Science Daily - Heart Disease

SEPTEMBER 18, 2024

A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner.

Atherosclerosis 110

Atherosclerosis Technology Research Plaque 110

Frontiers in Cardiovascular Medicine

JANUARY 5, 2025

This mini review highlights the current knowledge about dysregulations in BA homeostasis in obesity with a special focus on atherosclerosis as well as athero-modulating roles of incretins and currently available incretin-based therapies. Moreover, incretin-based therapy has revolutionized the treatment of T2DM and obesity.

Obesity 52

Obesity Atherosclerosis Cardiovascular Disease Diabetes 52

DAIC

JULY 23, 2024

The International Atherosclerosis Society (IAS) has released a clinical proceedings white paper outlining the role of inflammation in atherosclerosis and the importance of early intervention. Systemic, chronic inflammation can also promote the advancement of atherosclerosis and increase the risk of developing cardiovascular diseases.

Atherosclerosis 110

Atherosclerosis Cardiovascular Disease Biomarkers Hospital 110

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Consistent with this mechanism, deletion of endothelial ATGL markedly increased lesion size in a model of atherosclerosis.

Atherosclerosis 126

Atherosclerosis Chronic Disease Physiology Circulation 126

Open Heart

FEBRUARY 11, 2025

This study aimed to evaluate the risk factors associated with LV mass and subclinical coronary atherosclerosis, in an Asian population free of baseline cardiovascular disease. Background Left ventricular (LV) mass is closely associated with atherosclerotic heart disease, but the mechanisms are not well defined.

Blood Pressure 52

Blood Pressure Atherosclerosis Risk Factors Hypertension 52

Nature Reviews - Cardiology

JANUARY 12, 2025

Nature Reviews Cardiology, Published online: 13 January 2025; doi:10.1038/s41569-024-01115-w In this Review, Khan and Jandeleit-Dahm discuss pathological mechanisms involved in atherosclerosis development and progression in patients with diabetes mellitus and highlight novel therapeutic targets to treat atherosclerosis in these patients.

Atherosclerosis 98

Atherosclerosis Diabetes 98

DAIC

DECEMBER 13, 2023

MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE. THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE'S CLINT L.

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Heart Attack Heart attacks Atherosclerosis Stroke 105

Medical Xpress - Cardiology

DECEMBER 12, 2023

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.

Heart Attack 105

Heart Attack Heart attacks Atherosclerosis Coronary Artery Disease 105

Science Daily - Stroke

JANUARY 13, 2024

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

Atherosclerosis 106

Atherosclerosis Research 106

Nature Reviews - Cardiology

SEPTEMBER 10, 2024

Can we resynchronize the immune system in atherosclerosis and save the king? After decades of research, the study of atheroimmunology has brought the first therapeutics to the clinic.

Atherosclerosis 97

Atherosclerosis Research 97

Science Daily - Heart Disease

SEPTEMBER 4, 2024

Our risk of developing atherosclerosis -- 'furring' of the arteries -- can begin much earlier in life than was previously thought, highlighting the need to keep cholesterol levels low even when we are young, new research has discovered.

Cholesterol 94

Cholesterol Atherosclerosis Risk Factors Research 94

Med Page Today

DECEMBER 4, 2023

(MedPage Today) -- The link between childhood blood pressure (BP) and adult atherosclerosis appeared stable going all the way back to infancy, suggesting that efforts to prevent arterial thickening may be beneficial starting at the earliest life.

Blood Pressure 97

Blood Pressure Atherosclerosis 97

Medical Xpress - Cardiology

NOVEMBER 13, 2024

Researchers at Case Western Reserve University have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.

Atherosclerosis 89

Atherosclerosis Heart Attack Heart attacks Plaque 89

Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Here, we examined the therapeutic potential of itaconate in atherosclerosis. Deletion of Acod1 in myeloid cells exacerbated inflammation and atherosclerosis in vivo and resulted in an elevated frequency of a specific subset of M1-polarized proinflammatory macrophages in the atherosclerotic aorta.

Atherosclerosis 98

Atherosclerosis Cholesterol 98

Nature Reviews - Cardiology

MAY 14, 2024

Nature Reviews Cardiology, Published online: 15 May 2024; doi:10.1038/s41569-024-01037-7 In this Review, Adkar and Leeper describe the mechanisms of programmed cell death and efferocytosis, discuss how efferocytosis becomes impaired in atherosclerosis and other cardiometabolic diseases, and suggest potential strategies to target these pathways for (..)

Atherosclerosis 76

Atherosclerosis Cardiovascular Disease 76

Medical Xpress - Cardiology

JANUARY 24, 2024

Atherosclerosis, a chronic inflammatory disease of the inner walls of blood vessels, is responsible for many cardiovascular conditions. Dendritic cells, which act to recognize foreign substances in the body and mount an immune response, play an important role in the disease.

Atherosclerosis 102

Atherosclerosis Research 102

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2025

IntroductionCardiovascular disease (CVD) caused by atherosclerosis (AS) remains the leading cause of mortality in developed countries. Targeting this cell-cell interaction may offer new therapeutic avenues for managing atherosclerosis.

Atherosclerosis 40

Atherosclerosis Plaque Research 40

Frontiers in Cardiovascular Medicine

FEBRUARY 12, 2025

BackgroundInflammation, as the basic pathogenic mechanism of atherosclerosis, promotes the development of atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD).

Atherosclerosis 52

Atherosclerosis Cardiovascular Disease Article 52

American College of Cardiology

JUNE 25, 2024

Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?

Atherosclerosis 73

Atherosclerosis Risk Factors Cardiovascular Disease Article 73

American College of Cardiology

APRIL 15, 2024

The following are key points to remember from a state-of-the-art review on the long-term safety of low-dose colchicine for atherosclerosis.

Atherosclerosis 75

Atherosclerosis Article 75

Science Daily - Heart Disease

FEBRUARY 26, 2025

Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.

Cholesterol 67

Cholesterol Coronary Artery Disease Plaque Heart Disease 67

Medical Xpress - Cardiology

MARCH 22, 2024

Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Diet-induced metabolic abnormalities including obesity, hyperglycemia, dyslipidemia, insulin resistance (IR), and non-alcoholic fatty liver disease are considered atherogenic risk factors.

Atherosclerosis 88

Atherosclerosis Diet Obesity Risk Factors 88

Nature Reviews - Cardiology

SEPTEMBER 19, 2024

Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01072-4 In this Review, the authors describe the bidirectional crosstalk between lysosome biology and immune cell function and polarization, focusing on immunometabolic reprogramming in the context of atherosclerosis and highlighting knowledge gaps and potential (..)

Atherosclerosis 76

Atherosclerosis 76

Nature Reviews - Cardiology

APRIL 9, 2024

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01016-y In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment (..)

Atherosclerosis 75

Atherosclerosis Cardiovascular Disease 75

Medical Xpress - Cardiology

JANUARY 15, 2024

A new 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials in a paper titled "Atherosclerotic three-layer nanomatrix (..)

Atherosclerosis 85

Atherosclerosis Research 85

Medical Xpress - Cardiology

JANUARY 23, 2024

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid have found that one of the most potent genetic risk factors for Alzheimer's disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.

Atherosclerosis 81

Atherosclerosis Risk Factors 81

Nature Reviews - Cardiology

JANUARY 1, 2024

In this Review, De Meyer and colleagues describe the various forms of programmed macrophage death in atherosclerosis and the potential therapeutic implications.

Atherosclerosis 78

Atherosclerosis Plaque 78

Medical Xpress - Cardiology

FEBRUARY 13, 2025

Atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events.

Atherosclerosis 59

Atherosclerosis Plaque 59

Nature Reviews - Cardiology

APRIL 24, 2024

Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01023-z In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies (..)

Atherosclerosis 59

Atherosclerosis Cardiovascular Disease 59

Stroke Journal

JANUARY 30, 2025

Introduction:Prior studies have shown the association between oral infection, white matter hyperintensity (WMH), a marker of cerebral small vessel disease (CSVD), and asymptomatic intracranial atherosclerosis (ICAS). However, the impact of preventative oral behavior such as dental flossing is unknown.

Atherosclerosis 75

Atherosclerosis Stenosis Risk Factors Education 75

Science Daily - Stroke

JANUARY 24, 2024

A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases.

Atherosclerosis 114

Atherosclerosis Cardiovascular Disease 114

Journal of the American Heart Association

FEBRUARY 19, 2025

This study examines the relationship between tHcy, HF overall, and HF subtype (HF with preserved ejection fraction [HFpEF] and HF with reduced ejection fraction) in the MultiEthnic Study of Atherosclerosis cohort.MethodsMultiEthnic Study of Atherosclerosis participants with baseline tHcy and HF data were included (N=6765).

Atherosclerosis 75

Atherosclerosis Heart Failure Preserved Ejection Fraction Diabetes 75

HCPLive

AUGUST 30, 2024

Sara Diaz Savaria, MD, discusses a study from ESC Congress 2024 examining the utility of cancer history in women as a predictor of subclinical atherosclerosis.

Atherosclerosis 59

Atherosclerosis Cancer 59

Nature Reviews - Cardiology

MARCH 25, 2025

Nature Reviews Cardiology, Published online: 26 March 2025; doi:10.1038/s41569-025-01149-8 A study published in Nature has identified two transmembrane G protein-coupled receptors that mediate extracellular-to-intracellular ceramide signalling and shows that blocking these receptors alleviates the atherosclerosis that is induced by a high-fat diet (..)

Atherosclerosis 52

Atherosclerosis Kidney Disease Diet 52

Cardiometabolic Health Congress

JUNE 20, 2024

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Shapiro (United States of America) focused on preventing atherosclerosis over myocardial infarction, suggesting that CAC’s late-stage detection does not fit classic definitions of primary prevention.

Atherosclerosis 59

Atherosclerosis Cardiovascular Disease Coronary Artery Disease Myocardial Infarction 59

Medical Xpress - Cardiology

FEBRUARY 20, 2025

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Germans Trias i Pujol Research Institute (IGTP) have studied variations in mRNA length during the progression of atherosclerosis in a mouse model.

Atherosclerosis 57

Atherosclerosis Biomarkers Research 57

American College of Cardiology

JULY 1, 2024

This expert opinion is based on Primary Prevention of Subclinical Atherosclerosis in Young Adults: JACC Review Topic of the Week.

Atherosclerosis 64

Atherosclerosis Article 64