DAIC

JANUARY 23, 2024

1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. However, the development of atherosclerosis is now known to be much more complex, with a key role for immune cells and inflammation in conjunction with hyperlipidemia and elevated LDL levels.7

Cardiovascular Disease 111

Cardiovascular Disease Heart attacks Heart Attack Coronary Artery Disease 111

Open Heart

MARCH 24, 2023

The pathophysiology of calcific AS (CAS) is complex, yet can be characterised similarly to that of atherosclerosis. Novel approaches are developing to address this through: (1) screening with circulating biomarkers; (2) development of drugs to slow disease progression and (3) early valve intervention guided by medical imaging.

Stenosis 52

Stenosis Aortic Aortic valve Biomarkers 52

Circulation: Heart Failure

MARCH 1, 2024

Circulation: Heart Failure, Ahead of Print. Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. BACKGROUND:Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF).

Heart Failure 40

Heart Failure Preserved Ejection Fraction Risk Factors Atherosclerosis 40

Dr. Paddy Barrett

AUGUST 22, 2023

In general, for an APOB particle to be cleared from circulation, it attaches to an LDL receptor in the liver and is cleared from circulation. Share For those with defective LDL receptors, as seen in familial hyperlipidemia, APOB particles are not cleared effectively, and concentrations rise, causing atherosclerosis 4.

Cholesterol 52

Cholesterol Dementia Cardiovascular Disease Coronary Artery Disease 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

The cholesterol circulating in your bloodstream represents a very small fraction of your body’s total available cholesterol. Even if you were to reduce the circulating cholesterol in your bloodstream by 99%, you would still have more than enough cholesterol in your peripheral tissues and red blood cells 4. Atherosclerosis.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Circulation: Cardiovascular Imaging

FEBRUARY 19, 2024

Circulation: Cardiovascular Imaging, Volume 17, Issue 2 , Page e016057, February 1, 2024. 18F-flourodeoxyglucose resting amygdalar uptake, an imaging biomarker of stress-related neural activity, coronary inflammation (fat attenuation index), and high-risk plaque characteristics were assessed by coronary computed tomography angiography.

Atherosclerosis 40

Atherosclerosis Plaque Coronary Artery Disease Biomarkers 40

Physiologically Speaking

MAY 17, 2024

Most of the evidence on the harms of extreme exercise is related to a biomarker of cardiovascular disease known as coronary artery calcification or CAC. Exercise and Coronary Atherosclerosis | Circulation What’s lacking, however, is good data on long-term survival and lifespan among “extreme exercisers.”

Physiology 98

Physiology Exercise Biomarkers Cardiovascular Disease 98

Dr. Smith's ECG Blog

JANUARY 3, 2022

4] CT revealed no dissection but extensive coronary atherosclerosis. So even without the diagnostic ECGs, they had clinical evidence of refractory ischemia with biomarker (troponin) confirmation. Circulation 2014 7. -- McLaren JTT, Meyers HP, Smith SW, Chartier LB. In a study last year, 14.4% of those with posterior MI.[4]

STEMI 52

STEMI Myocardial Infarction Chest Pain Ischemia 52