Subclinical Atherosclerosis Burden Shapes All-Cause Mortality Risk
HCPLive
OCTOBER 1, 2024
Subclinical atherosclerosis burden and its progression are independently linked to the risk of death from any cause in asymptomatic individuals.
Atherosclerosis Related Topics 
Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Consistent with this mechanism, deletion of endothelial ATGL markedly increased lesion size in a model of atherosclerosis.
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Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis
Cardiovascular Diabetology
DECEMBER 18, 2023
Elevated glycated hemoglobin (HbA1c) is associated with a higher burden of subclinical atherosclerosis (SA). However, the association with SA of earlier insulin resistance markers is poorly understood. The stu.
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International Atherosclerosis Society Issues New White Paper Underscoring Inflammation's Role, Offering Key Recommendations
DAIC
JULY 23, 2024
The International Atherosclerosis Society (IAS) has released a clinical proceedings white paper outlining the role of inflammation in atherosclerosis and the importance of early intervention. Systemic, chronic inflammation can also promote the advancement of atherosclerosis and increase the risk of developing cardiovascular diseases.
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New 'Atherosclerosis Atlas' Sheds Light on Heart Attacks, Strokes
DAIC
DECEMBER 13, 2023
MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE. THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE'S CLINT L.
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Efferocytosis in atherosclerosis
Nature Reviews - Cardiology
MAY 14, 2024
Nature Reviews Cardiology, Published online: 15 May 2024; doi:10.1038/s41569-024-01037-7 In this Review, Adkar and Leeper describe the mechanisms of programmed cell death and efferocytosis, discuss how efferocytosis becomes impaired in atherosclerosis and other cardiometabolic diseases, and suggest potential strategies to target these pathways for (..)
Researchers develop nanoparticle technology for targeted diagnosis and treatment of atherosclerosis
Science Daily - Heart Disease
SEPTEMBER 18, 2024
A team developed a nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis, in a non-invasive manner.
Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Here, we examined the therapeutic potential of itaconate in atherosclerosis. Deletion of Acod1 in myeloid cells exacerbated inflammation and atherosclerosis in vivo and resulted in an elevated frequency of a specific subset of M1-polarized proinflammatory macrophages in the atherosclerotic aorta.
Researchers uncover new signaling pathway in the development of atherosclerosis
Medical Xpress - Cardiology
JANUARY 24, 2024
Atherosclerosis, a chronic inflammatory disease of the inner walls of blood vessels, is responsible for many cardiovascular conditions. Dendritic cells, which act to recognize foreign substances in the body and mount an immune response, play an important role in the disease.
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New 'atherosclerosis atlas' sheds light on heart attacks, strokes
Medical Xpress - Cardiology
DECEMBER 12, 2023
University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.
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Atheroimmunology: keeping the immune system in atherosclerosis in check
Nature Reviews - Cardiology
SEPTEMBER 10, 2024
Can we resynchronize the immune system in atherosclerosis and save the king? After decades of research, the study of atheroimmunology has brought the first therapeutics to the clinic.
High Blood Pressure in Babies Linked to Adult Atherosclerosis
Med Page Today
DECEMBER 4, 2023
(MedPage Today) -- The link between childhood blood pressure (BP) and adult atherosclerosis appeared stable going all the way back to infancy, suggesting that efforts to prevent arterial thickening may be beneficial starting at the earliest life.
Inflammation-reducing molecule provides a new target for treating atherosclerosis
Medical Xpress - Cardiology
NOVEMBER 13, 2024
Researchers at Case Western Reserve University have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Nature Reviews - Cardiology
JANUARY 1, 2024
In this Review, De Meyer and colleagues describe the various forms of programmed macrophage death in atherosclerosis and the potential therapeutic implications.
3D in vitro human atherosclerosis model for high-throughput drug screening
Science Daily - Stroke
JANUARY 13, 2024
A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.
Canonical and non-canonical roles of complement in atherosclerosis
Nature Reviews - Cardiology
APRIL 9, 2024
Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01016-y In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment (..)
Autoimmune Diseases and Coronary Atherosclerosis
American College of Cardiology
JUNE 25, 2024
Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?
Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis
Nature Reviews - Cardiology
SEPTEMBER 19, 2024
Nature Reviews Cardiology, Published online: 20 September 2024; doi:10.1038/s41569-024-01072-4 In this Review, the authors describe the bidirectional crosstalk between lysosome biology and immune cell function and polarization, focusing on immunometabolic reprogramming in the context of atherosclerosis and highlighting knowledge gaps and potential (..)
Low-Dose Colchicine for Atherosclerosis: Key Points
American College of Cardiology
APRIL 15, 2024
The following are key points to remember from a state-of-the-art review on the long-term safety of low-dose colchicine for atherosclerosis.
3D in vitro human atherosclerosis model for high-throughput drug screening
Medical Xpress - Cardiology
JANUARY 15, 2024
A new 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials in a paper titled "Atherosclerotic three-layer nanomatrix (..)
Scientists provide novel insights into the effects of alternate day fasting on atherosclerosis
Medical Xpress - Cardiology
MARCH 22, 2024
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Diet-induced metabolic abnormalities including obesity, hyperglycemia, dyslipidemia, insulin resistance (IR), and non-alcoholic fatty liver disease are considered atherogenic risk factors.
APOE genetic variants linked to Alzheimer's disease also associated with the development of subclinical atherosclerosis
Medical Xpress - Cardiology
JANUARY 23, 2024
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid have found that one of the most potent genetic risk factors for Alzheimer's disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.
Targeting immune cell recruitment in atherosclerosis
Nature Reviews - Cardiology
APRIL 24, 2024
Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01023-z In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies (..)
High cholesterol levels at a young age significant risk factor for atherosclerosis
Science Daily - Heart Disease
SEPTEMBER 4, 2024
Our risk of developing atherosclerosis -- 'furring' of the arteries -- can begin much earlier in life than was previously thought, highlighting the need to keep cholesterol levels low even when we are young, new research has discovered.
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Association between periodontal disease and atherosclerosis: a bibliometric analysis
Frontiers in Cardiovascular Medicine
NOVEMBER 14, 2024
BackgroundIn recent years, the relationship between periodontal disease (PD) and atherosclerosis (AS) has garnered significant scholarly attention. Keyword analysis reveals “atherosclerosis,” “periodontal disease,” “cardiovascular disease,” “Porphyromonas gingivalis,” and “periodontal pathogens” as research hotspots.
The causal relationship between 233 metabolites and coronary atherosclerosis: a Mendelian randomization study
Frontiers in Cardiovascular Medicine
DECEMBER 11, 2024
ConclusionThere is a close relationship between metabolites and the occurrence of coronary atherosclerosis. ConclusionThere is a close relationship between metabolites and the occurrence of coronary atherosclerosis.
Cholesterol crystals in the pathogenesis of atherosclerosis
Nature Reviews - Cardiology
NOVEMBER 17, 2024
Nature Reviews Cardiology, Published online: 18 November 2024; doi:10.1038/s41569-024-01100-3 Cholesterol crystals (CCs) have a pathogenic role in various cardiovascular diseases, particularly atherosclerosis.
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Tackling inflammation in atherosclerosis
Nature Reviews - Cardiology
MARCH 11, 2024
Nature Reviews Cardiology, Published online: 12 March 2024; doi:10.1038/s41569-024-01007-z Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis. (..)
Significance of the Wnt signaling pathway in coronary artery atherosclerosis
Frontiers in Cardiovascular Medicine
MARCH 21, 2024
Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.
Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis
Journal of Clinical Investigation - Cardiology
MARCH 1, 2024
Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties.
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Age-Related Somatic Mutations Implicated in Cardiovascular Death
Med Page Today
APRIL 29, 2024
(MedPage Today) -- Cardiovascular death had a strong tie to the somatic mutations that often accrue with aging in people with subclinical atherosclerosis, an observational study found. For asymptomatic people who had atherosclerosis detected by.
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In Women, History of Cancer Linked to Subclinical Atherosclerosis
HCPLive
AUGUST 30, 2024
Sara Diaz Savaria, MD, discusses a study from ESC Congress 2024 examining the utility of cancer history in women as a predictor of subclinical atherosclerosis.
Multi-modal transcriptomics: integrating machine learning and convolutional neural networks to identify immune biomarkers in atherosclerosis
Frontiers in Cardiovascular Medicine
NOVEMBER 25, 2024
In this investigation, our objective is to establish computational models elucidating molecular-level markers associated with atherosclerosis. Nevertheless, our current understanding of its pathogenesis remains imprecise.
Atherosclerosis Updates from the 92nd EAS Congress
Cardiometabolic Health Congress
JUNE 20, 2024
The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Shapiro (United States of America) focused on preventing atherosclerosis over myocardial infarction, suggesting that CAC’s late-stage detection does not fit classic definitions of primary prevention.
Biomechanics-mediated endocytosis in atherosclerosis
Frontiers in Cardiovascular Medicine
APRIL 4, 2024
Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis.
New signaling pathway uncovered, shedding fresh light on atherosclerosis
Science Daily - Stroke
JANUARY 24, 2024
A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases.
Revolutionizing Cardiovascular Health in Young Adults: Advancements in Preventing Subclinical Atherosclerosis For a Heart-Healthy Future
American College of Cardiology
JULY 1, 2024
This expert opinion is based on Primary Prevention of Subclinical Atherosclerosis in Young Adults: JACC Review Topic of the Week.
Constructing a competitive endogenous RNA network of EndMT-related atherosclerosis through weighted gene co-expression network analysis
Frontiers in Cardiovascular Medicine
JANUARY 9, 2024
Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.
Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial
Cardiovascular Diabetology
AUGUST 23, 2024
Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.
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Scientists find cancer-like features in atherosclerosis, spurring opportunity for new treatment approaches
Science Daily - Heart Disease
APRIL 30, 2024
Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.
Clonal hematopoiesis and atherosclerosis
Journal of Clinical Investigation - Cardiology
OCTOBER 1, 2024
Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a previously unrecognized, potent, age-related, and common risk factor for atherosclerosis. Experimental evidence supports the causality of certain CHIP mutations in accelerated atherosclerosis. Cardiovascular disease accounts for much of this gap.
Biomechanical factors and atherosclerosis localization: insights and clinical applications
Frontiers in Cardiovascular Medicine
JULY 24, 2024
Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed.
Challenges and opportunities in the management of type 2 diabetes in patients with lower extremity peripheral artery disease: a tailored diagnosis and treatment review
Cardiovascular Diabetology
JUNE 25, 2024
Lower extremity peripheral artery disease (PAD) often results from atherosclerosis, and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Individuals with T2DM exhibit a more severe manifes.
Aspirin and Cardiovascular Risk in Individuals With Elevated Lipoprotein(a): The Multi?Ethnic Study of Atherosclerosis
Journal of the American Heart Association
JANUARY 31, 2024
Methods and ResultsWe used data from the MESA (Multi‐Ethnic Study of Atherosclerosis), a prospective cohort study of individuals free of baseline cardiovascular disease. Due to potential confounding by indication, we matched aspirin users to nonusers using a propensity score based on CVD risk factors.
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