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While advances in treatment have reduced mortality in some regions, the atherosclerosis prevention remains challenging. This shift results from an epidemiologic transition: as infectious diseases decline, chronic conditions like atherosclerosis dominate.
This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease. to 1.91), or hypertensive BP and high LVMI (RR 1.72, 95% CI 1.26
The BACKBEAT pivotal study will evaluate the efficacy and safety of atrioventricular interval modulation (“AVIM”) therapy (also known as BackBeat CNT), for the treatment of pacemaker-indicated patients with uncontrolled hypertension despite the use of antihypertensive medications. Orchestra BioMed and Medtronic, Inc. Kowal, M.D., and Europe.
Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). However, the impact of preventative oral behavior such as dental flossing is unknown. The log WMH volume was higher (9.50.85
High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Often referred to as the silent killer, hypertension can quietly damage your heart and other vital organs over time. Hypertension is diagnosed when blood pressure consistently reads 130/80 mm Hg or higher.
The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Shapiro (United States of America) focused on preventing atherosclerosis over myocardial infarction, suggesting that CAC’s late-stage detection does not fit classic definitions of primary prevention.
Hypertension, Ahead of Print. BACKGROUND:Orthostatic hypertension is an emerging risk factor for adverse events. These differences in CVD risk raise important concerns about combining systolic orthostatic increases and standing SBP 140 mm Hg in a consensus definition for orthostatic hypertension.
Coronary angiography showed mild, non-obstructive atherosclerosis in the dominant left circumflex artery (LCx), which continued along the anatomical course of the RCA. Case 2 was a 79-year-old man with a history of hypertension and coronary heart disease who presented with gradually worsening fatigue lasting 6h.
In recent issues of the JCI, two independent papers highlight a direct role of endothelial LDs in the genesis of hypertension and atherosclerosis in rodent models. demonstrated that accumulation of LDs in the endothelium leads to hypertension, impairs endothelial function, and accelerates atherosclerosis.
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4
Hypertension, Ahead of Print. ETs were shown to play important roles among others, in systemic hypertension, particularly when resistant or difficult to control, and in pulmonary hypertension, atherosclerosis, cardiac hypertrophy, subarachnoid hemorrhage, chronic kidney disease, diabetic cardiovascular disease, scleroderma, some cancers, etc.
Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined. In addition, the role of the ratio of systolic and diastolic pressure (SDR) in the subclinical atherosclerosis (AS) risk remains unknown.
Hypertension, Ahead of Print. By now chronic renovascular disease (RVD) due to renal artery stenosis is recognized as a major source of renovascular hypertension and renal disease. Almost a hundred years have passed since obstruction of the renal artery has been recognized to raise blood pressure.
A 63 year old man with a history of hypertension, hyperlipidemia, prediabetes, and a family history of CAD developed chest pain, shortness of breath, and diaphoresis after consuming a large meal at noon. He called EMS, who arrived on scene about two hours after the onset of pain to find him hypertensive at 220 systolic.
Carotid atherosclerosis (CAS) is a critical precursor to atherosclerotic cardiovascular disease and is closely associated with the development and progression of conditions such as stroke and poor prognosis. Stroke, Volume 56, Issue Suppl_1 , Page ATP288-ATP288, February 1, 2025. 2021-KY-1289-001).Results:Among respectively.
Recently, indisputable evidence has shown that the TyG index is strongly associated with cardiovascular disease [CVD, including atherosclerosis, heart failure (HF), and hypertension] prognosis and mortality.
(Arteriosclerosis, Thrombosis and Vascular Biology) A role for hemoglobin in atherosclerosis is supported by a study that used serial coronary CT angiography to demonstrate an association between persistently low serum hemoglobin levels and greater changes in coronary plaque volume.
Excess salt in the diet was indicated as a recognized risk factor in the case of hypertension 82.4%, atrial fibrillation 28.8%, obesity 36.4%, type 2 diabetes 20.4%, lipid disorders 18.5%, heart failure 59.1%, stroke 56.9%, and atherosclerosis 42.2%. to even 53%.
Background:The mechanisms by which intracranial atherosclerosis (ICAS) contributes to large-vessel occlusion strokes (LVOS) remains unclear. Among ICAS-LVOS patients, those with a greater thrombus burden showed associations with hypertension (OR: 6.071; P = 0.029) and higher fibrinogen levels (OR: 2.322; P = 0.046).
Background:Intracranial atherosclerosis (ICAS) is a common stroke cause, with a recurrent stroke risk of up to 18% per year despite treatment advances. Hypertension was present in 74% of the intervention group and 71% of controls. Stroke, Volume 56, Issue Suppl_1 , Page AWP292-AWP292, February 1, 2025. months (IQR 9.75-25.5).
Any atherosclerotic plaque is bad, and its presence portends a worse prognosis if modifiable risk factors like hypertension and smoking are not addressed.
The prevalence of HF risk factors was high: hypertension, 61.9%; former or current smoking, 53.7%; obesity 34.8%; diabetes; 24.7%; and chronic kidney disease; 22%. Results:Median age was 73 (25th–75th percentile 67–81) years, 53.2% were female, 25.6% were Black, 12.8% were Chinese, and 40.0% were White.
At the patient level, those with reduced CFR showed a significantly higher prevalence of diffused atherosclerosis (41% vs. 23%; P < 0.001) and higher FAI (−75.5 HU In the patient-level analysis, obstructive CAD, diffused atherosclerosis, and FAI were independently linked with CFR. Results We detected a decrease in CFR (<2.5)
Don’t worry—you can still access the 19th Annual CMHC sessions through our On-Demand platform, which offers 14 CME credits across four comprehensive tracks: Cardiorenal Health: Stay up-to-date with the latest on therapies for resistant hypertension, chronic kidney disease markers, and cardiac risk assessment tools.
Multiple metabolites of KP have been observed to exhibit elevated concentrations in plasma across various cardiovascular diseases, such as atherosclerosis, hypertension, and acute myocardial infarction. Multiple studies have indicated that kynurenine (KYN) may serve as a potential biomarker for several adverse cardiovascular events.
Innovations in Cardiorenal Metabolic Medicine The event will focus on the whole spectrum of cardiorenal metabolic disease, including obesity, diabetes, lipids, hypertension, and cardiorenal disease. Michos, MD, MHS, FACC, FAHA, FASE, FASPC ; famed hypertension expert Keith C.
Inflammation: Genetic variations can make some people more prone to chronic inflammation, which contributes to the development of atherosclerosis. Maintain a Healthy Weight: Obesity amplifies the effects of genetic predispositions by contributing to high cholesterol, hypertension, and diabetes.
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We found that a history of hypertension and diabetes are independent determinants of having a high-risk CAC score. This study involved a total of 1,129 female patients from a single centre.
Hypertension, Ahead of Print. Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. These pathways share a dependence upon redox signaling, and excessive activation promotes oxidative stress that promotes vascular aging.
Hypertension, Ahead of Print. BACKGROUND:In the absence of outcome-based ambulatory blood pressure (BP) data hypertension guidelines provide 24-hour mean BP values corresponding to trial-validated office BP values.
IntroductionThe incidence of metabolic disorders during pregnancy is increasing year by year, with diseases including hypertension and hyperlipidemia. Statins are the primary drugs for treating hyperlipidemia or atherosclerosis, yet some patients remain unresponsive to them, and pregnant women are prohibited from taking statins.
The presence of KLF4, another crucial member, suppresses the progression of atherosclerosis (AS) and pulmonary hypertension by attenuating the formation of VSMCs-derived foam cells, ameliorating endothelial dysfunction, and inducing vasodilatory effects.
Hypertension, Ahead of Print. Aortic diseases such as atherosclerosis, aortic aneurysms, and aortic stiffening are significant complications that can have significant impact on end-stage cardiovascular disease.
Keynote speaker and atherosclerosis expert Peter Libby, MD , captivated the audience with an update on his research into inflammation and atherosclerosis. He discussed therapeutic options not only for treating atherosclerosis but also for preventing cardiovascular disease.
Urine output gradually returned after 3 weeks, and serum creatinine level was normalized after 2 months.ConclusionsTransplant recipients commonly have atherosclerosis and hypertension, which are risk factors for arterial dissection.
Hypertension, Ahead of Print. Dysregulation of β-arrestin signaling has been linked to several cardiovascular diseases including hypertension, atherosclerosis, and heart failure. β-arrestins are a family of intracellular signaling proteins that play a key role in regulating the activity of G protein-coupled receptors.
The cutoff value was 2.13, and in the hypertensive population, the cutoff value was 1.93.Conclusions:There Conclusions:There is an L-shaped association between NHHR levels and atherosclerosis in adults in the United States, and controlling NHHR is clinically important for reducing the risk of developing atherosclerosis.
Background:Ischemic stroke can arise from various etiologies, such as cardioembolism, atherosclerosis, small vessel disease or cryptogenic. were women, 87% had hypertension, 48.1% IL-2Rα levels were significantly elevated in patients with ischemic stroke due to large-artery atherosclerosis (53.5±4.7 had hyperlipidemia.
While traditional vascular risk factors (eg, hypertension, dyslipidemia, tobacco use) account for 20% of the explained variance in carotid atherosclerosis, they remain a prominent focus for primary and secondary ischemic stroke prevention strategies. Stroke: Vascular and Interventional Neurology, Ahead of Print.
Hypertension, Ahead of Print. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms.
So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Atherosclerosis is not a worrisome issue as long as it is contained deep within the vessel wall and doesn’t encroach the lumen. A sudden shearing stress of intracoronary hypertensive spike can crack a 650 micron cap. Atherosclerosis.
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