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This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease. to 1.91), or hypertensive BP and high LVMI (RR 1.72, 95% CI 1.26
Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). However, the impact of preventative oral behavior such as dental flossing is unknown. The log WMH volume was higher (9.50.85
Atherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathwaya key innate immune signaling cascadein driving AS progression.
High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Often referred to as the silent killer, hypertension can quietly damage your heart and other vital organs over time. Hypertension is diagnosed when blood pressure consistently reads 130/80 mm Hg or higher.
In recent issues of the JCI, two independent papers highlight a direct role of endothelial LDs in the genesis of hypertension and atherosclerosis in rodent models. demonstrated that accumulation of LDs in the endothelium leads to hypertension, impairs endothelial function, and accelerates atherosclerosis.
Coronary angiography showed mild, non-obstructive atherosclerosis in the dominant left circumflex artery (LCx), which continued along the anatomical course of the RCA. Case 2 was a 79-year-old man with a history of hypertension and coronary heart disease who presented with gradually worsening fatigue lasting 6h.
Hypertension, Ahead of Print. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc.
Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. In addition, the role of the ratio of systolic and diastolic pressure (SDR) in the subclinical atherosclerosis (AS) risk remains unknown.
Hypertension, Ahead of Print. By now chronic renovascular disease (RVD) due to renal artery stenosis is recognized as a major source of renovascular hypertension and renal disease. Almost a hundred years have passed since obstruction of the renal artery has been recognized to raise blood pressure.
A 63 year old man with a history of hypertension, hyperlipidemia, prediabetes, and a family history of CAD developed chest pain, shortness of breath, and diaphoresis after consuming a large meal at noon. He called EMS, who arrived on scene about two hours after the onset of pain to find him hypertensive at 220 systolic.
Recently, indisputable evidence has shown that the TyG index is strongly associated with cardiovascular disease [CVD, including atherosclerosis, heart failure (HF), and hypertension] prognosis and mortality.
Background:The mechanisms by which intracranial atherosclerosis (ICAS) contributes to large-vessel occlusion strokes (LVOS) remains unclear. Among ICAS-LVOS patients, those with a greater thrombus burden showed associations with hypertension (OR: 6.071; P = 0.029) and higher fibrinogen levels (OR: 2.322; P = 0.046).
Background:Intracranial atherosclerosis (ICAS) is a common stroke cause, with a recurrent stroke risk of up to 18% per year despite treatment advances. Hypertension was present in 74% of the intervention group and 71% of controls. Stroke, Volume 56, Issue Suppl_1 , Page AWP292-AWP292, February 1, 2025. months (IQR 9.75-25.5).
Any atherosclerotic plaque is bad, and its presence portends a worse prognosis if modifiable risk factors like hypertension and smoking are not addressed.
The prevalence of HF risk factors was high: hypertension, 61.9%; former or current smoking, 53.7%; obesity 34.8%; diabetes; 24.7%; and chronic kidney disease; 22%. Results:Median age was 73 (25th–75th percentile 67–81) years, 53.2% were female, 25.6% were Black, 12.8% were Chinese, and 40.0% were White.
At the patient level, those with reduced CFR showed a significantly higher prevalence of diffused atherosclerosis (41% vs. 23%; P < 0.001) and higher FAI (−75.5 HU In the patient-level analysis, obstructive CAD, diffused atherosclerosis, and FAI were independently linked with CFR. Results We detected a decrease in CFR (<2.5)
Multiple metabolites of KP have been observed to exhibit elevated concentrations in plasma across various cardiovascular diseases, such as atherosclerosis, hypertension, and acute myocardial infarction. Multiple studies have indicated that kynurenine (KYN) may serve as a potential biomarker for several adverse cardiovascular events.
Don’t worry—you can still access the 19th Annual CMHC sessions through our On-Demand platform, which offers 14 CME credits across four comprehensive tracks: Cardiorenal Health: Stay up-to-date with the latest on therapies for resistant hypertension, chronic kidney disease markers, and cardiac risk assessment tools.
Innovations in Cardiorenal Metabolic Medicine The event will focus on the whole spectrum of cardiorenal metabolic disease, including obesity, diabetes, lipids, hypertension, and cardiorenal disease. Michos, MD, MHS, FACC, FAHA, FASE, FASPC ; famed hypertension expert Keith C.
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We found that a history of hypertension and diabetes are independent determinants of having a high-risk CAC score. This study involved a total of 1,129 female patients from a single centre.
Hypertension, Ahead of Print. Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. These pathways share a dependence upon redox signaling, and excessive activation promotes oxidative stress that promotes vascular aging.
Hypertension, Ahead of Print. BACKGROUND:In the absence of outcome-based ambulatory blood pressure (BP) data hypertension guidelines provide 24-hour mean BP values corresponding to trial-validated office BP values.
IntroductionThe incidence of metabolic disorders during pregnancy is increasing year by year, with diseases including hypertension and hyperlipidemia. Statins are the primary drugs for treating hyperlipidemia or atherosclerosis, yet some patients remain unresponsive to them, and pregnant women are prohibited from taking statins.
The presence of KLF4, another crucial member, suppresses the progression of atherosclerosis (AS) and pulmonary hypertension by attenuating the formation of VSMCs-derived foam cells, ameliorating endothelial dysfunction, and inducing vasodilatory effects.
The significance of RNA modification in the pathogenesis of hypertension, cardiac hypertrophy, and atherosclerosis is well-established. Cardiomyopathy, particularly DCM, often has genetic underpinnings, with established or suspected genetic origins. Up to 40% of DCM cases involve probable or confirmed genetic variations.
Hypertension, Ahead of Print. Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease.
Keynote speaker and atherosclerosis expert Peter Libby, MD , captivated the audience with an update on his research into inflammation and atherosclerosis. He discussed therapeutic options not only for treating atherosclerosis but also for preventing cardiovascular disease.
Hypertension, Ahead of Print. Dysregulation of β-arrestin signaling has been linked to several cardiovascular diseases including hypertension, atherosclerosis, and heart failure. β-arrestins are a family of intracellular signaling proteins that play a key role in regulating the activity of G protein-coupled receptors.
Urine output gradually returned after 3 weeks, and serum creatinine level was normalized after 2 months.ConclusionsTransplant recipients commonly have atherosclerosis and hypertension, which are risk factors for arterial dissection.
The cutoff value was 2.13, and in the hypertensive population, the cutoff value was 1.93.Conclusions:There Conclusions:There is an L-shaped association between NHHR levels and atherosclerosis in adults in the United States, and controlling NHHR is clinically important for reducing the risk of developing atherosclerosis.
Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. were women, 87% had hypertension, 48.1% IL-2Rα levels were significantly elevated in patients with ischemic stroke due to large-artery atherosclerosis (53.5±4.7 had hyperlipidemia.
While traditional vascular risk factors (eg, hypertension, dyslipidemia, tobacco use) account for 20% of the explained variance in carotid atherosclerosis, they remain a prominent focus for primary and secondary ischemic stroke prevention strategies. Stroke: Vascular and Interventional Neurology, Ahead of Print.
Hypertension, Ahead of Print. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms.
So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Atherosclerosis is not a worrisome issue as long as it is contained deep within the vessel wall and doesn’t encroach the lumen. A sudden shearing stress of intracoronary hypertensive spike can crack a 650 micron cap. Atherosclerosis.
While this response is adaptive in the short term, chronic stress keeps your blood pressure elevated for extended periods, increasing your risk of hypertension (high blood pressure) and its associated complications, such as heart disease and stroke.
Hypertension, Ahead of Print. BACKGROUND:Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dementia.
The patients were categorized into two groups according to the etiology of the ICA lesion: atherosclerosis and dissection. 467 (88.8%) patients presented with atherosclerosis of the ICA, and 59 (11.2%) patients presented dissection. IQR 44 ‐ 63], p< 001), rates of hypertension (74.5% IQR 61 ‐ 76] vs. 52 y. vs. 27.1%, p=.001),
There were no differences with rates of hypertension, hyperlipidemia, diabetes, smoking, heart failure, and pulmonary hypertension among MPN Veterans with stroke with and without AO exposure.In The biologic plausibility of endothelial dysfunction and accelerated atherosclerosis from AO exposure warrants further investigation.
White matter hyperintensities (WMH) and cerebral microbleeds (CMB) are manifestations of CSVD.Methods:Using the Atherosclerosis Risk in Communities (ARIC) database, we extracted data from 1112 participants assessed for dental caries and vascular risk factors. Of those, 203 (18.3%) had caries and 909 (81.7%) did not. OR 1.52 (95% 0.96
The expanded risk score includes vascular risk factors, migraine characteristics, and medications used in migraine patients.Methods:We prospectively evaluated participants in Atherosclerosis Risk in Communities Cohort (ARIC) with history of migraine.
A 69‐year‐old woman with a history of lung cancer, hypertension, chronic tobacco use, atherosclerosis, and known calcified plaque at the left carotid bifurcation on dual antiplatelet therapy presented with acute onset of expressive aphasia and right hemiparesis due to acute left CCAO.
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