Science Daily - Heart Disease

SEPTEMBER 18, 2024

The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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Cardiovascular Disease Plaque Atherosclerosis Risk Factors 118

Frontiers in Cardiovascular Medicine

APRIL 3, 2025

Beyond its role in circadian rhythm regulation, REV-ERB could significantly influence physiological and pathological processes related to cardiovascular health, including atherosclerosis, myocardial ischemia/reperfusion injury, and heart failure.

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Cardiovascular Disease Atherosclerosis Physiology Heart Failure 40

The British Journal of Cardiology

DECEMBER 3, 2024

This year, the cholesterol charity took on an international theme, looking at the global cardiovascular disease (CVD) prevention picture. There was also a particular focus on women and CVD disease, alongside a review of how familial hypercholesterolaemia (FH) care has advanced in recent decades.

Cardiovascular Disease 40

Cardiovascular Disease Atherosclerosis Cholesterol 40

American College of Cardiology

APRIL 7, 2025

Chronic inflammation plays a role in the pathogenesis of cardiovascular diseases, including atherosclerosis, pericarditis, stroke, and myocardial infarction (MI).

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Atherosclerosis Myocardial Infarction Pericarditis Cardiovascular Disease 74

Science Daily - Heart Disease

NOVEMBER 13, 2024

Researchers have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

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Cardiovascular Disease Heart attacks Heart Attack Plaque 109

American College of Cardiology

JUNE 25, 2024

Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?

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Atherosclerosis Risk Factors Cardiovascular Disease Article 73

Cardiovascular Diabetology

AUGUST 23, 2024

Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.

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Kidney Disease Diabetes Atherosclerosis Cardiovascular Disease 129

Science Daily - Stroke

JANUARY 24, 2024

A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases.

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Atherosclerosis Cardiovascular Disease 114

Cardiovascular Diabetology

APRIL 8, 2025

Preeclampsia (PE) and type 1 diabetes (T1D) are significant risk factors for cardiovascular disease (CVD), but their combined effect on atherosclerosis progression has not been fully explored. This study aimed.

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Atherosclerosis Diabetes Risk Factors Cardiovascular Disease 69

Nature Reviews - Cardiology

APRIL 9, 2024

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01016-y In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment (..)

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Atherosclerosis Cardiovascular Disease 81

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties.

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Atherosclerosis Cholesterol Cardiovascular Disease Plaque 122

Nature Reviews - Cardiology

JANUARY 11, 2024

Nature Reviews Cardiology, Published online: 12 January 2024; doi:10.1038/s41569-023-00984-x In this Review, Fredman and Serhan discuss the role of specialized pro-resolving mediators, a superfamily of endogenous signalling lipids that mediate resolution of inflammation processes in atherosclerosis, and appraise the therapeutic potential of specialized (..)

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Cardiovascular Disease Atherosclerosis 98

Nature Reviews - Cardiology

APRIL 24, 2024

Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01023-z In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies (..)

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Atherosclerosis Cardiovascular Disease 64

The New England Journal of Medicine

AUGUST 30, 2024

Taking a long-term view of cardiovascular disease prevention is an attractive strategy since atherosclerosis begins early in life and progresses over decades. Lowering low-density lipoprotein (LDL) cholesterol levels and improving lifestyle habits are mainstay strategies for reducing the risk of cardiovascular disease.1

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Cardiovascular Disease Atherosclerosis Cholesterol 60

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

In recent issues of the JCI, two independent papers highlight a direct role of endothelial LDs in the genesis of hypertension and atherosclerosis in rodent models. demonstrated that accumulation of LDs in the endothelium leads to hypertension, impairs endothelial function, and accelerates atherosclerosis. Boutagy, Gamez-Mendez, et al.

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Cardiovascular Disease Atherosclerosis Physiology Hypertension 93

Frontiers in Cardiovascular Medicine

JUNE 3, 2024

Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) serve as the initial and pivotal enzymes of the KP, with IDO playing important and intricate roles in cardiovascular diseases. Multiple studies have indicated that kynurenine (KYN) may serve as a potential biomarker for several adverse cardiovascular events.

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Cardiovascular Disease Atherosclerosis Myocardial Infarction Physiology 52

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

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Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 57

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally. Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic acid (NA) metabolism across various organisms. They play a pivotal role in gene expression, inflammatory response, lipid metabolism, and so forth.

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Cardiovascular Disease Myocardial Infarction Atherosclerosis Cancer 64

Cardiovascular Diabetology

OCTOBER 25, 2024

Atherosclerotic cardiovascular diseases remain the leading cause of mortality in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of atherosclerosis, which is exacerbate.

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Atherosclerosis Diabetes Cardiovascular Disease Research 52

Frontiers in Cardiovascular Medicine

AUGUST 7, 2024

In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease.

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Cardiovascular Disease Myocardial Infarction Atherosclerosis Biomarkers 52

Science Daily - Heart Disease

FEBRUARY 19, 2024

Researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease.

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Heart Disease Heart attacks Heart Attack Atherosclerosis 118

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

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Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously unrecognized, potent, age-related, and common risk factor for atherosclerosis. Cardiovascular disease accounts for much of this gap. Experimental evidence supports the causality of certain CHIP mutations in accelerated atherosclerosis.

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Atherosclerosis Risk Factors Cardiovascular Disease 49

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

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Atherosclerosis Plaque Cardiovascular Disease 59

Journal of Cardiothoracic Surgery

JANUARY 16, 2025

Atherosclerosis (AS) is increasingly recognized as a chronic inflammatory disease that significantly compromises vascular health and acts as a major contributor to cardiovascular diseases. Advancements in lipi.

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Atherosclerosis Biomarkers Cardiovascular Disease Research 52

Cardiovascular Diabetology

JANUARY 5, 2024

Findings from earlier research have established that insulin resistance (IR) is implicated in atherosclerosis progression, representing a noteworthy risk factor for cardiovascular disease (CVD). Recently, the.

Cardiovascular Disease 59

Cardiovascular Disease Atherosclerosis Risk Factors Research 59

Heart BMJ

JUNE 25, 2024

Methods A total of 2412 participants who underwent both chest CT and ECG-gated cardiac CT at the same period were included in the Multi-Ethnic Study of Atherosclerosis Exam 5. All participants were monitored for incident atherosclerotic cardiovascular disease (ASCVD) events.

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Cardiovascular Disease Aortic Atherosclerosis 59

Frontiers in Cardiovascular Medicine

JULY 2, 2024

Cardiovascular diseases account for a significant portion of the worldwide mortality rate. This aroused interest among the specialised scientific community, seeking for solutions based on non-clinical and clinical investigations, to shed light onto the physio-pathology of cardiovascular impairment.

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Atherosclerosis Cardiovascular Disease Physiology Biomarkers 52

JAMA Cardiology

NOVEMBER 5, 2024

Aortic stenosis (AS) due to fibrosis and calcification of the aortic valve is a hazardous component of cardiovascular disease burden—after developing symptomatic AS, patients survive for an average of less than 2 years without treatment.

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Atherosclerosis Aortic Stenosis Aortic valve 55

Frontiers in Cardiovascular Medicine

JUNE 30, 2024

Cardiovascular disease (CVD) represents the leading cause of mortality and disability all over the world. In this article, we first describe how ERK signaling contributes to preserving cardiovascular health.

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Cardiovascular Disease Quality of Life Myocardial Infarction Aneurysm 52

Dr. Paddy Barrett

DECEMBER 13, 2024

When it comes to cardiovascular disease, two of the biggest risk factors we must consider are: ApoB concentration - A measure of the number of circulating lipid particles. ApoB Atherosclerosis, by definition, is caused by the retention of an ApoB lipid particle in the artery wall. Mechanism of atherosclerosis formation.

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Heart Disease BMI Cardiovascular Disease Diabetes 98

Medical Xpress - Cardiology

FEBRUARY 22, 2024

Men who were physically fit when they were young had a lower risk of atherosclerosis almost 40 years later, according to a study led by researchers at Linköping University, Sweden.

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Atherosclerosis Cardiovascular Disease Research 45

DAIC

FEBRUARY 3, 2025

This clearance comes in advance of disease-modifying therapies on the horizon expected to help clinicians use this biomarker to guide patients to improved cardiovascular health, saidBrad Moore, president and CEO at Roche Diagnostics North America. 2022 Aug, 80 (9) 934946 Kronenberg F. J Clin Lipidol. 2024 May-Jun;18(3):e308-e319.

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Journal of the American Heart Association

JANUARY 22, 2025

BackgroundThis study examined the longitudinal associations of psychosocial stress subgroups with cardiovascular disease (CVD) events and whether social support, neighborhood cohesion, and physical activity modified these associations in MESA (MultiEthnic Study of Atherosclerosis).Methods

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Atherosclerosis Cardiovascular Disease 40

Journal of the American Heart Association

MARCH 31, 2025

Sensitivity analysis further tested the robustness of findings after accounting for prevailing levels of cardiovascular disease risk and brain imaging data quality. Brain areas where functional magnetic resonance imaging activity exhibited reliable direct and indirect effects were identified through bootstrapping.

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Atherosclerosis Blood Pressure Cardiovascular Disease 40

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Metabolic syndrome, today affecting more than 20% of the US population, is a group of 5 conditions that often coexist and that strongly predispose to cardiovascular disease. How these conditions are linked mechanistically remains unclear, especially two of these: obesity and elevated blood pressure.

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Blood Pressure Obesity Pharmacology Diet 105

Cardiology Update

JANUARY 12, 2025

Hashtag: #HeartFailure2025 European Atherosclerosis Society (EAS) Congress 2025 Date: May 4-7, 2025 Location: Glasgow, UK and online Overview: The European Atherosclerosis Society (EAS) and the British Atherosclerosis Society (BAS) will be hosting the 93 rd EAS Congress, to be held in the city of Lyon.

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Heart Failure Atherosclerosis Heart Rhythm Nursing 52