article thumbnail

IV Thrombolysis + Thrombectomy vs. Thrombectomy Alone for Acute Ischemic Stroke

American College of Cardiology

What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?

article thumbnail

Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48

American College of Cardiology

The ENGAGE AF-TIMI 48 trial sought to study the safety and efficacy of edoxaban, an oral direct factor Xa inhibitor, as compared with warfarin in the treatment of atrial fibrillation.

article thumbnail

Retraction: Anterior Circulation Thrombectomy in Patients With Low National Institutes of Health Stroke Scale Score: Analysis of the National Inpatient Sample

Stroke: Vascular and Interventional Neurology

The following article, published online on August 23, 2023 inStroke: Vascular and Interventional Neurology, has been retracted by mutual agreement between the authors and the journal Editors. Specifically, the variables for endovascular therapy and intravenous thrombolysis were mistakenly switched.

article thumbnail

Thrombolysis in Imaging-Eligible, Late-Window Patients to Assess the Efficacy and Safety of Tenecteplase

American College of Cardiology

The goal of the TIMELESS trial was to determine the efficacy and safety of tenecteplase administered between 4.5 and 24 hours after last known well time in patients with acute ischemic stroke and salvageable tissue on perfusion imaging.

article thumbnail

Central Retinal Artery Occlusion: A Review of Pathophysiological Features and Management

Stroke: Vascular and Interventional Neurology

To compile this narrative review, we conducted a systematic search of the PubMed database to identify relevant articles on the pathophysiological features and treatment of CRAO, including reviews, meta‐analyses, clinical studies, observational trials, and randomized trials. hours of symptom onset) results in better patient outcomes.

Article 40
article thumbnail

Intravenous Alteplase Versus Best Medical Therapy for Patients With Minor Stroke: A Systematic Review and Meta-Analysis

Stroke Journal

Background:The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. Stroke, Ahead of Print. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0 or 1 at 90 days.

Stroke 40
article thumbnail

Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes

Stroke Journal

Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Results:9 articles were included from 825 screened. Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. to 1.64), ICH (unadjusted OR 1.32, 95% CI 0.79