Physiologically Speaking

JANUARY 5, 2024

In this 6-month randomized controlled study, twice-weekly HIIT reduced coronary plaque volume, increased aerobic fitness, and improved body composition in adults with stable heart disease, suggesting benefits for cardiovascular disease progression. Does this greater plaque presence put athletes at a greater risk of CVD events?

Plaque 119

Plaque Physiology Exercise Cholesterol 119

Medical Xpress - Cardiology

DECEMBER 13, 2023

Aging is known to be a risk factor for the biological changes that create the dangerous buildup of plaque in arteries called atherosclerosis, and aging also induces a buildup of memory CD8 T cells, a type of immune cell, in mice and humans.

Plaque 100

Plaque Atherosclerosis Risk Factors 100

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2025

IntroductionCardiovascular disease (CVD) caused by atherosclerosis (AS) remains the leading cause of mortality in developed countries. Targeting this cell-cell interaction may offer new therapeutic avenues for managing atherosclerosis. These macrophages were associated with lipid transport, storage, and cell migration pathways.

Atherosclerosis 40

Atherosclerosis Plaque Research 40

Science Daily - Heart Disease

NOVEMBER 13, 2024

Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

Cardiovascular Disease 113

Cardiovascular Disease Heart attacks Heart Attack Plaque 113

Science Daily - Heart Disease

SEPTEMBER 18, 2024

The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

Cardiovascular Disease 122

Cardiovascular Disease Plaque Atherosclerosis Risk Factors 122

Science Daily - Stroke

FEBRUARY 25, 2025

CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway -- with therapeutic potential.

Plaque 52

Plaque Atherosclerosis Research 52

Medical Xpress - Cardiology

FEBRUARY 13, 2025

Atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events.

Atherosclerosis 59

Atherosclerosis Plaque 59

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Notably, Apoe–/– mice expressing LL37 developed larger atheroma plaques than did control mice, and a positive correlation between plasma LL37 and oxidized phospholipid on apolipoprotein B (OxPL-apoB) levels was observed in individuals with cardiovascular disease.

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Atherosclerosis Cholesterol Cardiovascular Disease Plaque 121

Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2024

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. However, such studies are rare and limited to animal experiments.

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Plaque Diabetes Atherosclerosis Strokes 64

CTVS

OCTOBER 30, 2024

Common examples of vascular disease are aneurysms (a dangerous bulge in an artery wall), atherosclerosis (plaque buildup in the… Source Vascular disease affects the body’s vast network of blood vessels, veins and arteries.

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Aneurysm Plaque Atherosclerosis Heart Disease 52

Frontiers in Cardiovascular Medicine

JULY 24, 2024

Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed.

Atherosclerosis 52

Atherosclerosis Plaque Coronary Artery Disease Risk Factors 52

CTVS

APRIL 22, 2025

PAD causes a narrowing of the peripheral arteries due to fatty plaque buildup (or atherosclerosis) which restricts blood flow to the extremities. PAD (Peripheral Artery Disease) is a common circulatory condition affecting more than 10 million Americans. This can lead to… Source

Peripheral Arterial Disease 40

Peripheral Arterial Disease Plaque Atherosclerosis 40

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

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Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 60

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

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Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Frontiers in Cardiovascular Medicine

APRIL 4, 2024

Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis.

Atherosclerosis 52

Atherosclerosis Plaque 52

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

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Cholesterol Atherosclerosis Plaque 72

Dr. Smith's ECG Blog

SEPTEMBER 18, 2024

Thus, it has recently become generally accepted that most plaque ruptures resulting in myocardial infarction occur in plaques that narrow the lumen diameter by 40% of the arterial cross section may be involved by plaque. The pathologist may see a plaque that constitutes, for example, 50% of the cross-sectional area.

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Ischemia Plaque Stenosis Myocardial Infarction 121

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients.

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Plaque Biomarkers Circulation Stenosis 52

HCPLive

APRIL 24, 2024

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

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Atherosclerosis Plaque 64

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Korean Circ J.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

American College of Cardiology

APRIL 23, 2025

A high baseline level of high-sensitivity C-reactive protein (hsCRP) may indicate pan-coronary atherosclerosis and focal high-risk plaques in patients with a recent NSTEMI, according to a substudy of PROSPECT II published April 23.

Plaque 40

Plaque Atherosclerosis Article 40

Circulation

NOVEMBER 11, 2024

The sections were also used for immunohistochemistry with cell marker antibodies (to measure % plaque smooth muscle cells (SMC), macrophages (MF), and endothelial cells (EC)). to D: 30.7%), elevation in plaque MF (A: 16.7% to D: 22.5%), increase in plaque cell apoptosis (A: 5.2% to D:17.9%) and plaque EC (A:3.21% to D:1.48%).

Plaque 40

Plaque Atherosclerosis Heart Disease Circulation 40

Stroke Journal

FEBRUARY 1, 2024

Ipsilateral and contralateral carotid artery plaque features were compared, then the carotid artery plaque characteristics on the infarct side were correlated with the infarct pattern.Results:the mean age of subjects included was 68 years old, 79.6% of them were male. 0.15), larger wall area (0.50±0.19 0.23), all p values<0.05.

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Plaque Atherosclerosis Strokes Stroke 40

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

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Risk Factors Heart Disease Heart attacks Heart Attack 111

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

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Atherosclerosis Plaque Cardiovascular Disease 59

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 105

Coronary Artery Disease Plaque Exercise Heart attacks 105

Frontiers in Cardiovascular Medicine

JUNE 16, 2024

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques.

Atherosclerosis 52

Atherosclerosis Plaque Physiology Innovation 52

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Frontiers in Cardiovascular Medicine

JUNE 12, 2024

Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated.

Atherosclerosis 52

Atherosclerosis Plaque Research 52

Circulation: Cardiovascular Imaging

JANUARY 11, 2024

BACKGROUND:Intensive lipid-lowering therapy may induce coronary atherosclerosis regression. A decrease in the percentage of unstable core (fibro-fatty+necrotic plaque; from 14.1 [7.9–22.3] Nevertheless, the factors underlying the effect of lipid-lowering therapy on disease regression remain poorly characterized. 10.6]; −6.6%;P<0.001)

Plaque 40

Plaque Atherosclerosis Cardiovascular Imaging Cardiovascular Disease 40

Circulation

NOVEMBER 11, 2024

CCR5, a chemokine receptor, has been associated with both immunosuppressive and inflammatory phenotypes, however, the possible role of CCR5 pertaining to MDSCs in the development of atherosclerosis has not been elucidated yet. Possibly this dysfunctionality contributes to the development and progression of CVD including atherosclerosis.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Journal of the American Heart Association

FEBRUARY 26, 2025

BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Journal of the American Heart Association, Ahead of Print. Small dense lowdensity lipoprotein cholesterol (sdLDLC) is considered as the most atherogenic lipoprotein.

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Ultrasound Plaque Cholesterol Coronary Artery Disease 56

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. Ultrasonography was applied to assess the AS, including thickened IMT (TIMT) and plaque in the carotid and femoral arteries.

Atherosclerosis 49

Atherosclerosis Plaque Hypertension Blood Pressure 49

Circulation

DECEMBER 17, 2024

However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown. We explored the mechanism of METTL4 involvement in atherosclerosis usingMettl4Mac-KO-Apoe-/-andMettl4MUT-Apoe-/-mice and cell models, as well as bone marrow transplantation.

Atherosclerosis 40

Atherosclerosis Transplant Plaque Pharmacology 40

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.

Plaque 40

Plaque Thrombosis Atherosclerosis Article 40

American College of Cardiology

NOVEMBER 7, 2024

The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).

Myocardial Infarction 58

Myocardial Infarction Atherosclerosis Plaque Article 58

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundUltraviolet B (UV‐B) irradiation is an effective treatment for human cutaneous disorders and was shown to reduce experimental atherosclerosis by attenuating immunoinflammatory responses. Our findings indicate that a novel 282 nm UV‐B phototherapy could be an attractive approach to treat atherosclerosis.

Atherosclerosis 45

Atherosclerosis Plaque Aortic Technology 45