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Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice

Journal of Clinical Investigation - Cardiology

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Consistent with this mechanism, deletion of endothelial ATGL markedly increased lesion size in a model of atherosclerosis.

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Physiology Friday #206: Is Too Much Protein Damaging to Your Arteries?

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Previous research found that a high-protein diet promoted a cardiovascular disease known as atherosclerosis…in mice who were genetically predisposed to developing the disease. Does this same mechanism exist in humans?

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Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque

Physiologically Speaking

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. LDL and ApoB — which play an obligate and causal role in the development of atherosclerosis — weren’t affected by exercise. ” Details can be found at the end of the post!

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Physiology Friday #213: Stair Climbing 'Exercise Snacks' Increase VO2 Max

Physiologically Speaking

Welcome to the Physiology Friday newsletter. ICYMI On Wednesday, I published a post about the recent evidence on high-volume exercise and atherosclerosis in athletes. Physiologically Speaking is a reader-supported publication.

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Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease?

Journal of Clinical Investigation - Cardiology

The physiology of lipid droplets (LDs) has been most extensively characterized in adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to changing levels of triglycerides. Boutagy, Gamez-Mendez, et al.

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Mechanisms modulating foam cell formation in the arterial intima: exploring new therapeutic opportunities in atherosclerosis

Frontiers in Cardiovascular Medicine

Given that SMCs are a major component of the vascular wall, they serve as a significant source of microvesicles and exosomes, which have the potential to regulate the physiology of other vascular cells. These innovative strategies hold promise for improving the management of atherosclerosis in the near future.

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A novel degradable PEG superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE), to treat ROS-driven cardiovascular-diseases, tested in atherosclerosis as a model disease, and hypothesizing autoimmunity as an atheroma's trigger

Frontiers in Cardiovascular Medicine

It is proven challenging managing chronic cardiovascular illnesses like atherosclerosis, arrhythmias, and diverse cardiomyopathies. Several approaches have been found in the current literature, aiming at improving physiological acceptance, i.e., to reduce toxicity. In certain cases, there is no approved treatment.