Dr. Paddy Barrett

FEBRUARY 27, 2024

Presence of atherosclerosis with LDL-C and HBA1c in the ‘normal range’ What the above graph shows is that for those with an LDL-C of 3.4 mmol/l (130 mg/dl) or below, between 20-50% will already have coronary artery disease. 4 Primary Prevention of Subclinical Atherosclerosis in Young Adults: JACC Review Topic of the Week.

Risk Factors 112

Risk Factors Heart Disease Heart attacks Heart Attack 112

Circulation

NOVEMBER 11, 2024

Background:The role of immune suppressive microenvironment, promulgated by the presence of Myeloid Derived Suppressor Cells (MDSC) have been the major focus of research delineating the underlying mechanisms of cardiovascular diseases (CVD). 3ng/day for 15 days).M-MDSCs Further, CCR5 modulation expanded IL10+M-MDSCin vivo.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Diet 40

Physiologically Speaking

JANUARY 5, 2024

Exercise prevents and reverses cardiovascular disease, but whether high-intensity exercise training (HIIT) is safe and effective for adults after minimally invasive heart surgery is unknown. Exercise is a wonder drug for cardiovascular disease (CVD) prevention and reversal. HbA1c also didn’t change.

Plaque 119

Plaque Physiology Exercise Cholesterol 119

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundAortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome, leading to inflammation and cardiovascular diseases. mg/dL versus 97.9±37.6

Aortic valve 40

Aortic valve Cholesterol Aortic Stenosis 40

Circulation

NOVEMBER 11, 2024

Background:Serum lipids and ratios are known to be associated with cardiovascular disease (CVD). Conclusions:There is an L-shaped association between NHHR levels and atherosclerosis in adults in the United States, and controlling NHHR is clinically important for reducing the risk of developing atherosclerosis.

Cholesterol 40

Cholesterol Atherosclerosis Cardiovascular Disease Hypertension 40

Dr. Paddy Barrett

NOVEMBER 7, 2023

The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. It is the inflammatory response to this particle retention that causes the formation of atherosclerosis 1. Lipoprotein particles entering the subintimal space causing atherosclerosis. TG = Triglycerides.

Cholesterol 52

Cholesterol Atherosclerosis Stenosis Aortic 52

Frontiers in Cardiovascular Medicine

MARCH 4, 2024

Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absence of traditional risk factors.

Plaque 59

Plaque Coronary Artery Disease Blood Pressure Cardiovascular Disease 59

Cardiometabolic Health Congress

AUGUST 23, 2024

Newly included risk factors— untreated vision loss and high LDL cholesterol —underscore the critical role of these elements in maintaining cognitive health. The Cholesterol Connection Cholesterol’s recognition as a risk factor for dementia marks a pivotal advancement in understanding, preventing, and delaying cognitive decline.

Dementia 52

Dementia Cholesterol Risk Factors CME 52

GEMMS

NOVEMBER 22, 2023

By understanding the significance of cardiovascular health, we can make informed choices and adopt lifestyle habits that promote a strong and resilient heart. Risk factors for cardiovascular disease Understanding the risk factors for cardiovascular disease is crucial for maintaining optimal cardiovascular health.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Dr. Paddy Barrett

AUGUST 22, 2023

However Most people do not appreciate that being a carrier of APOE4 significantly increases the risk of cardiovascular disease also. APO E is also centrally involved in cholesterol metabolism. APO E is also centrally involved in cholesterol metabolism. i.e. LDL-Cholesterol/APOB goes down. Here’s how.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Coronary Artery Disease Journal

DECEMBER 1, 2024

Background Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease due to its unique apo(a) component and its association with atherosclerosis and thrombogenesis. to 1.20), total cholesterol, triglycerides, and Lp(a) levels while increasing high-density lipoprotein cholesterol levels.

Heart Disease 40

Heart Disease Cholesterol Myocardial Infarction Atherosclerosis 40

Journal of the American Heart Association

DECEMBER 19, 2024

BackgroundElevated lowdensity lipoprotein cholesterol is a risk factor for atherosclerotic cardiovascular disease, including acute ischemic stroke (AIS), due to large and smallvessel disease. Cholesterol management guidelines recommend lipidlowering therapy (LLT) to prevent atherosclerotic cardiovascular disease events.

Strokes 40

Strokes Stroke Cholesterol Cardiovascular Disease 40

Stroke Journal

NOVEMBER 9, 2023

Several mechanisms have been proposed to account for the association between HDAC9 and atherosclerosis including alterations in the inflammatory response and cholesterol efflux and endothelial-mesenchymal transition. Indirect data support such an approach in man.

Strokes 40

Strokes Stroke Atherosclerosis Coronary Artery Disease 40

Circulation

NOVEMBER 11, 2024

They contain dietary triglycerides, cholesterols, and apolipoproteins. In humans, genetic polymorphisms in apoC-III are directly tied to plasma triglyceride levels and cardiovascular disease risk. Circulation, Volume 150, Issue Suppl_1 , Page A4141400-A4141400, November 12, 2024.

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Atherosclerosis Circulation 40

Dr. Paddy Barrett

SEPTEMBER 19, 2023

I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest. At the exact same time, cholesterol concentrations are also at their lowest. Let’s break this down.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Dr. Paddy Barrett

OCTOBER 31, 2023

When there is a history of early events, then the likelihood of a member of that family with an elevated Lp(a) having premature coronary atherosclerosis is high. Better lifestyle factors significantly reduced the risk of coronary artery disease, but even with an optimal lifestyle pattern, there was a small increase in risk 2.

Coronary Artery Disease 52

Coronary Artery Disease Heart Disease Atherosclerosis Cardiovascular Disease 52

The British Journal of Cardiology

AUGUST 1, 2024

Lipoprotein(a) (Lp[a]) can improve the accuracy of assessment of atherosclerotic cardiovascular disease and the risk of aortic valve stenosis. Currently, there is no specific treatment to lower its circulating concentration. Raised Lp(a) is a feature of familial hypercholesterolaemia.

Aortic valve 40

Aortic valve Heart Disease Blood Pressure Stenosis 40

DAIC

MARCH 31, 2025

mg reduces the risk of major adverse cardiovascular events (MACE) and supports its use in the treatment of cardiovascular disease. mg)has potential to directly reduce inflammation, which plays a substantial role in the formation and progression of atherosclerotic plaque leading to heart disease, said Matthew J.

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

Cardiometabolic Health Congress

JANUARY 15, 2025

Atherosclerosisa key driver of cardiovascular disease (CVD)continues to be a significant global health issue. While advances in treatment have reduced mortality in some regions, the atherosclerosis prevention remains challenging. Urbanization, increased sedentary lifestyles, and unhealthy diets have fueled this trend.

Atherosclerosis 59

Atherosclerosis Plaque Myocardial Infarction Risk Factors 59

DAIC

JANUARY 23, 2024

Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

DAIC

FEBRUARY 1, 2024

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. per 1,000* - 122.4

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Strokes Stroke 104

DAIC

MARCH 31, 2025

mg reduces the risk of major adverse cardiovascular events (MACE) and supports its use in the treatment of cardiovascular disease. mg)has potential to directly reduce inflammation, which plays a substantial role in the formation and progression of atherosclerotic plaque leading to heart disease, said Matthew J.

Cardiovascular Disease 52

Cardiovascular Disease Plaque Coronary Artery Disease Heart attacks 52

DAIC

JANUARY 30, 2024

The new model, which ultimately could change how cardiovascular disease risk is assessed in doctors’ offices around the world, is described in a paper published online January 29 in the Journal of the American College of Cardiology. Parameters of the new model are available in the paper supplements.

Cardiovascular Disease 52

Cardiovascular Disease Research Heart attacks Heart Attack 52

Physiologically Speaking

FEBRUARY 23, 2024

However, a series of recent studies in mice and in humans reveals that protein may promote a cascade of events in the body that lead to cardiovascular disease. All of this is true, yet some observational studies (with all of their inherent flaws) have associated a high (animal) protein intake with cardiovascular disease risk.

Physiology 111

Physiology Atherosclerosis Diet Cardiovascular Disease 111

Frontiers in Cardiovascular Medicine

FEBRUARY 16, 2024

Introduction Atherosclerosis is a chronic inflammatory disease caused by the deposition of lipids within the artery wall. During atherogenesis, efficient autophagy is needed to facilitate efferocytosis and cholesterol efflux, limit inflammation and lipid droplet buildup, and eliminate defective mitochondria and protein aggregates.

Atherosclerosis 64

Atherosclerosis Plaque Diet Cholesterol 64

DAIC

MAY 29, 2024

Data presented today by AstraZeneca , at the European Atherosclerosis Society (EAS) Congress in France, on AZD0780, an oral PCSK9 inhibitor demonstrated significant LDL-C reduction on top of statin in Phase I trial. Elevated LDL-C levels in plasma is a key risk factor for cardiovascular disease and is estimated to cause 2.6

Cholesterol 52

Cholesterol Atherosclerosis Cardiovascular Disease Myocardial Infarction 52

Dr. Paddy Barrett

JANUARY 23, 2024

Cardiovascular disease is the leading cause of death worldwide. Over 80% of early heart disease is preventable. Share While the average Western male and female will develop advanced coronary artery disease by age 55 and 66, respectively, 85% of the Tsimane tribe population over 40 had no evidence of advanced atherosclerosis 2.

Heart Disease 106

Heart Disease Blood Pressure Dementia Atherosclerosis 106

Heart 2023 Conference

APRIL 20, 2022

Avocado consumption of at least two servings per week is linked to a lower risk of cardiovascular disease. Harvard University Heart Letter) A clinical polygenic risk score test for diseases ranging from atrial fibrillation (AFib) to breast cancer was piloted by scientists.

Pulmonary 52

Pulmonary Hypertension AFIB COVID-19 52

All About Cardiovascular System and Disorders

DECEMBER 15, 2023

CLEAR Trial of Bempedoic Acid Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. CLEAR trial had patients for both primary and secondary prevention of cardiovascular disease. Median follow up was for 40.6 There was 29.2 Nat Commun.

Cholesterol 52

Cholesterol Myocardial Infarction Cardiovascular Disease Diabetes 52

DAIC

MAY 16, 2024

PAD is a serious, progressive cardiovascular disease primarily caused by a buildup of fatty plaque in the blood vessels, or atherosclerosis. Among those ages 65 and older, nearly 50% who underwent limb amputation died within one year after surgery, according to the 2024 Heart Disease and Stroke Statistics: A Report of U.S.

Peripheral Arterial Disease 105

Peripheral Arterial Disease Exercise Ischemia Quality of Life 105

Circulation: Cardiovascular Imaging

FEBRUARY 4, 2025

Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Immune checkpoint inhibitors (ICIs), though revolutionary in cancer treatment, may accelerate atherosclerosis by inducing arterial inflammation. Baseline arterial [18F]FDG uptake correlated with traditional cardiovascular risk factors, such as body mass index and male sex.

Cancer 40

Cancer Atherosclerosis Cardiovascular Imaging Cholesterol 40

The Beat Blog

MARCH 30, 2022

Cardiovascular diseases (CVD) affect nearly half of all American adults, and in addition to their impact on health outcomes, they have significant economic implications. are associated with these conditions, the largest across all disease categories. 17% of all annual healthcare costs in the U.S.

Blood Pressure 52

Blood Pressure Diabetes Risk Factors Hypertension 52

Physiologically Speaking

MARCH 6, 2024

But the rising trends of obesity, diabetes, and cardiovascular disease and the falling trend of activity levels lead me to a dark conclusion: things probably aren’t going to get any better. Statins lower cholesterol. Cardiovascular diseases are the leading cause of death around the world. Nor should it be.

Exercise 92

Exercise Blood Pressure Risk Factors Physiology 92

Dr. Paddy Barrett

MAY 31, 2024

These noninvasive scans look directly at the coronary arteries rather than assessing for the risk factors for coronary artery disease eg LDL cholesterol, high blood pressure etc. Atherosclerosis in the proximal segment of the vessel. Atherosclerosis, or plaque, is a progressive condition that occurs in stages over decades.

Heart Disease 96

Heart Disease Plaque Heart attacks Heart Attack 96

Dr. Paddy Barrett

OCTOBER 10, 2023

Lipoprotein (a) Approximately 1 in 5 people have the Lp(a) variant of cholesterol particle that significantly increases the risk of early heart disease and stroke. It is genetically mediated, so if you have an early family history of heart disease, this is something to consider 2. J Am Coll Cardiol. 2 Duarte Lau F, Giugliano RP.

Risk Factors 52

Risk Factors Heart Disease Blood Pressure Coronary Artery Disease 52

Frontiers in Cardiovascular Medicine

MARCH 3, 2025

Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic cardiovascular disease continues to exhibit high morbidity and mortality rates.

Atherosclerosis 52

Atherosclerosis Cholesterol Research Cardiovascular Disease 52

Cardiometabolic Health Congress

NOVEMBER 22, 2024

Another promising advancement is MK-0616 , an oral PCSK9 inhibitor in Phase 3 trials, showing a significant reduction in LDL cholesterol, which provides a more convenient alternative to current injection-based therapies​.

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59