucial role in regulating the initiation and progression of atherosclerosis in peripheral arteries.
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4
Stroke, Volume 55, Issue Suppl_1 , Page ATP226-ATP226, February 1, 2024. Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. Carotid ultrasound results were divided into two groups based on the presence or absence of plaque. 1692 (64.6%) were male.
About a fifth of all ischemic strokes are attributed to embolization of ruptured atherosclerotic plaque from carotid arterial stenosis. But it has been difficult to predict which person with asymptomatic carotid artery stenosis is likely to progress to symptomatic carotid disease and stroke.
Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023. The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease.
The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 mg on atherosclerotic plaque. Budoff, M.D.,
“By adding AutoChamber AI to thoracic CT scans including coronary artery calcium (CAC) and coronary CT angiography (CCTA), doctors not only can evaluate coronary disease but also the risk of heart failure, atrial fibrillation and stroke which are not reported today.
Stroke, Volume 55, Issue Suppl_1 , Page ATMP72-ATMP72, February 1, 2024. Background:Intracranial Atherosclerosis (ICAS) leads to stroke by perforator disease, artery to artery embolism, and impaired distal flow/perfusion. Patients were treated with medical treatment and followed for 30-days post stroke.
Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries. Arrhythmias: Genetic mutations can also predispose individuals to irregular heart rhythms, such as atrial fibrillation or long QT syndrome, which may increase the risk of stroke or sudden cardiac arrest.
Stroke-volume:50 ml. MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. Left ventricular end-diastolic volume: 99 ml.
A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. A CT CAC scan of 0 indicates no significant amount of calcified atherosclerosis.
Stroke, Volume 56, Issue Suppl_1 , Page ATMP54-ATMP54, February 1, 2025. Background:Rapid, accurate diagnosis and characterization of carotid atherosclerosis can help prevent disabling strokes. Although carotid plaques can be identified on CT angiography (CTA), interpretation is challenging for frontline physicians.
A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).
Stroke, Ahead of Print. Asymptomatic high-grade carotid stenosis is an important therapeutic target for stroke prevention. Advances in treatments against atherosclerosis have driven down the rates of stroke in patients managed without revascularization.
While this response is adaptive in the short term, chronic stress keeps your blood pressure elevated for extended periods, increasing your risk of hypertension (high blood pressure) and its associated complications, such as heart disease and stroke.
This refers to all the steps necessary to reduce the odds of a subsequent event, such as a second heart attack or stroke. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. But there is another type of prevention. Secondary prevention.
Stroke, Volume 56, Issue Suppl_1 , Page ATP258-ATP258, February 1, 2025. Introduction:Mechanical thrombectomy (MT) devices were fundamentally designed for the treatment of cardioembolic (CE) strokes despite that 10-20% of large vessel occlusions (LVO) are caused by large artery atherosclerosis (LAA), which may not respond comparably.
(Naturopathic Medicine) According to a subanalysis of a randomised study, low-dose edoxaban (Savaysa) was related with a reduced stroke risk and a negligible increase in bleeding in older Afib patients at high bleeding risk.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. There is subsequent hypoperfusion of brain tissue, but thromboembolism and ischemic stroke is rare. There is subsequent hypoperfusion of brain tissue, but thromboembolism and ischemic stroke is rare.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEndovascular intervention has become the mainstay of treatment for acute ischemic stroke. Both patients in our study survived at 6‐month follow up with no recurrence of stroke.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionAtherosclerosis, the hardening and narrowing of the arteries, occurs due to the buildup of plaque on the inner walls of the arteries which can result in reduced blood flow to the organs and tissues.
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionOcular ischemic syndrome (OIS) is a rare, vision‐threatening condition resulting from severe carotid artery disease secondary to severe atherosclerosis or arteritis. Carotid artery atherosclerosis is the most common etiology.
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