JAMA Cardiology

NOVEMBER 5, 2024

Aortic stenosis (AS) due to fibrosis and calcification of the aortic valve is a hazardous component of cardiovascular disease burden—after developing symptomatic AS, patients survive for an average of less than 2 years without treatment.

Atherosclerosis 53

Atherosclerosis Aortic Stenosis Aortic valve 53

Dr. Paddy Barrett

FEBRUARY 27, 2024

Presence of atherosclerosis with LDL-C and HBA1c in the ‘normal range’ What the above graph shows is that for those with an LDL-C of 3.4 mmol/l (130 mg/dl) or below, between 20-50% will already have coronary artery disease. For many of our traditional risk factors, normal does not mean optimal 4. JAMA Cardiol.

Risk Factors 111

Risk Factors Heart Disease Heart Attack Heart attacks 111

Dr. Paddy Barrett

DECEMBER 13, 2024

When it comes to cardiovascular disease, two of the biggest risk factors we must consider are: ApoB concentration - A measure of the number of circulating lipid particles. ApoB Atherosclerosis, by definition, is caused by the retention of an ApoB lipid particle in the artery wall. Mechanism of atherosclerosis formation.

Heart Disease 97

Heart Disease BMI Diabetes Cardiovascular Disease 97

Dr. Paddy Barrett

JANUARY 23, 2024

Cardiovascular disease is the leading cause of death worldwide. Over 80% of early heart disease is preventable. However, most adults will start to develop advanced plaque in their coronary arteries early in life. Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque.

Heart Disease 105

Heart Disease Blood Pressure Dementia Atherosclerosis 105

DAIC

JULY 25, 2024

“We are encouraged by the implementation of our AI cardiac solution at esteemed healthcare systems, along with the continued validation through real-world studies of its potential to promote early detection and preventive care of cardiovascular disease,” said Erez Meltzer, Nanox Chief Executive Officer and Acting Chairman. “We

Innovation 105

Innovation Coronary Artery Disease Hospital Cardiovascular Disease 105

Circulation

DECEMBER 28, 2023

Using mediation Mendelian randomization, we explored proteomic mediators of the effects of genetically proxied IL-6 signaling on coronary artery disease, large artery atherosclerotic stroke, and peripheral artery disease.

Atherosclerosis 49

Atherosclerosis Peripheral Arterial Disease Coronary Artery Disease Pharmacology 49

Circulation

NOVEMBER 11, 2024

Background:The role of immune suppressive microenvironment, promulgated by the presence of Myeloid Derived Suppressor Cells (MDSC) have been the major focus of research delineating the underlying mechanisms of cardiovascular diseases (CVD). 3ng/day for 15 days).M-MDSCs

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Dr. Paddy Barrett

JUNE 7, 2024

Appreciating this distinction is critical to understanding heart disease. Heart disease is the presence of plaque or atherosclerosis in the coronary arteries. The ‘Event’ is caused by the ‘Disease’, atherosclerosis in this instance. Disease : Coronary Atherosclerosis.

Heart Disease 94

Heart Disease Heart Attack Heart attacks Plaque 94

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

All About Cardiovascular System and Disorders

SEPTEMBER 29, 2023

Climbing more than five flights of stairs every day can reduce the risk of atherosclerotic cardiovascular disease by over 20% according to a study using data from the UK Biobank, published in the journal Atherosclerosis [1]. Similar results were noted for both coronary artery disease and ischemic stroke.

Heart Disease 52

Heart Disease Coronary Artery Disease Cardiovascular Disease Atherosclerosis 52

DAIC

OCTOBER 15, 2024

In the United States, one person dies every 33 seconds from cardiovascular disease. The sooner these plaques are detected, the sooner effective therapies to prevent plaque rupture can be started."

Plaque 52

Plaque Medicare Chest Pain Coronary Artery Disease 52

Physiologically Speaking

JANUARY 5, 2024

Exercise prevents and reverses cardiovascular disease, but whether high-intensity exercise training (HIIT) is safe and effective for adults after minimally invasive heart surgery is unknown. Exercise is a wonder drug for cardiovascular disease (CVD) prevention and reversal.

Plaque 119

Plaque Physiology Exercise Cholesterol 119

The British Journal of Cardiology

APRIL 16, 2024

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide, causing around 17.9 million deaths annually, a third of whom are adults aged <70 years.

Cardiovascular Disease 40

Cardiovascular Disease Public Health Diet Risk Factors 40

Stroke Journal

NOVEMBER 9, 2023

The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease. Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023.

Strokes 40

Strokes Stroke Atherosclerosis Coronary Artery Disease 40

DAIC

MAY 16, 2024

PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S.

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Dr. Paddy Barrett

OCTOBER 31, 2023

An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

Dr. Paddy Barrett

AUGUST 22, 2023

However Most people do not appreciate that being a carrier of APOE4 significantly increases the risk of cardiovascular disease also. Share For those with defective LDL receptors, as seen in familial hyperlipidemia, APOB particles are not cleared effectively, and concentrations rise, causing atherosclerosis 4. The answer is yes.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Dr. Smith's ECG Blog

NOVEMBER 15, 2023

Angiogram No obstructive epicardial coronary artery disease Cannot exclude non-ACS causes of troponin elevation including coronary vasospasm, stress cardiomyopathy, microvascular disease, etc. See "Mechanisms of acute coronary syndromes related to atherosclerosis".) Lindahl et al. From Gue at al.

Coronary Angiogram 109

Coronary Angiogram Plaque Thrombosis STEMI 109

Dr. Paddy Barrett

SEPTEMBER 5, 2023

Share Let’s first state our goal when we are in the business of ‘Heart Disease Prevention’: To delay the onset of coronary artery disease (atherosclerosis/plaque) that might rupture and cause a heart attack. Not any more. Here’s why. The answer is Yes. Time to get to it. J Am Coll Cardiol.

Plaque 52

Plaque Heart Attack Heart attacks Exercise 52

Dr. Smith's ECG Blog

NOVEMBER 30, 2022

Hospital Course The patient was taken emergently to the cath lab which did not reveal any significant coronary artery disease, but she was noted to have reduced EF consistent with Takotsubo cardiomyopathy. See "Mechanisms of acute coronary syndromes related to atherosclerosis".) Lindahl et al.

Plaque 52

Plaque Chest Pain Thrombosis Stenosis 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

They are also at an increased risk of coronary artery disease (Discussed in more detail here ). My advice to patients concerned about the risk of dementia when considering starting lipid-lowering therapy and who are also at high risk of cardiovascular disease is that the benefits are much more likely to outweigh the risks.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Dr. Paddy Barrett

MAY 31, 2024

The most common way to assess the presence and extent of coronary artery disease is with a CT scan, called a CT CAC score or CT Coronary Angiogram. CT Coronary Angiogram. Atherosclerosis in the proximal segment of the vessel. It is a marker of where someone is on a disease progression pathway.

Heart Disease 94

Heart Disease Plaque Heart Attack Heart attacks 94

Dr. Paddy Barrett

OCTOBER 10, 2023

Even in those with documented coronary artery disease, less than half were on statin therapy, which has been repeatedly proven to decrease risk in this high-risk group 1. While there is no approved therapy to directly lower Lp(a) levels, that does not mean overall cardiovascular risk cannot be reduced. J Am Coll Cardiol.

Risk Factors 52

Risk Factors Heart Disease Blood Pressure Coronary Artery Disease 52

DAIC

APRIL 4, 2024

Image courtesy: RSNA christine.book Thu, 04/04/2024 - 11:26 April 4, 2024 — A new study found increased coronary vessel wall thickness that was significantly associated with impaired diastolic function in asymptomatic, middle-aged individuals living with HIV. Gharib, M.D. Abd-Elmoniem, Ph.D.,

Coronary Artery Disease 40

Coronary Artery Disease Cardiovascular Disease Cardiothoracic Sudden Cardiac Death 40

Physiologically Speaking

APRIL 24, 2024

” ―William Shakespeare, Macbeth Sleep and cardiovascular disease: the epidemiological evidence Despite our knowledge that sleep is vital for human health and well being, we often neglect it. 13 Coronary artery calcification (CAC) and aortic stiffness are also associated with self-reported sleep duration.

Blood Pressure 52

Blood Pressure Blood Clot COVID-19 Cardiovascular Disease 52

Physiologically Speaking

DECEMBER 17, 2024

Coronary artery calcium (CAC) is a measure of atherosclerosis and a strong predictor of cardiovascular disease. This finding might seem alarming since higher CACS is generally associated with an elevated risk of cardiovascular disease (CVD). A new analysis helps us understand.

Risk Factors 105

Risk Factors Genetic predisposition Plaque Exercise 105

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Personalized Cardiometabolic Care TRANSFORM Program for Coronary Artery Disease (CAD) : The TRANSFORM program focuses on atherosclerosis-based care strategies rather than traditional risk-based approaches.

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59