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It has been mentioned that risk due to clonal hematopoiesis is equal in magnitude to conventional risk factors like smoking, hypertension, dyslipidemia and diabetes. They conducted deep sequencing of selected genomic regions in 968 patients with asymptomatic carotid atherosclerosis detected by duplex sonography.
There was no increase in new onset diabetes mellitus or worsening of diabetes mellitus. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Treatment discontinuation was similar to placebo. at 6 months compared to placebo. Nat Commun. 2016 Nov 28;7:13457.
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