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Atherosclerosis (ASVD) remains a leading driver of cardiovascular disease (CVD), a global health challenge that claims millions of lives each year. Precision Medicine: Personalizing Prevention for Better Outcomes Precision medicine provides tools to customize prevention and treatment plans based on individual risk factors.
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
milla1cf Tue, 03/26/2024 - 13:00 March 26, 2024 — Esperion announced the acceptance of three CLEAR ( C holesterol L owering via B e mpedoic acid, an A CL-Inhibiting R egimen ) Outcomes subgroup analyses as poster presentations at th e 2024 American College of Cardiology’s Annual Scientific Session ( ACC.24 24 ) in Atlanta, Georgia.
BackgroundAbdominal aortic calcification (AAC), an early indicator of abdominal aortic wall atherosclerosis, is a marker of subclinical atherosclerosis and a predictive factor for vascular-associated morbidity and mortality. These outcomes are driven by inflammatory processes.
Evidence suggests SCH may exacerbate atherosclerosis and cardiac dysfunction through mechanisms such as increased LDL synthesis, oxidative stress, and impaired vascular endothelial function. However, the causal link between SCH and cardiovascular outcomes remains unclear due to study design heterogeneity and overreliance on TSH levels.
Furthermore, prospective clinical trials of statin-mediated lipid lowering have repeatedly failed to provide any benefit in AS outcomes. This unmet clinical need for pharmacotherapeutic strategies tailored specifically to AS has spurred contemporary efforts to unravel the development of this disease from atherosclerosis.
We hypothesized that intracranial atherosclerosis, which is seen predominantly in older patients, affects vasospasm risk in aSAH. Intracranial atherosclerosis burden was quantified by using modified Woodcock (MW) score on CT angiograms measured by trained assessors. Worse outcome was defined as 3-month modified Rankin Scale 4-6.
Background Heart failure with preserved ejection fraction is a recognised outcome in patients with myocardial infarction, although heart failure with reduced ejection fraction is more common.
We conducted a post hoc analysis of RICAMIS to investigate whether large artery atherosclerosis (LAA) subtype contributed to the outcomes.METHODS:This is a post hoc analysis of the RICAMIS trial. The primary outcome was excellent functional outcome at 90 days, defined as modified Rankin Scale score of 0 to 1. were women.
Introduction:It remains uncertain whether dietary supplementation of marine n-3 polyunsaturated fatty acids (PUFAs) improves atherosclerosis and lipoprotein subclasses in patients with type 2 diabetes (T2D). The primary outcome was the prevalence of carotid artery plaques assessed by ultrasound. day) or low-dose (1.5g/day)
Background:Intracranial atherosclerosis (ICAS) is a common stroke cause, with a recurrent stroke risk of up to 18% per year despite treatment advances. The primary outcome was the incidence of stroke. Conclusions:Lipid-lowering therapies significantly reduce the risk of ischemic stroke in patients with intracranial atherosclerosis.
IntroductionCerebrovascular disease (CVD), particularly carotid artery atherosclerosis, contributes substantially to global morbidity and mortality. The ability to precisely detect atherosclerosis is crucial, as it directly influences patient management, including decisions regarding surgical interventions.
European Atherosclerosis Society (EAS) Congress 2024 Date: May 26-29, 2024 Location: Lyon, France and online Overview: The European Atherosclerosis Society (EAS) and the New French Society of Atherosclerosis will be hosting the 92 nd EAS Congress, to be held in the city of Lyon. Hashtag: #ICNCCT2024 7.
BackgroundChronic inflammatory disease (CID) accelerates atherosclerosis and the development of aortic stenosis. Data on long‐term outcomes after transcatheter aortic valve implantation (TAVI) in those patients are missing. Long‐term (up to 5 years) clinical and echocardiographic outcomes were studied.
Stroke subtype was examined using TOAST classification: 1) large artery atherosclerosis; 2) cardioembolic; 3) small vessel occlusion; 4) other known etiology (e.g., Compared to the pre-COVID period, the COVID period had a lower proportion of strokes from large artery atherosclerosis (17.6% vs. 21.2%, p=0.02) during the COVID period.
Background:Intracranial Atherosclerosis (ICAS) leads to stroke by perforator disease, artery to artery embolism, and impaired distal flow/perfusion. The study outcome is recurrent ischemic stroke. Stroke, Volume 55, Issue Suppl_1 , Page ATMP72-ATMP72, February 1, 2024. Patients generally underwent perfusion imaging with MRI.
We explored differences in clinical outcomes and successful recanalization rates between EVT and MM.Methods:From SELECT2 randomized clinical trial, patients were categorized based on Stroke etiology: Large-artery atherosclerosis (LAA), Cardioembolism (CE), Stroke of other determined etiology (SOE), and Stroke of undetermined etiology (SUE).
Publication date: Available online 23 June 2024 Source: The American Journal of Cardiology Author(s): Ebenezer Oni, Ellen Boakye, Gregg S. Pressman, Zeina Dardari, Kunal Jha, Moyses Szklo, Matthew Budoff, Khurram Nasir, Timothy M. Hughes, Michael J.
IntroductionIntracranial atherosclerosis‐related large vessel occlusion (ICAS‐LVO) is a common cause of failed mechanical thrombectomy (MT) in acute ischemic stroke (AIS) [1]. Treatment of ICAS‐LVO with rescue stenting and/or angioplasty has shown promising outcomes, but diagnosing ICAS‐LVO during MT can be challenging [2, 3].
The most common category under the TOAST criteria was large artery atherosclerosis (39.2%). of patients.Conclusion:Our data suggests that CRIS may have a higher association with large artery atherosclerosis. Among the cocaine-positive cohort, 10.8% of patients received thrombolytics and 18.9% underwent endovascular thrombectomy.
1) Nevertheless, published research on endovascular treatment outcomes in this population is scarce. 2, 3) In this study, we compared the clinical outcomes of TL patients with the two etiologies.MethodsA retrospective analysis was performed on a multicenter cohort of patients with TLs who underwent endovascular treatment.
Background:The association between left ventricular injury (LVI) detected by cardiac magnetic resonance imaging (CMR) and the risk of a subsequent ischemic stroke is unknown.Methods:We studied stroke-free participants in the Multi-Ethnic Study of Atherosclerosis study who underwent a steady-state free precession CMR at Exam 5 (2010-2012).
2 Molarity assay aligns with Roches commitment to lead with science in order to develop transformational solutions that help improve patient outcomes and simplify lab operations. The development of the Tina-quant Lipoprotein (a) Gen.2 2022 Aug, 80 (9) 934946 Kronenberg F.
Steno-occlusive changes in the posterior cerebral arteries (PCAs) may contribute to worsened outcomes in patients with MMD; however, there is little information on the incidence and natural history of posterior circulation MMD (PCMMD). Demographics, perioperative outcomes, and radiological phenotypes were recorded for 770 patients.
Accurate prediction of stroke recurrence is critical for improving patient outcomes through timely and targeted interventions. The study outcome was recurrent ischemic stroke by day 30. Background:Symptomatic intracranial atherosclerotic disease carries a high stroke recurrence rate. Variables with p<0.05
Gestational diabetes is a common medical complication of pregnancy that is associated with adverse perinatal outcomes and an increased risk of metabolic diseases and atherosclerosis in adult offspring. The mechanisms responsible for this delayed pathological transmission remain unknown.
Patients with acute basilar artery occlusion were classified into three groups according to stroke etiology: large-artery atherosclerosis (LAA), cardioembolism (CE), and undetermined/other determined cause (UC/ODC). The primary outcome was favorable outcome (modified Rankin scale 0-3) at 90 days. 6.71), CE group (52.2%
METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.
In this study, we examined the rates of ischemic stroke in the territory of the qualifying artery (SIT) periprocedurally as well as over time between MMT alone and stent+MMT.Methods:The primary outcome of interest was SIT. Periprocedural stroke was defined as <7d from stent placement.
We assessed the clinical outcomes of endovascular treatment in acute large vessel occlusion (LVO) strokes caused by ICAD and compared them with large vessel occlusion strokes not associated with intracranial atherosclerosis (non-ICAD LVO).Methods:Our vs. 4%, p = 0.008). 1.13, p=0.118).Conclusion:Our 1.13, p=0.118).Conclusion:Our
The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide.
31 patients (18%) had stroke etiology as Large Artery Atherosclerosis (per TOAST criteria). In contrast, patients for whom TOAST criteria was not “Large Artery Atherosclerosis”, had a median initial NIHSS 9 and median discharge NIHSS 2. Further studies are needed to determine why young adults with LVO with LAA have worse outcomes.
BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. Journal of the American Heart Association, Ahead of Print. In multivariate analysis, low CCDR (hazard ratio, 2.21 [95% CI, 0.99–4.92],P=0.04)
Keynote speaker and atherosclerosis expert Peter Libby, MD , captivated the audience with an update on his research into inflammation and atherosclerosis. He discussed therapeutic options not only for treating atherosclerosis but also for preventing cardiovascular disease. Ballantyne, MD , explored Lipoprotein(a).
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We conducted analysis on the determinants of high-risk coronary calcification, represented by CAC score, among women as a step to improve their outcomes and prognosis.
And the more you exercise, the better your outcomes. On the other hand, people who already have CVD or have suffered a CVD event can significantly improve their long-term outcomes by adopting a structured exercise program. One the one hand, participating in aerobic and resistance exercise reduce the incidence of CVD.
BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. Intensive control of sdLDLC along with other risk factors should be considered to mitigate PP and improve cardiovascular outcomes. Journal of the American Heart Association, Ahead of Print.
The conference will equip health professionals with clinical strategies that promote comprehensive health and tools to harness new therapies to improve our collective health outcomes. Michos, MD, MHS, FACC, FAHA, FASE, FASPC ; famed hypertension expert Keith C.
BackgroundResolvin D2 (RvD2) has been reported to protect against the development of atherosclerosis in animal models. Adjusted hazard ratios and 95% CIs for ASCVD outcomes according to baseline RvD2 levels were calculated using Cox proportional hazards models. Journal of the American Heart Association, Ahead of Print.
The complications of the procedure and patient’s outcomes were discussed.MethodsWe identified two patients who were admitted to our medical center between January 2022 to December 2022 for subclavian‐carotid artery bypass procedure. Clinical data were reviewed retrospectively.ResultsCase 1.
Identifying new targeted therapeutic approaches has become a priority of biomedical research to improve patient outcomes and quality of life. Cardiovascular disease (CVD) represents the leading cause of mortality and disability all over the world.
Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. Accumulating evidence suggests that an imbalance of neuroprotective and neuroinflammatory cytokines may contribute to stroke outcomes. pg/ml) as compared to cardioembolic (35.6±6.5 p<0.01).Conclusions:Our
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