Medical Xpress - Cardiology

NOVEMBER 20, 2024

In a new study published in the European Heart Journal, researchers at Karolinska Institutet show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions for causing a stroke or heart attack.

Heart Attack 84

Heart Attack Heart attacks Plaque Stroke 84

Science Daily - Heart Disease

NOVEMBER 20, 2024

Researchers show that genetic traits influence the cellular composition of atherosclerotic plaques, which over time will affect the risk of such lesions to cause a stroke or heart attack. The new knowledge can be used to improve the risk assessment and treatment of patients with atherosclerosis in the future.

Heart Attack 81

Heart Attack Heart attacks Plaque Stroke 81

Nature Reviews - Cardiology

JANUARY 1, 2024

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00957-0 Macrophages in atherosclerotic plaques can undergo apoptosis and several forms of regulated necrosis, including necroptosis, pyroptosis and ferroptosis.

Atherosclerosis 86

Atherosclerosis Plaque 86

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Notably, Apoe–/– mice expressing LL37 developed larger atheroma plaques than did control mice, and a positive correlation between plasma LL37 and oxidized phospholipid on apolipoprotein B (OxPL-apoB) levels was observed in individuals with cardiovascular disease.

Atherosclerosis 122

Atherosclerosis Cholesterol Cardiovascular Disease Plaque 122

Medical Xpress - Cardiology

DECEMBER 9, 2024

People with type 2 diabetes have a higher risk of suffering a stroke, a heart attack and premature death due to atherosclerosis, but it has been unclear what the underlying mechanisms are.

Diabetes 89

Diabetes Plaque Heart Attack Heart attacks 89

Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2024

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. However, such studies are rare and limited to animal experiments.

Plaque 64

Plaque Diabetes Atherosclerosis Stroke 64

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Frontiers in Cardiovascular Medicine

APRIL 4, 2024

Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis.

Atherosclerosis 52

Atherosclerosis Plaque 52

Physiologically Speaking

DECEMBER 17, 2024

Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease. Cross-sectional studies reveal that endurance athletes, particularly middle-aged and older men, often exhibit higher coronary artery calcium scores (CACS) and plaque prevalence compared to less-active individuals.

Risk Factors 105

Risk Factors Genetic predisposition Plaque Exercise 105

Frontiers in Cardiovascular Medicine

JULY 24, 2024

Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed.

Atherosclerosis 52

Atherosclerosis Plaque Coronary Artery Disease Risk Factors 52

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

Science Daily - Heart Disease

SEPTEMBER 18, 2024

The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

Cardiovascular Disease 99

Cardiovascular Disease Atherosclerosis Plaque Risk Factors 99

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

Atherosclerosis 58

Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 58

Frontiers in Cardiovascular Medicine

DECEMBER 15, 2024

Coronary artery disease (CAD)cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteriesis responsible for disabilities of millions of people worldwide and remains the most common single cause of death. Human studies in this area are limited by small sample size and often nonrandomized character.

Coronary Artery Disease 93

Coronary Artery Disease Atherosclerosis Plaque 93

Stroke Journal

FEBRUARY 1, 2024

Ipsilateral and contralateral carotid artery plaque features were compared, then the carotid artery plaque characteristics on the infarct side were correlated with the infarct pattern.Results:the mean age of subjects included was 68 years old, 79.6% of them were male. 0.15), larger wall area (0.50±0.19 0.23), all p values<0.05.

Plaque 40

Plaque Atherosclerosis Stroke Strokes 40

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

Atherosclerosis 59

Atherosclerosis Plaque Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

NOVEMBER 25, 2024

In this investigation, our objective is to establish computational models elucidating molecular-level markers associated with atherosclerosis. Nevertheless, our current understanding of its pathogenesis remains imprecise. Utilizing single-cell sequencing, highly variable atherosclerotic monocyte subpopulations were systematically identified.

Atherosclerosis 59

Atherosclerosis Biomarkers Plaque Hypertension 59

Science Daily - Heart Disease

NOVEMBER 13, 2024

Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

Cardiovascular Disease 85

Cardiovascular Disease Heart Attack Heart attacks Atherosclerosis 85

Frontiers in Cardiovascular Medicine

FEBRUARY 8, 2024

Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.

Plaque 59

Plaque Angina Myocardial Infarction Risk Factors 59

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

Risk Factors 108

Risk Factors Heart Disease Heart Attack Heart attacks 108

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients.

Plaque 52

Plaque Biomarkers Circulation Stenosis 52

HCPLive

APRIL 24, 2024

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

Atherosclerosis 64

Atherosclerosis Plaque 64

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Korean Circ J.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

Dr. Smith's ECG Blog

SEPTEMBER 18, 2024

Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by 40% of the arterial cross section may be involved by plaque. The pathologist may see a plaque that constitutes, for example, 50% of the cross-sectional area.

Ischemia 116

Ischemia Plaque Stenosis Myocardial Infarction 116

DAIC

JULY 18, 2024

This registry will aim to provide world-wide physicians the most accurate information on coronary plaque to improve cardiovascular risk prediction and support the selection of patient-specific treatment,” said Dr. De Cecco. The ultimate goal is to positively impact cardiovascular health globally with a reduction in cardiovascular events."

Plaque 105

Plaque Heart attacks Heart Attack Cardiovascular Disease 105

Circulation

NOVEMBER 11, 2024

The sections were also used for immunohistochemistry with cell marker antibodies (to measure % plaque smooth muscle cells (SMC), macrophages (MF), and endothelial cells (EC)). to D: 30.7%), elevation in plaque MF (A: 16.7% to D: 22.5%), increase in plaque cell apoptosis (A: 5.2% to D:17.9%) and plaque EC (A:3.21% to D:1.48%).

Plaque 40

Plaque Atherosclerosis Heart Disease Circulation 40

Cardiometabolic Health Congress

JUNE 20, 2024

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Giovanna Liuzzo (Italy) revealed that advancements in noninvasive imaging recently allow for direct visualization of coronary atherosclerotic plaques. Here are some notable highlights: Prof.

Atherosclerosis 59

Atherosclerosis Cardiovascular Disease Coronary Artery Disease Myocardial Infarction 59

DAIC

OCTOBER 15, 2024

15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. tim.hodson Tue, 10/15/2024 - 12:12 Oct.

Medicare 52

Medicare Plaque Chest Pain Coronary Artery Disease 52

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 105

Coronary Artery Disease Plaque Exercise Heart attacks 105

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Circulation: Cardiovascular Imaging

JANUARY 11, 2024

BACKGROUND:Intensive lipid-lowering therapy may induce coronary atherosclerosis regression. A decrease in the percentage of unstable core (fibro-fatty+necrotic plaque; from 14.1 [7.9–22.3] Nevertheless, the factors underlying the effect of lipid-lowering therapy on disease regression remain poorly characterized. 10.6]; −6.6%;P<0.001)

Plaque 40

Plaque Atherosclerosis Cardiovascular Imaging Cardiovascular Disease 40

Frontiers in Cardiovascular Medicine

JUNE 16, 2024

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques.

Atherosclerosis 52

Atherosclerosis Plaque Physiology Innovation 52

Dr. Paddy Barrett

SEPTEMBER 20, 2024

When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. No atherosclerosis. No heart attacks.

Heart Disease 104

Heart Disease Cholesterol Atherosclerosis Heart Attack 104

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2025

JAK2 mutations in HSCs can lead to CH and correlate with atherosclerosis, but the condition has been difficult to study because of challenges modeling the mutant cells at very low frequency. In this issue of the JCI, Liu et al. In this issue of the JCI, Liu et al.

Plaque 45

Plaque Transplant Atherosclerosis Cardiovascular Disease 45

Dr. Paddy Barrett

JUNE 7, 2024

Heart disease is the presence of plaque or atherosclerosis in the coronary arteries. Over a long enough time horizon, pretty much everyone will develop a significant amount of plaque and have a heart attack. We have very strong evidence to support the idea that the more plaque you have, the greater your risk of a heart attack 1.

Heart Disease 80

Heart Disease Heart Attack Heart attacks Plaque 80

Circulation

DECEMBER 17, 2024

However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown. We explored the mechanism of METTL4 involvement in atherosclerosis usingMettl4Mac-KO-Apoe-/-andMettl4MUT-Apoe-/-mice and cell models, as well as bone marrow transplantation.

Atherosclerosis 40

Atherosclerosis Transplant Plaque Pharmacology 40

Physiologically Speaking

APRIL 10, 2024

people from the general population), coronary artery calcium scores (CACS) are higher, indicating more calcification and the presence of atherosclerotic plaques. Calcified plaques are known to be more stable and less prone to rupture and lead to a heart attack. When comparing athletes to control groups (i.e., hours per week).

Atherosclerosis 52

Atherosclerosis Plaque Exercise Cardiovascular Disease 52