Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2024

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. However, such studies are rare and limited to animal experiments.

Plaque 64

Plaque Diabetes Atherosclerosis Stroke 64

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Physiologically Speaking

JANUARY 5, 2024

In this 6-month randomized controlled study, twice-weekly HIIT reduced coronary plaque volume, increased aerobic fitness, and improved body composition in adults with stable heart disease, suggesting benefits for cardiovascular disease progression. Does this greater plaque presence put athletes at a greater risk of CVD events?

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Plaque Physiology Exercise Cholesterol 117

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. miRNA expression profiles of serum-derived EVs were obtained by small RNA sequencing and in plaque material simultaneously acquired from patients.

Plaque 52

Plaque Circulation Biomarkers Stenosis 52

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

Atherosclerosis 57

Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 57

Frontiers in Cardiovascular Medicine

JUNE 16, 2024

In recent years, the role of macrophages as the primary cell type contributing to foam cell formation and atheroma plaque development has been widely acknowledged. Recent studies have further supported the notion that SMCs constitute the majority of foam cells in advanced atherosclerotic plaques.

Atherosclerosis 52

Atherosclerosis Plaque Physiology Innovation 52

Cardiometabolic Health Congress

JUNE 20, 2024

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Giovanna Liuzzo (Italy) revealed that advancements in noninvasive imaging recently allow for direct visualization of coronary atherosclerotic plaques. Here are some notable highlights: Prof.

Atherosclerosis 59

Atherosclerosis Cardiovascular Disease Coronary Artery Disease Myocardial Infarction 59

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

Atherosclerosis 59

Atherosclerosis Plaque Cardiovascular Disease 59

Science Daily - Heart Disease

SEPTEMBER 18, 2024

The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

Cardiovascular Disease 110

Cardiovascular Disease Atherosclerosis Plaque Risk Factors 110

Frontiers in Cardiovascular Medicine

FEBRUARY 8, 2024

Objective Assessing the impact of lumbar disc herniation (LDH) on the plaque burden of coronary atherosclerosis is our objective. Gensini scores were calculated to assess the plaque burden of coronary. The association between lumbar disc lesions grading and coronary plaque burden was analysed by Spearman's correlation test.

Plaque 59

Plaque Angina Myocardial Infarction Risk Factors 59

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.

Plaque 40

Plaque Thrombosis Atherosclerosis Article 40

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Method Different dosages of colchicine mixed with cholesterol (0.05–5 mg/ml/g

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Cholesterol Atherosclerosis Plaque 72

Frontiers in Cardiovascular Medicine

JUNE 12, 2024

Atherosclerosis (AS) is a complex disease caused by multiple pathological factors threatening human health-the pathogenesis is yet to be fully elucidated.

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Atherosclerosis Plaque Research 52

Physiologically Speaking

APRIL 10, 2024

people from the general population), coronary artery calcium scores (CACS) are higher, indicating more calcification and the presence of atherosclerotic plaques. Calcified plaques are known to be more stable and less prone to rupture and lead to a heart attack. When comparing athletes to control groups (i.e., hours per week).

Atherosclerosis 52

Atherosclerosis Plaque Exercise Cardiovascular Disease 52

Journal of the American Heart Association

DECEMBER 8, 2023

BackgroundThe relationship between depression and subclinical coronary atherosclerosis in asymptomatic individuals is not clear. The degree and extent of subclinical coronary atherosclerosis were evaluated by coronary computed tomographic angiography, and ≥50% diameter stenosis was defined as significant. 2.03];P=0.450).

Coronary Artery Disease 40

Coronary Artery Disease Atherosclerosis Plaque Stenosis 40

HCPLive

APRIL 24, 2024

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

Atherosclerosis 64

Atherosclerosis Plaque 64

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. Ultrasonography was applied to assess the AS, including thickened IMT (TIMT) and plaque in the carotid and femoral arteries.

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Atherosclerosis Plaque Hypertension Blood Pressure 49

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundUltraviolet B (UV‐B) irradiation is an effective treatment for human cutaneous disorders and was shown to reduce experimental atherosclerosis by attenuating immunoinflammatory responses. Our findings indicate that a novel 282 nm UV‐B phototherapy could be an attractive approach to treat atherosclerosis.

Atherosclerosis 45

Atherosclerosis Plaque Aortic Technology 45

Stroke Journal

FEBRUARY 1, 2024

Background:Most ischemic strokes are caused by atherosclerosis. Atherosclerotic plaque formation is modulated by genetic and environmental interactions. Apolipoprotein E (ApoE) regulates lipid metabolism, and its deficiency is associated with dyslipidemia and atherosclerosis.

Atherosclerosis 40

Atherosclerosis Risk Factors Diet Plaque 40

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Notably, Apoe–/– mice expressing LL37 developed larger atheroma plaques than did control mice, and a positive correlation between plasma LL37 and oxidized phospholipid on apolipoprotein B (OxPL-apoB) levels was observed in individuals with cardiovascular disease.

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Atherosclerosis Cholesterol Cardiovascular Disease Plaque 115

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. Carotid ultrasound results were divided into two groups based on the presence or absence of plaque. Carotid plaque was observed in 1140 (43.5%) subjects and CACS>0 in 1172 (44.7%) subjects.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Journal of Cardiovascular Pharmacology

NOVEMBER 26, 2023

Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated. Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated.

Atherosclerosis 40

Atherosclerosis Stent Stents Plaque 40

Dr. Paddy Barrett

SEPTEMBER 20, 2024

When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. No atherosclerosis. No heart attacks.

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Heart Disease Cholesterol Atherosclerosis Heart Attack 99

DAIC

JULY 18, 2024

This registry will aim to provide world-wide physicians the most accurate information on coronary plaque to improve cardiovascular risk prediction and support the selection of patient-specific treatment,” said Dr. De Cecco. The ultimate goal is to positively impact cardiovascular health globally with a reduction in cardiovascular events."

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Plaque Heart Attack Heart attacks Cardiovascular Disease 105

CTVS

SEPTEMBER 17, 2024

PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source

Peripheral Arterial Disease 52

Peripheral Arterial Disease Atherosclerosis Plaque Cholesterol 52

Dr. Paddy Barrett

JUNE 7, 2024

Heart disease is the presence of plaque or atherosclerosis in the coronary arteries. Over a long enough time horizon, pretty much everyone will develop a significant amount of plaque and have a heart attack. We have very strong evidence to support the idea that the more plaque you have, the greater your risk of a heart attack 1.

Heart Disease 74

Heart Disease Heart Attack Heart attacks Plaque 74

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 105

Coronary Artery Disease Plaque Exercise Heart Attack 105

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

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Risk Factors Heart Disease Heart Attack Heart attacks 105

Stroke Journal

FEBRUARY 1, 2024

Background:Intracranial Atherosclerosis (ICAS) leads to stroke by perforator disease, artery to artery embolism, and impaired distal flow/perfusion. While medical treatment is likely to stabilize atherosclerotic plaques, it is unlikely to improve distal perfusion in the acute setting.

Atherosclerosis 40

Atherosclerosis Embolism Stroke Strokes 40

Dr. Paddy Barrett

OCTOBER 4, 2024

Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.

Heart Disease 72

Heart Disease Plaque Cholesterol Risk Factors 72

Frontiers in Cardiovascular Medicine

FEBRUARY 1, 2024

Coronary atherosclerosis remains a leading cause of morbidity and mortality worldwide. We sought to provide an overview of the inflammatory pathobiology of atherosclerosis, distinct high-risk plaque features and the ability to visualize this process with contemporary intracoronary imaging techniques.

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Atherosclerosis Plaque 64

Cardiovascular Diabetology

JULY 3, 2024

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.

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Cholesterol Diabetes Atherosclerosis Plaque 45

Frontiers in Cardiovascular Medicine

JUNE 26, 2024

ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. In the pathogenesis of atherosclerosis, inflammation assumes a pivotal role, not solely in the initiation and complications of atherosclerotic plaque formation, but also in the myocardial response to ischemic insult.

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Plaque Myocardial Infarction Atherosclerosis Heart Failure 52

Heart 2023 Conference

MARCH 17, 2023

Atherosclerosis, also called " hardening of the arteries, " occurs when fat, cholesterol and other substances are deposited in the walls of the arteries. These deposits are called plaques. Over time, these plaques can narrow or completely block arteries and cause problems throughout the body. Atherosclerosis is a common disease.

Atherosclerosis 52

Atherosclerosis Exercise Plaque Cholesterol 52

Dr. Paddy Barrett

AUGUST 1, 2023

A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. A CT CAC scan of 0 indicates no significant amount of calcified atherosclerosis.

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Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Frontiers in Cardiovascular Medicine

FEBRUARY 7, 2024

At the patient level, those with reduced CFR showed a significantly higher prevalence of diffused atherosclerosis (41% vs. 23%; P  < 0.001) and higher FAI (−75.5 HU In the patient-level analysis, obstructive CAD, diffused atherosclerosis, and FAI were independently linked with CFR. Results We detected a decrease in CFR (<2.5)

Coronary Artery Disease 64

Coronary Artery Disease Atherosclerosis Plaque Risk Factors 64