Article and Thrombolysis - Cardiovascular Update

IV Thrombolysis + Thrombectomy vs. Thrombectomy Alone for Acute Ischemic Stroke

American College of Cardiology

FEBRUARY 15, 2024

What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?

Thrombolysis

Thrombolysis Stroke Strokes Outcomes

Large-Bore Mechanical Thrombectomy vs. Catheter-Directed Thrombolysis for Treatment of Intermediate-Risk Pulmonary Embolism

American College of Cardiology

OCTOBER 29, 2024

The goal of the trial was to compare the efficacy and safety of large-bore mechanical thrombectomy (LBMT) with catheter-directed thrombolysis (CDT) in the treatment of intermediate-high risk pulmonary embolism (PE).

Thrombolysis

Thrombolysis Embolism Pulmonary Article

Multi-arm Optimization of Stroke Thrombolysis

American College of Cardiology

SEPTEMBER 10, 2024

The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.

Thrombolysis

Thrombolysis Stroke Strokes Article

Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillationâ€“Thrombolysis in Myocardial Infarction 48

American College of Cardiology

JULY 12, 2024

The ENGAGE AF-TIMI 48 trial sought to study the safety and efficacy of edoxaban, an oral direct factor Xa inhibitor, as compared with warfarin in the treatment of atrial fibrillation.

Myocardial Infarction

Myocardial Infarction Thrombolysis Atrial Fibrillation Article

Thrombolysis in Imaging-Eligible, Late-Window Patients to Assess the Efficacy and Safety of Tenecteplase

American College of Cardiology

FEBRUARY 20, 2024

The goal of the TIMELESS trial was to determine the efficacy and safety of tenecteplase administered between 4.5 and 24 hours after last known well time in patients with acute ischemic stroke and salvageable tissue on perfusion imaging.

Thrombolysis

Thrombolysis Stroke Strokes Article

Retraction: Anterior Circulation Thrombectomy in Patients With Low National Institutes of Health Stroke Scale Score: Analysis of the National Inpatient Sample

Stroke: Vascular and Interventional Neurology

JANUARY 29, 2024

The following article, published online on August 23, 2023 inStroke: Vascular and Interventional Neurology, has been retracted by mutual agreement between the authors and the journal Editors. Specifically, the variables for endovascular therapy and intravenous thrombolysis were mistakenly switched.

Inpatient

Inpatient Circulation Stroke Strokes

Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management

Stroke: Vascular and Interventional Neurology

AUGUST 16, 2023

To compile this narrative review, we conducted a systematic search of the PubMed database to identify relevant articles on the pathophysiological features and treatment of CRAO, including reviews, meta‐analyses, clinical studies, observational trials, and randomized trials. hours of symptom onset) results in better patient outcomes.

Article

Article Thrombolysis Risk Factors Ischemia

Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis

Stroke Journal

MARCH 11, 2024

Background:The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. Stroke, Ahead of Print. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0 or 1 at 90 days.

Stroke

Stroke Strokes Hemorrhage Thrombolysis

Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes

Stroke Journal

FEBRUARY 1, 2024

Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Results:9 articles were included from 825 screened. Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. to 1.64), ICH (unadjusted OR 1.32, 95% CI 0.79

Dementia

Dementia Outcomes Stroke Strokes

Outpatient vascular care : Good, bad or ugly?

Dr. Anish Koka

JULY 23, 2023

I’m sympathetic to Dr. Mustapha after reading the New York times article for a number of reasons. At the very least, the graphs make it highly unlikely that the main contention of the New York Times article - that higher rates of endovascular interventions leads to more amputations - is true.

Vascular Care

Vascular Care Outpatient Peripheral Arterial Disease Stents

If you had recorded an ECG during chest pain, what would it have shown?

Dr. Smith's ECG Blog

JUNE 28, 2018

12568 This is a validation of these 2 papers by Smith: [link] annemergmed.com/article/S0196- 0644(12)00160-6/pdf [link] jecgonline.com/article/S0022- 0736(17)30107-3/abstract This validation confirms that the 4-variable formula is very accurate and is better than the 3-variable formula! Am Heart J. 2000 Mar;139(3):430-6.

Chest Pain

Chest Pain Myocardial Infarction STEMI Article

Ballooning an obstructed prosthetic Aortic valve : Can be a real tense procedure!

Dr. S. Venkatesan MD

APRIL 10, 2024

A 76-year-old woman with a history of double valve replacement (Aortic and mitral valves) for rheumatic heart disease, presented with acute dyspnea after a switch from Warfarin to LMWH before a planned bone marrow biopsy. The investigations revealed a stuck aortic prosthetic valve ,that showed a prohibitive gradient of more than 50 mmhg.

Aortic valve

Aortic valve Aortic Thrombosis Bicuspid/Mitral

The “open data” movement runs aground on FOURIER

Dr. Anish Koka

JANUARY 18, 2023

The TIMI (Thrombolysis in Myocardial Infarction) Study Group is a Division of Cardiovascular Medicine at the esteemed Brigham and Women’s Hospital and Harvard Medical School. The article by Erviti et al. is fundamentally flawed, using incomplete data to reach incorrect conclusions.

Document

Document Academic Heart Attack Heart attacks

IV Thrombolysis + Thrombectomy vs. Thrombectomy Alone for Acute Ischemic Stroke

Large-Bore Mechanical Thrombectomy vs. Catheter-Directed Thrombolysis for Treatment of Intermediate-Risk Pulmonary Embolism

Multi-arm Optimization of Stroke Thrombolysis

Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillationâ€“Thrombolysis in Myocardial Infarction 48

Thrombolysis in Imaging-Eligible, Late-Window Patients to Assess the Efficacy and Safety of Tenecteplase

Retraction: Anterior Circulation Thrombectomy in Patients With Low National Institutes of Health Stroke Scale Score: Analysis of the National Inpatient Sample

Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management

Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis

Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes

Outpatient vascular care : Good, bad or ugly?

If you had recorded an ECG during chest pain, what would it have shown?

Ballooning an obstructed prosthetic Aortic valve : Can be a real tense procedure!

The “open data” movement runs aground on FOURIER

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