Coronary Artery Disease Journal

DECEMBER 1, 2024

Background Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease due to its unique apo(a) component and its association with atherosclerosis and thrombogenesis. to 1.20), total cholesterol, triglycerides, and Lp(a) levels while increasing high-density lipoprotein cholesterol levels.

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GEMMS

NOVEMBER 22, 2023

Good cardiovascular health is essential for maintaining a healthy lifestyle and reducing the risk of heart disease, stroke, and other cardiovascular conditions. Maintaining cardiovascular health reduces the risk of developing various heart diseases, including heart attack, stroke, and high blood pressure.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. A therapy that has been proven repeatedly to reduce the probability of heart attacks and strokes in multiple double-blind randomised controlled studies 1. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

MIBHS

AUGUST 15, 2024

Blood Vessels: Chronic stress can impair the function of the endothelium—the lining of blood vessels—potentially leading to atherosclerosis, a precursor to heart disease. Lipid Metabolism: Chronic stress can alter lipid metabolism, potentially increasing bad cholesterol (LDL) and decreasing good cholesterol (HDL).

Blood Pressure 52

Blood Pressure Cholesterol Heart Disease Diet 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP318-ATP318, February 1, 2025. Introduction:Elevated Low-Density-Lipoprotein Cholesterol (LDL-C) blood levels are a risk factor for atherosclerosis. Lipid-lowering therapies mitigate the risk of atherothrombotic events.

Stenosis 40

Stenosis Atherosclerosis Cholesterol Ischemia 40

Dr. Paddy Barrett

FEBRUARY 14, 2025

“Cholesterol does not cause heart disease.“ “Cholesterol doesn’t cause heart disease” The argument goes like this. “If cholesterol causes heart disease, why is it that about half of all patients with a heart attack have normal cholesterol? Cholesterol is an essential part of the story.

Cholesterol 114

Cholesterol Heart Disease Heart Attack Heart attacks 114

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP226-ATP226, February 1, 2024. Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ADP14-ADP14, February 1, 2025. Background:PCSK9, a key regulator of cholesterol metabolism, has been implicated in atherosclerosis. However, its potential role in vascular cognitive impairment and dementia (VCID) remains elusive.

Diet 40

Diet Dementia Atherosclerosis Cholesterol 40

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries. How Do Genetic Factors Work?

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

DAIC

MARCH 31, 2025

The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 These new data reinforce the use of LODOCO(colchicine, 0.5

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

DAIC

FEBRUARY 1, 2024

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Stroke Strokes 104

DAIC

JANUARY 23, 2024

3 Patients with ASCVD are at a higher risk for major adverse cardiovascular events (MACE) including heart attack or myocardial infarction (MI), stroke, and cardiovascular (CV) death.4 1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. 4 In the U.S.

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP388-AWP388, February 1, 2025. Incident stroke (ischemic and hemorrhagic) was ascertained until the end of 2021 with adjudication by an expert panel. Cox regression was used to estimate the hazard ratio (HR) for incident stroke per doubling of EIC levels, and p-values were FDR corrected.

Atherosclerosis 40

Atherosclerosis Strokes Stroke Atrial Fibrillation 40

Dr. Sanjay Gupta

DECEMBER 19, 2022

Today’s video is on the subject of stroke and in particular cryptogenic strokes. It is therefore crucial to identify the cause of stroke and treat the underlying cause wherever possible. Strokes are characterised by death of brain cells as a result of disruption of blood supply to those cells.

Stroke 52

Stroke Strokes Blood Clot AFIB 52

Dr. Paddy Barrett

OCTOBER 4, 2024

Controlling LDL cholesterol. Let's take a 42-year-old male with an LDL cholesterol of 5.1 How much would they benefit from going on a cholesterol lowering medication? Now add in an elevated Lp(a), which is a common genetic cholesterol particle disorder, and that risk reduction gets even bigger. Being active. Not smoking.

Heart Disease 105

Heart Disease Plaque Cholesterol Risk Factors 105

DAIC

JANUARY 30, 2024

Clinicians currently use two separate risk models to assess patients’ chances of having heart attacks , strokes , and other major cardiovascular events. Using a dataset from a different study, the Multi-Ethnic Study of Atherosclerosis , the team validated the accuracy of their model and overall findings.

Cardiovascular Disease 52

Cardiovascular Disease Research Heart Attack Heart attacks 52

DAIC

MAY 16, 2024

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. There were no significant effects on fatal or nonfatal stroke, death from cardiovascular causes and death from any cause. Nat Commun. 2016 Nov 28;7:13457.

Cholesterol 52

Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

DAIC

MARCH 31, 2025

The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 These new data reinforce the use of LODOCO(colchicine, 0.5

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

Heart 2023 Conference

APRIL 20, 2022

(Naturopathic Medicine) According to a subanalysis of a randomised study, low-dose edoxaban (Savaysa) was related with a reduced stroke risk and a negligible increase in bleeding in older Afib patients at high bleeding risk.

Pulmonary 52

Pulmonary Hypertension AFIB COVID-19 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP239-AWP239, February 1, 2024. Introduction:Apolipoprotein E4 (ApoE4) allele is linked to increased LDL-Cholesterol, one of the main risk factors for intracranial large artery stenosis (ICAS). Whether these interactions influence the risk of stroke and dementia should be further investigated.

Stenosis 40

Stenosis Risk Factors Hypertension Dementia 40

Dr. Paddy Barrett

AUGUST 1, 2023

A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. First off, CTCA is a noninvasive test, and many patients with chest pain would previously have needed invasive angiography with all the risks it entails, including heart attack, stroke and death (albeit very rare). And it matters.

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 269-277, February 1, 2024. BACKGROUND:Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques.

Plaque 40

Plaque Circulation Atherosclerosis Hemorrhage 40

Dr. Paddy Barrett

JULY 12, 2024

If you have high LDL cholesterol and are unsure what that means for your risk of heart disease, this article is for you. Over the course of your lifetime, your LDL cholesterol will slowly increase. By midlife, the average male and female will see a significant rise in their LDL cholesterol. to 4 mmol (135 to 155 mg/dl).

Cholesterol 106

Cholesterol Heart Attack Heart attacks Blood Pressure 106

Dr. Paddy Barrett

OCTOBER 10, 2023

Lipoprotein (a) Approximately 1 in 5 people have the Lp(a) variant of cholesterol particle that significantly increases the risk of early heart disease and stroke. Blood Pressure Control For every 20 mmHg increase in systolic blood pressure, the risk of dying from heart attack or stroke doubles 3. J Am Coll Cardiol.

Risk Factors 52

Risk Factors Heart Disease Blood Pressure Coronary Artery Disease 52

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies​. The trial highlights the importance of reevaluating and optimizing thrombolytic therapies for better patient outcomes.

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59