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METTL4-Mediated Mitochondrial DNA N6-Methyldeoxyadenosine Promoting Macrophage Inflammation and Atherosclerosis

Circulation

However, the role of METTL4-mediated mitoepigenetic regulation in atherosclerosis is still unknown. We explored the mechanism of METTL4 involvement in atherosclerosis usingMettl4Mac-KO-Apoe-/-andMettl4MUT-Apoe-/-mice and cell models, as well as bone marrow transplantation.

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Network pharmacology to unveil the blood components and mechanisms of Tongmai Yangxin Pills in treating elderly coronary heart disease

Frontiers in Cardiovascular Medicine

Then, we collected literature-validated TMYXP blood component targets for further network pharmacology analysis.ResultsAll blood components of TMYXP exhibited non-toxic properties. This study focused on peripheral blood mononuclear cell samples from 6 elderly patients with CHD over 60 years old (GSE142008).