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Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Consistent with this mechanism, deletion of endothelial ATGL markedly increased lesion size in a model of atherosclerosis.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Previous research found that a high-protein diet promoted a cardiovascular disease known as atherosclerosis…in mice who were genetically predisposed to developing the disease. Does this same mechanism exist in humans?
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. LDL and ApoB — which play an obligate and causal role in the development of atherosclerosis — weren’t affected by exercise. ” Details can be found at the end of the post!
Welcome to the Physiology Friday newsletter. ICYMI On Wednesday, I published a post about the recent evidence on high-volume exercise and atherosclerosis in athletes. Physiologically Speaking is a reader-supported publication.
The physiology of lipid droplets (LDs) has been most extensively characterized in adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to changing levels of triglycerides. Boutagy, Gamez-Mendez, et al.
Given that SMCs are a major component of the vascular wall, they serve as a significant source of microvesicles and exosomes, which have the potential to regulate the physiology of other vascular cells. These innovative strategies hold promise for improving the management of atherosclerosis in the near future.
It is proven challenging managing chronic cardiovascular illnesses like atherosclerosis, arrhythmias, and diverse cardiomyopathies. Several approaches have been found in the current literature, aiming at improving physiological acceptance, i.e., to reduce toxicity. In certain cases, there is no approved treatment.
Once perceived as a mere conduit for interstitial fluid and immune cell transport, recent research has unveiled its active involvement in critical physiological processes and common diseases, including inflammation, autoimmune diseases, and atherosclerosis.
Such fibrils are associated with major human diseases including Alzheimer’s and Parkinson’s diseases, diabetes, and heart diseases such as atherosclerosis and calcific aortic valve disease. “We
The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved in various physiological and pathological processes.
The Category I CPT code is an addition to the Category III CPT codes (CPT 0623T, 0624T, 0625T, 0626T) used for reporting Cleerly’s advanced coronary atherosclerosis analysis. Prior studies have demonstrated the independent and incremental benefit of Cleerly ISCHEMIA applied to CCTA beyond traditional assessment.
1 Atherosclerosis is a systemic disease that affects multiple vascular regions and is particularly severe in PAD patients, where up to 80 percent suffer from concurrent coronary artery disease (CAD), historically linked with a mortality rate exceeding 50 percent within five years.
Cardiovascular disease is the most common cause of death and disability globally, largely driven by myocardial infarction and ischemic stroke caused by atherosclerosis (plaque build-up in the arteries).
ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. Hypertension, Ahead of Print.
While traditional vascular risk factors (eg, hypertension, dyslipidemia, tobacco use) account for 20% of the explained variance in carotid atherosclerosis, they remain a prominent focus for primary and secondary ischemic stroke prevention strategies.
Dysregulation of β-arrestin signaling has been linked to several cardiovascular diseases including hypertension, atherosclerosis, and heart failure. In this review, we will discuss the beneficial and maladaptive physiological outcomes of angiotensin-II type 1 receptor-dependent β-arrestin activation in different cardiovascular diseases.
Exercise perturbs our entire physiology, and it’s this disruption of homeostasis, integrative crosstalk, and subsequent adaptations that lead to the immense health benefits achieved through physical activity. Mimicking exercise: what matters most and where to next? Mimicking exercise: what matters most and where to next?
LDL is obviously a target against atherosclerosis. definitely deserve the name bad cholesterol.The good news is, it may be counting its last few decades, as the whole pharma industry is activated to destroy this physiological molecule that carries some critical functions in our body. Preamble 15 % of body weight is fat. Reference 1.Lib
So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Atherosclerosis is not a worrisome issue as long as it is contained deep within the vessel wall and doesn’t encroach the lumen. Atherosclerosis. to decode the histological, biochemical, pathological secrets within the atherosclerotic plaques.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Exercise and Coronary Atherosclerosis | Circulation What’s lacking, however, is good data on long-term survival and lifespan among “extreme exercisers.”
The amount of calcium in the blood vessels (known as arterial calcification), a marker of subclinical atherosclerosis, is higher in people with a short sleep duration. 14 One study of over 1,900 men found evidence that very short sleep duration predicts a higher burden of atherosclerosis in their coronary and femoral arteries.
Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease. The Latest Evidence on Atherosclerosis in Athletes The risk factor component is yet unexplored—how do risk factors other than training contribute to elevated CAC in endurance athletes?
Background The relationship between atherosclerosis and endotypes of myocardial ischaemia with no obstructive coronary artery disease (INOCA) is unclear. A comprehensive physiological assessment was performed using both a thermodilution-based diagnostic guidewire and intracoronary acetylcholine provocation testing. smoking, 63.6%
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