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This article explores the potential role of intracoronary thrombolysis, in conjunction with thrombus aspiration, in improving microcirculatory perfusion during PCI for STEMI patients. However, despite successful revascularization, microvascular obstruction (MVO) remains a major challenge, contributing to adverse clinical outcomes.
Introduction:Stroke is a leading cause of disability and mortality worldwide, with thrombolysis as a critical treatment. Studies aiming to assess the outcomes of thrombolysis after ischemic stroke in LMIC were selected. For the meta analysis, articles that included the administration of standard dose of 0.9
What is the association of treatment with intravenous thrombolysis (IVT) plus thrombectomy versus thrombectomy alone and outcomes modification by the time from stroke symptom onset to treatment?
The goal of the trial was to compare the efficacy and safety of large-bore mechanical thrombectomy (LBMT) with catheter-directed thrombolysis (CDT) in the treatment of intermediate-high risk pulmonary embolism (PE).
The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.
In the external set, patients with LVO treated with endovascular therapy achieving modified Thrombolysis in Cerebral Infarction score 2b and available baseline NCCT, CT angiography, and CT perfusion were included.RESULTSA total of 2858 studies of patients with stroke alerts were used for training (80%) and internal validation (20%).
The ENGAGE AF-TIMI 48 trial sought to study the safety and efficacy of edoxaban, an oral direct factor Xa inhibitor, as compared with warfarin in the treatment of atrial fibrillation.
The goal of the TIMELESS trial was to determine the efficacy and safety of tenecteplase administered between 4.5 and 24 hours after last known well time in patients with acute ischemic stroke and salvageable tissue on perfusion imaging.
The following article, published online on August 23, 2023 inStroke: Vascular and Interventional Neurology, has been retracted by mutual agreement between the authors and the journal Editors. Specifically, the variables for endovascular therapy and intravenous thrombolysis were mistakenly switched.
To compile this narrative review, we conducted a systematic search of the PubMed database to identify relevant articles on the pathophysiological features and treatment of CRAO, including reviews, meta‐analyses, clinical studies, observational trials, and randomized trials. hours of symptom onset) results in better patient outcomes.
Background:The efficacy of thrombolysis (IVT) in minor stroke (National Institutes of Health Stroke Scale score, 0–5) remains inconclusive. Stroke, Ahead of Print. The primary outcome was an excellent functional outcome, defined as a modified Rankin Scale score of 0 or 1 at 90 days.
Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Results:9 articles were included from 825 screened. Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. to 1.64), ICH (unadjusted OR 1.32, 95% CI 0.79
12568 This is a validation of these 2 papers by Smith: [link] annemergmed.com/article/S0196- 0644(12)00160-6/pdf [link] jecgonline.com/article/S0022- 0736(17)30107-3/abstract This validation confirms that the 4-variable formula is very accurate and is better than the 3-variable formula! Am Heart J. 2000 Mar;139(3):430-6.
A 76-year-old woman with a history of double valve replacement (Aortic and mitral valves) for rheumatic heart disease, presented with acute dyspnea after a switch from Warfarin to LMWH before a planned bone marrow biopsy. The investigations revealed a stuck aortic prosthetic valve ,that showed a prohibitive gradient of more than 50 mmhg.
I’m sympathetic to Dr. Mustapha after reading the New York times article for a number of reasons. At the very least, the graphs make it highly unlikely that the main contention of the New York Times article - that higher rates of endovascular interventions leads to more amputations - is true.
The TIMI (Thrombolysis in Myocardial Infarction) Study Group is a Division of Cardiovascular Medicine at the esteemed Brigham and Women’s Hospital and Harvard Medical School. The article by Erviti et al. is fundamentally flawed, using incomplete data to reach incorrect conclusions.
(We have done a study where we found thrombolysis was more effective in RCA apparently due to bi-modal continuous delivery of the lytic drugs, unlike the left system) Final message It is surprising why we are not recording intra-coronary pressure directly and trying to understand this.
We showed this in this article in JAMA Cardiology. REFERENCE Prevention of primary ventricular fibrillation in acute myocardial infarction with prophylactic lidocaine [link] Primary ventricular fibrillation (VF) during an acute myocardial infarction (AMI) occurs with a high incidence and mortality rate with or without thrombolysis.
See our article: Walsh, B., A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Since this is a young (30 years old!) patient, so it can't be acute MI, right? Macfarlane, P. Prutkin, J. and Smith, S. doi:10.1016/j.jelectrocard.2019.06.007)
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