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Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial

Cardiovascular Diabetology

Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.

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2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Circulation

METHODS:The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing.

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Ceramides aggravate atherosclerosis via G protein-coupled receptor signalling

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 March 2025; doi:10.1038/s41569-025-01149-8 A study published in Nature has identified two transmembrane G protein-coupled receptors that mediate extracellular-to-intracellular ceramide signalling and shows that blocking these receptors alleviates the atherosclerosis that is induced by a high-fat diet (..)

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Endothelin System in Hypertension and Chronic Kidney Disease

Hypertension Journal

ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc.

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Your Top Five Questions About CMHC On-Demand, Answered

Cardiometabolic Health Congress

Don’t worry—you can still access the 19th Annual CMHC sessions through our On-Demand platform, which offers 14 CME credits across four comprehensive tracks: Cardiorenal Health: Stay up-to-date with the latest on therapies for resistant hypertension, chronic kidney disease markers, and cardiac risk assessment tools.

CME 52
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How High Blood Pressure Affects Your Heart and What You Can Do About It

MIBHS

Secondary hypertension : This type results from an underlying condition such as kidney disease, hormonal disorders, or the use of certain medications. This condition, called atherosclerosis, narrows the arteries, restricting blood flow and increasing the risk of heart attacks and strokes.

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Targeting pharmacotherapies for inflammatory and cardiorenal endpoints in kidney disease

Journal of Cardiovascular Pharmacology

Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation.