Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

This interaction led to increased cytosolic cholesterol in macrophages and changes in expression of lipid metabolism genes consistent with increased cholesterol uptake. This function of LDL uptake is unique to cathelicidins from humans and some primates and was not observed with cathelicidins from mice or rabbits.

Atherosclerosis 122

Atherosclerosis Cholesterol Cardiovascular Disease Plaque 122

Dr. Paddy Barrett

SEPTEMBER 20, 2024

When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1. No atherosclerosis.

Heart Disease 101

Heart Disease Cholesterol Atherosclerosis Heart attacks 101

Dr. S. Venkatesan MD

OCTOBER 7, 2024

The enlightened thinking is, if LDL and HDL are brought around the same level of around 50mg , good and evil will have level playing ground , hoping goodness will win over the evil.Our vast vascular tree will have perfect lipid house keeping system and atherosclerosis will cease to occur.( Final message.

Cholesterol 40

Cholesterol Atherosclerosis Plaque Circulation 40

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors. For cardiovascular disease, only low-density lipoprotein cholesterol and blood pressure are approved as surrogates for cardiovascular disease.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

CTVS

SEPTEMBER 17, 2024

PAD is a serious condition affecting circulation and blood vessels, causing them to narrow from plaque buildup in the arteries and blocking blood flow to the extremities, typically the legs and feet. It is triggered by atherosclerosis, which occurs when fatty deposits or cholesterol accumulates… Source

Peripheral Arterial Disease 52

Peripheral Arterial Disease Atherosclerosis Plaque Cholesterol 52

Stroke Journal

FEBRUARY 1, 2024

Background:Lipoprotein a (Lp(a)) is known to be associated with coronary artery disease and carotid artery atherosclerosis. Carotid ultrasound results were divided into two groups based on the presence or absence of plaque. Carotid plaque was observed in 1140 (43.5%) subjects and CACS>0 in 1172 (44.7%) subjects.

Plaque 40

Plaque Coronary Artery Disease Ultrasound Atherosclerosis 40

Dr. Paddy Barrett

FEBRUARY 27, 2024

The reason: They were accumulating plaque in their coronary arteries much earlier than their peers. You can’t have a heart attack if you don’t have plaque in your coronary arteries. And plaque in your coronary arteries is the result of exposure to risk factors over time. The answer: Risk Factors. The answer.

Risk Factors 107

Risk Factors Heart Disease Heart Attack Heart attacks 107

AMS Cardiology

JANUARY 21, 2023

We all want to be heart-healthy and ensuring our cholesterol levels are in the normal range is one of the most critical steps. High cholesterol can increase your risk of severe conditions like heart disease and heart attacks. Continue reading to learn four heart-healthy habits that can improve your cholesterol.

Cholesterol 40

Cholesterol Diet Blood Pressure Heart attacks 40

Dr. Paddy Barrett

OCTOBER 4, 2024

Everyone starts with no plaque in the coronary arteries, but over a long enough time frame, everyone develops plaque in their coronary arteries. By age 80, almost everyone will have evidence of advanced plaque in their coronary arteries, as defined by a cardiac CT 1. Plaque accumulation happens in stages. You got it.

Heart Disease 74

Heart Disease Plaque Cholesterol Risk Factors 74

Dr. Paddy Barrett

DECEMBER 19, 2023

You cannot eliminate the plaque entirely, but multiple clinical trials have shown plaque regression using high-intensity cholesterol-lowering treatments, which I have discussed previously. All of these parameters are important and need to be considered when evaluating plaque regression. REVERSAL Investigators.

Coronary Artery Disease 105

Coronary Artery Disease Plaque Exercise Heart attacks 105

Heart 2023 Conference

MARCH 17, 2023

Atherosclerosis, also called " hardening of the arteries, " occurs when fat, cholesterol and other substances are deposited in the walls of the arteries. These deposits are called plaques. Over time, these plaques can narrow or completely block arteries and cause problems throughout the body.

Atherosclerosis 52

Atherosclerosis Exercise Plaque Cholesterol 52

Dr. S. Venkatesan MD

JANUARY 8, 2024

10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. LDL is obviously a target against atherosclerosis. Chasing LDL cholesterol to the bottom — PCSK9 in perspective. Preamble 15 % of body weight is fat. Mind you LDL constitutes.000025%

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Dr. Paddy Barrett

JANUARY 23, 2024

However, most adults will start to develop advanced plaque in their coronary arteries early in life. By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque.

Heart Disease 94

Heart Disease Blood Pressure Dementia Atherosclerosis 94

Stroke Journal

NOVEMBER 9, 2023

This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease. Indirect data support such an approach in man.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

Dr. Paddy Barrett

AUGUST 1, 2023

A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone. A CT CAC scan of 0 indicates no significant amount of calcified atherosclerosis.

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies​.

Blood Pressure 52

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 52

Physiologically Speaking

FEBRUARY 23, 2024

Specifically, eating a meal containing 25 grams of protein or more activates the mammalian target of rapamycin complex 1 (mTORC1) and inhibits autophagy in immune cells known as macrophages, which promote the buildup of plaque and cholesterol in arteries, a process known as atherosclerosis. Wordplay is not my forte).

Physiology 107

Physiology Atherosclerosis Diet Cardiovascular Disease 107

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. 4 In the U.S.

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

GEMMS

NOVEMBER 22, 2023

Factors such as smoking, high blood pressure, high cholesterol levels, obesity, and a sedentary lifestyle significantly increase the risk of developing cardiovascular disease. This process, known as atherosclerosis, increases the risk of heart disease, heart attacks, and strokes.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Dr. Paddy Barrett

JULY 12, 2024

If you have high LDL cholesterol and are unsure what that means for your risk of heart disease, this article is for you. Over the course of your lifetime, your LDL cholesterol will slowly increase. By midlife, the average male and female will see a significant rise in their LDL cholesterol. to 4 mmol (135 to 155 mg/dl).

Cholesterol 90

Cholesterol Heart attacks Heart Attack Blood Pressure 90

Heart 2023 Conference

APRIL 20, 2022

In patients who are not taking statins, Esperion announced that bempedoic acid with or without ezetimibe (Nexletol/Nexlizet) can lower LDL cholesterol by more than 25%. JACC: Asia) Lexaria Bioscience has announced that a CBD product beats a placebo in simulating acute pulmonary hypertension.

Pulmonary 52

Pulmonary Hypertension AFIB COVID-19 52

DAIC

MAY 16, 2024

PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. This plaque narrows the blood vessels and reduces blood flow to the legs and feet, which may significantly impair physical function, walking performance and quality of life.

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Quality of Life Ischemia 105

Frontiers in Cardiovascular Medicine

FEBRUARY 16, 2024

Introduction Atherosclerosis is a chronic inflammatory disease caused by the deposition of lipids within the artery wall. During atherogenesis, efficient autophagy is needed to facilitate efferocytosis and cholesterol efflux, limit inflammation and lipid droplet buildup, and eliminate defective mitochondria and protein aggregates.

Atherosclerosis 64

Atherosclerosis Plaque Diet Cholesterol 64

Dr. Paddy Barrett

MAY 31, 2024

Heart disease, the build-up of plaque in the coronary arteries, typically starts years, if not decades, prior to an event. These noninvasive scans look directly at the coronary arteries rather than assessing for the risk factors for coronary artery disease eg LDL cholesterol, high blood pressure etc. As the line goes, “No Plaque.

Heart Disease 78

Heart Disease Plaque Heart attacks Heart Attack 78

Wellnest

DECEMBER 21, 2022

Coronary artery disease Excessive cholesterol builds up plaque that blocks the arteries supplying blood to the heart. This condition is also called atherosclerosis. An ECG machine is able to detect other abnormalities of the heart as well, such as hypertrophic cardiomyopathy or overly thick heart muscles.

Cardiac Arrest 52

Cardiac Arrest Heart attacks Heart Attack Atrial Fibrillation 52

Stroke Journal

JANUARY 21, 2024

BACKGROUND:Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques. Plaque stability was determined by gold-standard histological classifications. Adipokine, lipid, and immune profiling was conducted.

Plaque 40

Plaque Circulation Atherosclerosis Hemorrhage 40