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Nature Reviews Cardiology, Published online: 13 January 2025; doi:10.1038/s41569-024-01115-w In this Review, Khan and Jandeleit-Dahm discuss pathological mechanisms involved in atherosclerosis development and progression in patients with diabetes mellitus and highlight novel therapeutic targets to treat atherosclerosis in these patients.
Preeclampsia (PE) and type 1 diabetes (T1D) are significant risk factors for cardiovascular disease (CVD), but their combined effect on atherosclerosis progression has not been fully explored. This study aimed.
Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.
Lower extremity peripheral artery disease (PAD) often results from atherosclerosis, and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Individuals with T2DM exhibit a more severe manifes.
Since the arrival of continuous glucose monitoring (CGM), the relationship between the glucose management indicator (GMI) and HbA1c has been a topic of considerable interest in diabetes research. This study ai.
Diabetes mellitus (DM) is thought to be closely related to arterial stenotic or occlusive disease caused by atherosclerosis. However, there is still no definitive clinical evidence to confirm that patients wit.
However, their utility in treating diabetes-associated ather. Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies.
Atherosclerotic cardiovascular diseases remain the leading cause of mortality in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of atherosclerosis, which is exacerbate.
This study examines the relationship between tHcy, HF overall, and HF subtype (HF with preserved ejection fraction [HFpEF] and HF with reduced ejection fraction) in the MultiEthnic Study of Atherosclerosis cohort.MethodsMultiEthnic Study of Atherosclerosis participants with baseline tHcy and HF data were included (N=6765).
Diabetes-induced trained immunity contributes to the development of atherosclerosis and its complications. This study aimed to investigate in humans whether epigenetic signals involved in immune cell activatio.
Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). However, the impact of preventative oral behavior such as dental flossing is unknown. The log WMH volume was higher (9.50.85
Abstract: Worldwide, type 2 diabetes is predominant form of diabetes, and it is mainly affected by the environment. In the process of diabetes onset and intergenerational transmission, the genetic structure of the individual is not directly changed but is regulated by epigenetics.
Diabetic panvascular disease (DPD) is the leading clinical complication of diabetes mellitus (DM), characterized by atherosclerosis across multiple organ vessels. It is a major cause of high disability and mor.
Recent studies implicate EndMT in atherosclerosis development. Diabetes is associated with both EndMT as well as accelerated atherosclerosis. Experimental evidence supports the use of epigenetic drugs that act on relevant epigenetic mechanisms to attenuate atherosclerosis. RNA sequencing was performed in this setting.
Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.
Type 2 diabetes mellitus (T2DM) is a highly prevalent risk factor that likely contributes to this disparity. The risk of atherosclerotic cardiovascular disease (ASCVD) is approximately twofold higher for South Asian (SA) adults than for adults from other racial and ethnic groups.
Individuals with type 1 diabetes are at increased risk of accelerated atherosclerosis, causing coronary artery disease (CAD). The underlying mechanisms remain unclear, but new theories proposed are damage of g.
Besides other problems like diabetes and atherosclerosis, saturated fats have also been linked to life-threatening arrhythmias. Over the past few decades, scientists have generated a pile of evidence suggesting that a diet rich in saturated fats is enough to cause heart diseases.
Methods We retrospectively analysed data from 5188 participants in the Atherosclerosis Risk in Communities Study who were free from heart failure at baseline, including 802 individuals with a history of myocardial infarction. Patients with pulse pressure ≥68 mm Hg had a 3.83-fold m/s had a 2.10-fold
ApoB Atherosclerosis, by definition, is caused by the retention of an ApoB lipid particle in the artery wall. This retained particle then sets off an inflammatory cascade, which ultimately results in the formation of atherosclerosis 1. Mechanism of atherosclerosis formation. Relationship of BMI and Risk Of Diabetes.
Both insulin resistance and hyperglycemia are important risk factors for atherosclerosis. While the characteristics of atherosclerosis are obviously different according to established diabetes, little has been.
Gestational diabetes is a common medical complication of pregnancy that is associated with adverse perinatal outcomes and an increased risk of metabolic diseases and atherosclerosis in adult offspring. The mechanisms responsible for this delayed pathological transmission remain unknown.
BACKGROUND:Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Circulation: Genomic and Precision Medicine, Ahead of Print.
Atherogenic index of plasma (AIP) is a non-traditional lipid parameter that can reflect the burden of atherosclerosis. A lipid profile resembling atherosclerosis emerged during pregnancy. Although lipid metabo.
The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.
Elevated RLP-C levels were associated with high triglyceride concentrations, diabetes mellitus, and increased risk of revascularization.ConclusionsThis study illustrated the atherogenic impact of RLP-C in CAD patients. High RLP-C levels increased the risk of revascularization.
Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. Aims Abnormalities in specific echocardiographic parameters and cardiac biomarkers have been reported among individuals with diabetes. Participants with (vs.
Multivariable logistic regression showed that patients with largeartery atherosclerosis pathogenesis, diabetes, higher admission National Institutes of Health Stroke Scale scores, and higher 90day modified Rankin Scale had significantly lower odds of RTW.
The prevalence of HF risk factors was high: hypertension, 61.9%; former or current smoking, 53.7%; obesity 34.8%; diabetes; 24.7%; and chronic kidney disease; 22%. Results:Median age was 73 (25th–75th percentile 67–81) years, 53.2% were female, 25.6% were Black, 12.8% were Chinese, and 40.0% were White.
The CAD Staging System is a noninvasive imaging-based investigational software device that analyzes important and actionable features of coronary atherosclerosis, stenosis and ischemia. Food and Drug Administration ( FDA ) for its Coronary Artery Disease ( CAD ) Staging System.
At the patient level, those with reduced CFR showed a significantly higher prevalence of diffused atherosclerosis (41% vs. 23%; P < 0.001) and higher FAI (−75.5 HU In the patient-level analysis, obstructive CAD, diffused atherosclerosis, and FAI were independently linked with CFR. Results We detected a decrease in CFR (<2.5)
Diabetes Management: Gain insights into precision medicine, advanced insulin therapies, and continuous glucose monitoring (CGM) for cardiovascular risk assessment. Dyslipidemia, Atherosclerosis & Thrombosis: Explore non-statin therapies, strategies for managing hypertriglyceridemia, and new guidance on lipoprotein(a) management.
Practical, Future-Focused Education Cardiorenal and metabolic diseases, fueled by poor lifestyle choices and health conditions, lead to type 2 diabetes, cardiovascular disease, and chronic kidney disease. The robust conference agenda begins with FDA updates and advancements in cardiorenal metabolic care.
cobalt, copper, zinc) are associated with increased coronary artery calcification (CAC) and are comparable to traditional cardiovascular disease risk factors like smoking and diabetes, according to results from the Multi-Ethnic Study of Atherosclerosis (MESA) published in JACC. Urinary levels of non-essential (i.e.,
Coronary heart disease is a narrowing or obstruction of the vascular cavity caused by atherosclerosis of the coronary arteries, which leads to myocardial ischemia and hypoxia. Sodium-glucose cotransporter 2 (SGLT2) inhibitor is a new oral glucose-lowering agent used in the treatment of diabetes in recent years.
Background:The association between left ventricular injury (LVI) detected by cardiac magnetic resonance imaging (CMR) and the risk of a subsequent ischemic stroke is unknown.Methods:We studied stroke-free participants in the Multi-Ethnic Study of Atherosclerosis study who underwent a steady-state free precession CMR at Exam 5 (2010-2012).
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We found that a history of hypertension and diabetes are independent determinants of having a high-risk CAC score. This study involved a total of 1,129 female patients from a single centre.
However, due to the distinct biological functions of ASCs from different origins or donors with varing health statuses (such as aging, diabetes, or atherosclerosis), the heterogeneity of ASCs deserves more attention. Exosomes from ASCs also play an indispensable role in this process.
This happens more commonly in people with metabolic risk factors such as obesity, diabetes, or high triglycerides. guidelines may overlook people who are at higher risk of developing atherosclerosis despite normal metabolic health markers. But even people without these conditions can have discordance. population.
BackgroundPlaque progression (PP) is critical between subclinical atherosclerosis and plaque rupture. P=0.006), especially in diabetic patients (Pearsonr=0.58,P<0.001). Journal of the American Heart Association, Ahead of Print. months, PP was found in 65 lesions (44.5%), and mean changes in percent atheroma volume were 4.1%10.2%.
The fundamental role of qualitative alterations of lipoproteins in the early development of atherosclerosis has been widely demonstrated. However, the corresponding studies are scarcer in the field of ischemic stroke, despite carotid arteriosclerosis progression underlies at least 20% of ischemic strokes.
Keynote speaker and atherosclerosis expert Peter Libby, MD , captivated the audience with an update on his research into inflammation and atherosclerosis. He discussed therapeutic options not only for treating atherosclerosis but also for preventing cardiovascular disease.
The focus will be on the intricate interplay between cardiorenal and metabolic conditions, such as type 2 diabetes, cardiovascular disease, and chronic kidney disease, driven by lifestyle and health factors. Aronne, MD Expert Perspectives on Initiating and Maintaining Insulin Therapy in Type 2 Diabetes Patients Jay H.
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