Circulation

NOVEMBER 11, 2024

CCR5, a chemokine receptor, has been associated with both immunosuppressive and inflammatory phenotypes, however, the possible role of CCR5 pertaining to MDSCs in the development of atherosclerosis has not been elucidated yet. Possibly this dysfunctionality contributes to the development and progression of CVD including atherosclerosis.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Medical Xpress - Cardiology

DECEMBER 12, 2023

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.

Heart Attack 105

Heart Attack Heart attacks Atherosclerosis Coronary Artery Disease 105

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Korean Circ J.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

Stroke Journal

FEBRUARY 1, 2024

Ipsilateral and contralateral carotid artery plaque features were compared, then the carotid artery plaque characteristics on the infarct side were correlated with the infarct pattern.Results:the mean age of subjects included was 68 years old, 79.6% of them were male. 0.15), larger wall area (0.50±0.19 0.23), all p values<0.05.

Plaque 40

Plaque Atherosclerosis Stroke Strokes 40

Frontiers in Cardiovascular Medicine

APRIL 4, 2024

Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis.

Atherosclerosis 52

Atherosclerosis Plaque 52

DAIC

OCTOBER 15, 2024

15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. tim.hodson Tue, 10/15/2024 - 12:12 Oct.

Medicare 52

Medicare Plaque Chest Pain Coronary Artery Disease 52

Nature Reviews - Cardiology

JANUARY 1, 2024

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00957-0 Macrophages in atherosclerotic plaques can undergo apoptosis and several forms of regulated necrosis, including necroptosis, pyroptosis and ferroptosis.

Atherosclerosis 86

Atherosclerosis Plaque 86

Circulation

NOVEMBER 11, 2024

Introduction:It remains uncertain whether dietary supplementation of marine n-3 polyunsaturated fatty acids (PUFAs) improves atherosclerosis and lipoprotein subclasses in patients with type 2 diabetes (T2D). The primary outcome was the prevalence of carotid artery plaques assessed by ultrasound. day) or low-dose (1.5g/day)

Atherosclerosis 40

Atherosclerosis Diabetes Plaque Cholesterol 40

Medical Xpress - Cardiology

DECEMBER 13, 2023

Aging is known to be a risk factor for the biological changes that create the dangerous buildup of plaque in arteries called atherosclerosis, and aging also induces a buildup of memory CD8 T cells, a type of immune cell, in mice and humans.

Plaque 100

Plaque Atherosclerosis Risk Factors 100

Science Daily - Heart Disease

NOVEMBER 13, 2024

Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

Cardiovascular Disease 100

Cardiovascular Disease Heart Attack Heart attacks Atherosclerosis 100

Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2024

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. However, such studies are rare and limited to animal experiments.

Plaque 64

Plaque Diabetes Atherosclerosis Stroke 64

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Physiologically Speaking

JANUARY 5, 2024

In this 6-month randomized controlled study, twice-weekly HIIT reduced coronary plaque volume, increased aerobic fitness, and improved body composition in adults with stable heart disease, suggesting benefits for cardiovascular disease progression. Does this greater plaque presence put athletes at a greater risk of CVD events?

Plaque 114

Plaque Physiology Exercise Cholesterol 114

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

Atherosclerosis 58

Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 58

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients.

Plaque 52

Plaque Biomarkers Circulation Stenosis 52

Frontiers in Cardiovascular Medicine

NOVEMBER 1, 2024

BackgroundAtherosclerosis is a leading cause of cardiovascular disease worldwide, while carotid atherosclerosis (CAS) is more likely to cause ischemic cerebrovascular events. Emerging evidence suggests that cuproptosis may be associated with an increased risk of atherosclerotic cardiovascular disease.

Atherosclerosis 52

Atherosclerosis Cardiovascular Disease Plaque Biomarkers 52

Circulation: Cardiovascular Imaging

JANUARY 11, 2024

BACKGROUND:Intensive lipid-lowering therapy may induce coronary atherosclerosis regression. A decrease in the percentage of unstable core (fibro-fatty+necrotic plaque; from 14.1 [7.9–22.3] Nevertheless, the factors underlying the effect of lipid-lowering therapy on disease regression remain poorly characterized. 10.6]; −6.6%;P<0.001)

Plaque 40

Plaque Atherosclerosis Cardiovascular Imaging Cardiovascular Disease 40

Frontiers in Cardiovascular Medicine

JUNE 16, 2024

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques.

Atherosclerosis 52

Atherosclerosis Plaque Physiology Innovation 52

Cardiometabolic Health Congress

JUNE 20, 2024

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Giovanna Liuzzo (Italy) revealed that advancements in noninvasive imaging recently allow for direct visualization of coronary atherosclerotic plaques. Here are some notable highlights: Prof.

Atherosclerosis 59

Atherosclerosis Cardiovascular Disease Coronary Artery Disease Myocardial Infarction 59

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

Atherosclerosis 59

Atherosclerosis Plaque Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

FEBRUARY 8, 2024

Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.

Plaque 59

Plaque Angina Myocardial Infarction Risk Factors 59

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.

Plaque 40

Plaque Thrombosis Atherosclerosis Article 40

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

American College of Cardiology

NOVEMBER 7, 2024

The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).

Myocardial Infarction 61

Myocardial Infarction Atherosclerosis Plaque Article 61

Science Daily - Heart Disease

SEPTEMBER 18, 2024

The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

Cardiovascular Disease 113

Cardiovascular Disease Atherosclerosis Plaque Risk Factors 113

Physiologically Speaking

APRIL 10, 2024

people from the general population), coronary artery calcium scores (CACS) are higher, indicating more calcification and the presence of atherosclerotic plaques. Calcified plaques are known to be more stable and less prone to rupture and lead to a heart attack. When comparing athletes to control groups (i.e., hours per week).

Atherosclerosis 52

Atherosclerosis Plaque Exercise Cardiovascular Disease 52

Frontiers in Cardiovascular Medicine

JUNE 12, 2024

Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated.

Atherosclerosis 52

Atherosclerosis Plaque Research 52

Journal of the American Heart Association

DECEMBER 8, 2023

BackgroundThe relationship between depression and subclinical coronary atherosclerosis in asymptomatic individuals is not clear. The degree and extent of subclinical coronary atherosclerosis were evaluated by coronary computed tomographic angiography, and ≥50% diameter stenosis was defined as significant. 2.03];P=0.450).

Coronary Artery Disease 40

Coronary Artery Disease Atherosclerosis Plaque Stenosis 40

HCPLive

APRIL 24, 2024

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

Atherosclerosis 64

Atherosclerosis Plaque 64

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. Ultrasonography was applied to assess the AS, including thickened IMT (TIMT) and plaque in the carotid and femoral arteries.

Atherosclerosis 49

Atherosclerosis Plaque Hypertension Blood Pressure 49

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

IntroductionMechanical stress and strain conditions play an important role in atherosclerosis plaque progression, remodeling and potential rupture and may be used in plaque vulnerability assessment for better clinical diagnosis and treatment decisions. Further large-scale studies are needed to validate our findings.

Plaque 40

Plaque Atherosclerosis 40

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundUltraviolet B (UV‐B) irradiation is an effective treatment for human cutaneous disorders and was shown to reduce experimental atherosclerosis by attenuating immunoinflammatory responses. Our findings indicate that a novel 282 nm UV‐B phototherapy could be an attractive approach to treat atherosclerosis.

Atherosclerosis 45

Atherosclerosis Plaque Aortic Technology 45

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Notably, Apoe–/– mice expressing LL37 developed larger atheroma plaques than did control mice, and a positive correlation between plasma LL37 and oxidized phospholipid on apolipoprotein B (OxPL-apoB) levels was observed in individuals with cardiovascular disease.

Atherosclerosis 122

Atherosclerosis Cholesterol Cardiovascular Disease Plaque 122

Frontiers in Cardiovascular Medicine

JANUARY 24, 2024

Background Although atherosclerosis (AS) can affect multiple vascular beds, previous studies have focused on the analysis of single-site AS plaques. The plaques were then categorized into culprit plaques, non-culprit plaques, and non-event plaques.

Plaque 59

Plaque Stenosis Hemorrhage Atherosclerosis 59

Stroke Journal

FEBRUARY 1, 2024

Background:Most ischemic strokes are caused by atherosclerosis. Atherosclerotic plaque formation is modulated by genetic and environmental interactions. Apolipoprotein E (ApoE) regulates lipid metabolism, and its deficiency is associated with dyslipidemia and atherosclerosis.

Atherosclerosis 40

Atherosclerosis Risk Factors Diet Plaque 40

NEJM Journal Watch - Cardiology

OCTOBER 24, 2024

Any atherosclerotic plaque is bad, and its presence portends a worse prognosis if modifiable risk factors like hypertension and smoking are not addressed.

Atherosclerosis 40

Atherosclerosis Plaque Risk Factors Hypertension 40