Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

Risk Factors 111

Risk Factors Heart Disease Heart attacks Heart Attack 111

Dr. S. Venkatesan MD

OCTOBER 2, 2024

Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? I recently read in Forbes Sunday health supplement, It says ,it is better to know the thickness of the cap covering the plaque. So, you want me to teach you the molecular biology of Atherosclerosis ,right ? Korean Circ J.

Plaque 52

Plaque Atherosclerosis Education Cholesterol 52

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 105

Coronary Artery Disease Plaque Exercise Heart attacks 105

Cardiovascular Diabetology

JULY 3, 2024

The abnormal low-density protein cholesterol (LDL-C) level in the development of atherosclerosis is often comorbid in individuals with type 2 diabetes mellitus(T2DM). This study aimed to investigate the aggrav.

Cholesterol 45

Cholesterol Diabetes Atherosclerosis Plaque 45

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Circulation

NOVEMBER 11, 2024

Introduction:It remains uncertain whether dietary supplementation of marine n-3 polyunsaturated fatty acids (PUFAs) improves atherosclerosis and lipoprotein subclasses in patients with type 2 diabetes (T2D). The primary outcome was the prevalence of carotid artery plaques assessed by ultrasound. day) or low-dose (1.5g/day)

Atherosclerosis 40

Atherosclerosis Diabetes Plaque Cholesterol 40

Circulation

NOVEMBER 11, 2024

CCR5, a chemokine receptor, has been associated with both immunosuppressive and inflammatory phenotypes, however, the possible role of CCR5 pertaining to MDSCs in the development of atherosclerosis has not been elucidated yet. Possibly this dysfunctionality contributes to the development and progression of CVD including atherosclerosis.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

CTVS

SEPTEMBER 17, 2024

PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source

Peripheral Arterial Disease 52

Peripheral Arterial Disease Plaque Atherosclerosis Cholesterol 52

AMS Cardiology

JANUARY 21, 2023

We all want to be heart-healthy and ensuring our cholesterol levels are in the normal range is one of the most critical steps. High cholesterol can increase your risk of severe conditions like heart disease and heart attacks. Continue reading to learn four heart-healthy habits that can improve your cholesterol.

Cholesterol 40

Cholesterol Diet Blood Pressure Heart attacks 40

Dr. S. Venkatesan MD

OCTOBER 7, 2024

The enlightened thinking is, if LDL and HDL are brought around the same level of around 50mg , good and evil will have level playing ground , hoping goodness will win over the evil.Our vast vascular tree will have perfect lipid house keeping system and atherosclerosis will cease to occur.( Final message.

Cholesterol 40

Cholesterol Plaque Atherosclerosis Circulation 40

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. Carotid ultrasound results were divided into two groups based on the presence or absence of plaque. Carotid plaque was observed in 1140 (43.5%) subjects and CACS>0 in 1172 (44.7%) subjects.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Heart 2023 Conference

MARCH 17, 2023

Atherosclerosis, also called " hardening of the arteries, " occurs when fat, cholesterol and other substances are deposited in the walls of the arteries. These deposits are called plaques. Over time, these plaques can narrow or completely block arteries and cause problems throughout the body.

Atherosclerosis 52

Atherosclerosis Exercise Plaque Cholesterol 52

Medical Xpress - Cardiology

FEBRUARY 26, 2025

Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.

Coronary Artery Disease 40

Coronary Artery Disease Heart Disease Plaque Atherosclerosis 40

Stroke Journal

NOVEMBER 9, 2023

This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease. Indirect data support such an approach in man.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

GEMMS

NOVEMBER 22, 2023

Factors such as smoking, high blood pressure, high cholesterol levels, obesity, and a sedentary lifestyle significantly increase the risk of developing cardiovascular disease. This process, known as atherosclerosis, increases the risk of heart disease, heart attacks, and strokes.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Dr. Paddy Barrett

FEBRUARY 14, 2025

“Cholesterol does not cause heart disease.“ “Cholesterol doesn’t cause heart disease” The argument goes like this. “If cholesterol causes heart disease, why is it that about half of all patients with a heart attack have normal cholesterol? Cholesterol is an essential part of the story.

Cholesterol 114

Cholesterol Heart Disease Heart attacks Heart Attack 114

Cardiometabolic Health Congress

JANUARY 15, 2025

While advances in treatment have reduced mortality in some regions, the atherosclerosis prevention remains challenging. This shift results from an epidemiologic transition: as infectious diseases decline, chronic conditions like atherosclerosis dominate.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

DAIC

MARCH 31, 2025

The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 mg on atherosclerotic plaque. Budoff, M.D.,

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

MIBHS

FEBRUARY 28, 2025

Genes influence various biological processes, including cholesterol metabolism, blood pressure regulation, and the strength and structure of your heart and blood vessels. Specific genetic variants, such as those affecting cholesterol metabolism, can increase the likelihood of plaque buildup in the arteries.

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Dr. Paddy Barrett

SEPTEMBER 20, 2024

When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. No atherosclerosis.

Heart Disease 111

Heart Disease Cholesterol Atherosclerosis Heart attacks 111

Frontiers in Cardiovascular Medicine

FEBRUARY 16, 2024

Introduction Atherosclerosis is a chronic inflammatory disease caused by the deposition of lipids within the artery wall. During atherogenesis, efficient autophagy is needed to facilitate efferocytosis and cholesterol efflux, limit inflammation and lipid droplet buildup, and eliminate defective mitochondria and protein aggregates.

Atherosclerosis 64

Atherosclerosis Plaque Diet Cholesterol 64

Dr. Paddy Barrett

OCTOBER 4, 2024

Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.

Heart Disease 105

Heart Disease Plaque Cholesterol Risk Factors 105

Physiologically Speaking

FEBRUARY 23, 2024

Specifically, eating a meal containing 25 grams of protein or more activates the mammalian target of rapamycin complex 1 (mTORC1) and inhibits autophagy in immune cells known as macrophages, which promote the buildup of plaque and cholesterol in arteries, a process known as atherosclerosis. Wordplay is not my forte).

Physiology 111

Physiology Atherosclerosis Diet Cardiovascular Disease 111

DAIC

MARCH 31, 2025

The study, Effect of Colchicine on Progression of Known Coronary Atherosclerosis in Patients With Stable Coronary Artery Disease Compared To Placebo: The Ekstrom Trial, was presented at the American College of Cardiology 74th Annual Scientific Session and Expo ( ACC.25 mg on atherosclerotic plaque. Budoff, M.D.,

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

Dr. Paddy Barrett

JANUARY 23, 2024

However, most adults will start to develop advanced plaque in their coronary arteries early in life. By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque.

Heart Disease 105

Heart Disease Blood Pressure Dementia Atherosclerosis 105

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. 4 In the U.S.

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Stroke Journal

JANUARY 21, 2024

BACKGROUND:Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques. Plaque stability was determined by gold-standard histological classifications. Adipokine, lipid, and immune profiling was conducted.

Plaque 40

Plaque Circulation Atherosclerosis Hemorrhage 40

Dr. Paddy Barrett

AUGUST 1, 2023

A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. A CT CAC scan of 0 indicates no significant amount of calcified atherosclerosis.

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

DAIC

MAY 16, 2024

PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. This plaque narrows the blood vessels and reduces blood flow to the legs and feet, which may significantly impair physical function, walking performance and quality of life.

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Heart 2023 Conference

APRIL 20, 2022

In patients who are not taking statins, Esperion announced that bempedoic acid with or without ezetimibe (Nexletol/Nexlizet) can lower LDL cholesterol by more than 25%. JACC: Asia) Lexaria Bioscience has announced that a CBD product beats a placebo in simulating acute pulmonary hypertension.

Pulmonary 52

Pulmonary Hypertension AFIB COVID-19 52

Wellnest

DECEMBER 21, 2022

Coronary artery disease Excessive cholesterol builds up plaque that blocks the arteries supplying blood to the heart. This condition is also called atherosclerosis. An ECG machine is able to detect other abnormalities of the heart as well, such as hypertrophic cardiomyopathy or overly thick heart muscles.

Cardiac Arrest 52

Cardiac Arrest Heart attacks Heart Attack Chest Pain 52

Dr. Paddy Barrett

JULY 12, 2024

If you have high LDL cholesterol and are unsure what that means for your risk of heart disease, this article is for you. Over the course of your lifetime, your LDL cholesterol will slowly increase. By midlife, the average male and female will see a significant rise in their LDL cholesterol. to 4 mmol (135 to 155 mg/dl).

Cholesterol 105

Cholesterol Heart attacks Heart Attack Blood Pressure 105

Dr. Paddy Barrett

MAY 31, 2024

Heart disease, the build-up of plaque in the coronary arteries, typically starts years, if not decades, prior to an event. These noninvasive scans look directly at the coronary arteries rather than assessing for the risk factors for coronary artery disease eg LDL cholesterol, high blood pressure etc. As the line goes, “No Plaque.

Heart Disease 97

Heart Disease Plaque Heart attacks Heart Attack 97

Dr. S. Venkatesan MD

JANUARY 8, 2024

10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. LDL is obviously a target against atherosclerosis. Chasing LDL cholesterol to the bottom — PCSK9 in perspective. Preamble 15 % of body weight is fat. Mind you LDL constitutes.000025%

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies​.

Blood Pressure 59

Blood Pressure Obesity Coronary Artery Disease Preserved Ejection Fraction 59