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A significant proportion of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) have concomitant coronary artery disease (CAD). The best way to treat these patients is contentious.
This concept should be applied when managing older patients with severe aortic stenosis. Although left ventricular wall hypertrophy is expected in patients with aortic stenosis, it should not be assumed that this is caused only by aortic stenosis.
What is the relationship between aortic valve calcification (AVC) and aortic stenosis (AS) severity in patients with suspected low-flow low-gradient AS?
How does diffuse interstitial myocardial fibrosis, as observed on cardiac magnetic resonance (CMR), correlate with clinical outcomes in moderate and asymptomatic severe aortic stenosis (AS)?
The goal of the EARLY TAVR trial was to evaluate transcatheter aortic valve replacement (TAVR) compared with clinical surveillance among patients with asymptomatic severe aortic stenosis (stage C aortic stenosis).
The goal of the AVATAR trial was to evaluate aortic valve replacement (AVR) compared with conservative therapy among patients with asymptomatic severe aortic stenosis.
Articles were analyzed with bibliometric tools such as CiteSpace and VOSviewer to identify key research trends, core authors, institutions, and research hotspots in AI applications for AVS.ResultsA total of 118 articles were analyzed, showing a significant increase in publications from 2014 onwards.
In the article byTakajoetal, Mortality Patterns in Pediatric Pulmonary Vein Stenosis: Insights Into Right Ventricular Systolic Pressure Associations, which published online on January 17, 2025 (J Am Heart Assoc.2025;2025;14:e037908. Journal of the American Heart Association, Ahead of Print. 2025;2025;14:e037908. DOI:10.1161/JAHA.124.035037)
The EARLY TAVR trial results demonstrate that early transcatheter aortic valve implantation in patients with asymptomatic severe aortic stenosis is superior to clinical surveillance in significantly reducing the composite primary outcome of death, stroke, or unplanned hospitalization for cardiovascular causes.
In this week's View, Dr. Eagle looks at secular trends of incidence and outcomes in severe aortic stenosis. He then examines titration of medications after acute heart failure.
Which genetic and cardiovascular risk factors are aortic stenosis (AS)-specific, and which could be shared between AS and with coronary artery disease (CAD)?
Coronary angiography identified moderate stenosis of the right coronary artery (RCA), without significant flow restriction by invasive pressure wire interrogation. The patient presented with recurrent palpitations and pre-syncope, with no chest pain.
What are the hemodynamic and clinical outcomes after transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) among patients with severe aortic stenosis (AS) and a small aortic annulus?
A novel interactive, online decision aid used at the point of care among patients with severe aortic stenosis (AS) was strongly endorsed by patients and clinicians, easy to use and improved the quality of shared decision-making with a treatment decision that reflected patient values.
What are the clinical features and prognosis of patients with high-gradient (HG) aortic stenosis (AS) with a calculated aortic valve area (AVA) of >1.0
The NOTION trial, a pioneering study, sought to compare the long-term clinical and bioprosthesis outcomes of Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement (SAVR) in patients with severe aortic valve stenosis (AS) at lower surgical risk. Original article: Thyregod HGH et al.
A quantitative flow ratio (QFR)-guided strategy did not provide the same prognostic benefits as a fractional flow reserve (FFR)-guided strategy for patients with intermediate coronary stenosis, based on findings from the FAVOR III Europe trial presented at TCT 2024 and simultaneously published in The Lancet.
Herein, we review the management of acute heart failure caused by VHD with a focus on transcatheter therapies and describe currently available evidence based on a systematic literature search on the following valve pathologies: (i) aortic stenosis, (ii) aortic regurgitation, (iii) mitral regurgitation, and (iv) mitral stenosis.
In this review, authors discuss how multimodality imaging can help to evaluate the left ventricular remodeling response and improve risk stratification in patients with moderate aortic stenosis.
The goal of the DEDICATE-DZHK6 trial was to evaluate transcatheter aortic valve implantation (TAVI) compared with surgical aortic valve replacement (SAVR) among patients with severe aortic stenosis and low to intermediate surgical risk.
Is balloon angioplasty plus medical management superior to medical management alone in patients with symptomatic intracranial atherosclerotic stenosis?
Transcatheter aortic valve replacement (TAVR) is the standard treatment for severe aortic stenosis, but post-TAVR leaflet thrombus, identified by hypoattenuated leaflet thickening (HALT), poses potential risks like cerebral thromboembolic events. Original article: Choi Y et al. Perivalvular thrombus has also been reported.
Eagle looks at sacubitril/valsartan in patients hospitalized with decompensated heart failure, then examines the prevalence and outcomes of patients with discordant high gradient aortic stenosis.
The goal of the EVOLVED trial was to assess the safety and efficacy of early aortic valve replacement compared with conservative management among patients with asymptomatic severe aortic stenosis, normal ejection fraction (EF), and presence of myocardial fibrosis on cardiac magnetic resonance imaging (CMR).
What is the 5-year incidence of valve reintervention after self-expanding CoreValve/Evolut transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR)?
What is the change in incidence, clinical presentation, treatment, and outcome for quantitatively defined severe aortic stenosis (AS) over the last 20 years in a population-based community?
The goal of the PREVENT trial was to compare the safety and efficacy of medical therapy along with focal preventive PCI of non-flow-limiting vulnerable plaque compared with medical therapy alone.
Original article: Gaba P et al. Patients were stratified based on diabetes status, and various outcome measures were assessed using Kaplan-Meier event rates and Cox model hazard ratios. These findings underscore the importance of individualized treatment approaches in left main disease management. Circulation. 2024;149:00–00.
The goal of the VIVA trial was to evaluate transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (SAVR) among patients with severe aortic stenosis and a small aortic annulus.
He is the author of over 150 articles, book chapters, abstracts and other publications on advanced imaging technologies. and journal article authors Udo Hoffman, M.D., Earls is a founding member and one of the first Fellows of the Society of Cardiovascular CT. In Press European Heart Journal CV Imag 2024.This James Min, M.D.
The goal of the DEFINE-FLAIR trial was to evaluate if functional lesion assessment by instantaneous wave-free ratio (iFR) would be noninferior to fractional flow reserve (FFR) among patients with stable angina or acute coronary syndromes.
In these panel discussions, host Andrea Price, MS, AACC brings together Marian Hawkey, RN and Misty Theriot, BSN to explore best practices related to structural heart disease.
SGLT2 inhibitors may slow the progression of nonsevere aortic stenosis (AS), according to a study published Feb. 19 in JACC: Cardiovascular Interventions.
Transcatheter aortic valve replacement (TAVR) is a relatively new treatment method for aortic stenosis (AS) and has been demonstrated to be suitable for patients with varying risk levels.
The following are key points to remember from a review comparing the US and European guidelines for normal-flow low-gradient (NFLG) aortic stenosis (AS).
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