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Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques

Frontiers in Cardiovascular Medicine

The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. EVs were isolated from serum by precipitation.

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American Heart Month Puts Spotlight on Cardiovascular Disease and Stroke Statistics

DAIC

February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. percent Compound Annual Growth Rate (CAGR).

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Coronary Artery Calcification: Current Concepts and Clinical Implications

Circulation

Circulation, Volume 149, Issue 3 , Page 251-266, January 16, 2024. Coronary artery calcification (CAC) accompanies the development of advanced atherosclerosis. Nevertheless, the relationship between CAC and the susceptibility of a plaque to provoke a thrombotic event remains incompletely understood.

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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk

DAIC

1,6 Until recently atherosclerosis has been thought of as the result of passive lipid accumulation in the vessel wall. However, the development of atherosclerosis is now known to be much more complex, with a key role for immune cells and inflammation in conjunction with hyperlipidemia and elevated LDL levels.7

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Pathophysiology, emerging techniques for the assessment and novel treatment of aortic stenosis

Open Heart

The pathophysiology of calcific AS (CAS) is complex, yet can be characterised similarly to that of atherosclerosis. Novel approaches are developing to address this through: (1) screening with circulating biomarkers; (2) development of drugs to slow disease progression and (3) early valve intervention guided by medical imaging.

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Metabolomic Association and Risk Prediction With Heart Failure in Older Adults

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. BACKGROUND:Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF).

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APOE4 & Cardiovascular Risk

Dr. Paddy Barrett

In general, for an APOB particle to be cleared from circulation, it attaches to an LDL receptor in the liver and is cleared from circulation. Share For those with defective LDL receptors, as seen in familial hyperlipidemia, APOB particles are not cleared effectively, and concentrations rise, causing atherosclerosis 4.