CONFIRM II: AI-QCT Assessment of Coronary Plaque Feature Confers Higher Relative Risk of MACE in Women
American College of Cardiology
MARCH 31, 2025
25 in Chicago and simultaneously published in Circulation: Cardiovascular Imaging.
Position Statement Expands Definition of High-Risk Plaque
American College of Cardiology
FEBRUARY 26, 2025
The definition of a high-risk plaque should be expanded beyond the traditional focus on plaque rupture and thin-cap fibroatheroma in the setting of acute coronary syndromes (ACS), according to a new JACC: Cardiovascular Imaging Position Statement.
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Calcium Burden, Vascular Inflammation, and Plaque Vulnerability
American College of Cardiology
SEPTEMBER 13, 2024
Is calcified plaque burden (CPB) associated with vascular inflammation and plaque vulnerability?
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High-Risk Plaques on Coronary CTA: Correlation With OCT
American College of Cardiology
APRIL 12, 2024
Are high-risk plaque (HRP) features on coronary computed tomography angiography (CTA) associated with vulnerable plaque on optical coherence tomography (OCT)?
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Coronary Atherosclerotic Plaque Activity and Risk of MI
American College of Cardiology
MAY 30, 2024
Is vessel-level coronary atherosclerotic plaque activity using coronary 18F-sodium fluoride positron emission tomography (PET) associated with patient vessel-level myocardial infarction (MI)?
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Preventive Coronary Intervention on Stenosis With Functionally Insignificant Vulnerable Plaque
American College of Cardiology
APRIL 8, 2024
The goal of the PREVENT trial was to compare the safety and efficacy of medical therapy along with focal preventive PCI of non-flow-limiting vulnerable plaque compared with medical therapy alone.
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Lp(a) and Coronary Plaque Progression
American College of Cardiology
JULY 24, 2024
What is the association of lipoprotein(a) (Lp[a]) levels with long-term coronary artery plaque progression, development of high-risk plaque, and pericoronary adipose tissue inflammation?
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58 Quantitative Coronary Plaque Analysis by Coronary Computed Tomography Angiography: Is it Ready For Primetime?
American College of Cardiology
NOVEMBER 20, 2024
A unique strength of coronary computed tomography angiography (CCTA) is the ability to noninvasively detect nonobstructive and obstructive coronary plaque.
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PREVENT: Preventive PCI Superior to Optimal Medical Therapy Alone to Reduce Cardiac Events From Vulnerable Plaques
American College of Cardiology
APRIL 8, 2024
PCI performed preventively in patients with high-risk vulnerable plaques was found to be superior to optimal medical therapy alone in preventing a serious cardiac event, according to the results of the PREVENT trial, the largest study on preventive PCI to date, presented during a Late-Breaking Clinical Trial session during ACC.24
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Plaque Burden, Morphology and Flow – Beyond the Lumen
American College of Cardiology
JUNE 18, 2024
Yancy, MD, MSc, MACC discuss insights from data and studies involving plaque burden, morphology and flow. In this interview, Andrew Choi, MD, FACC and Clyde W.
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Recurrent polymorphic ventricular tachycardia without chest pain: an unusual presentation of focal coronary artery spasm
The British Journal of Cardiology
MARCH 4, 2025
This case emphasises the importance of recognising plaque-associated CAS as a potential trigger for life-threatening arrhythmias, even in the absence of chest pain. The arrhythmias persisted despite initial medical management, including calcium channel blockers and intravenous glyceryl trinitrate.
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Atherosclerotic Plaque Erosion: Mechanisms, Clinical Implications, and potential therapeutic Strategies – a review
Journal of Cardiovascular Pharmacology
FEBRUARY 28, 2024
Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.
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Identification of M2 Macrophage-Related Key Genes in Advanced Atherosclerotic Plaques by Network Based Analysis
Journal of Cardiovascular Pharmacology
JANUARY 8, 2024
Atherosclerotic plaque accounts for major adverse cardiovascular events due to its vulnerability. The M1 and M2 macrophages are implicated in progression and regression of plaque, respectively. However, the therapeutic targets related M2 macrophages still remain largely elusive. or 0.001), respectively. All rights reserved.
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Letter by Kakizaki and Räber Regarding Article, “Effect of Colchicine on Coronary Plaque Stability in Acute Coronary Syndrome as Assessed by Optical Coherence Tomography: The COLOCT Randomized Clinical Trial”
Circulation
MARCH 30, 2025
Circulation, Volume 151, Issue 13 , Page e767-e768, April 1, 2025.
Article 45
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SBC Scientific Publication Award – 2024
International Journal of Cardiovascular Sciences
JULY 11, 2024
The Award will correspond to articles published in 2023. The Award will be given to the national authors of the best Original Article published in the journals ABC Cardiol, IJCS, ABC Imagem, and ABC HF in 2023. Awards granted: a) Plaque for each awarded article. b) Registration for the next subsequent congress.
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52 Response by Yu and Cheng to Letter Regarding Article, “Effect of Colchicine on Coronary Plaque Stability in Acute Coronary Syndrome as Assessed by Optical Coherence Tomography: The COLOCT Randomized Clinical Trial”
Circulation
MARCH 30, 2025
Circulation, Volume 151, Issue 13 , Page e769-e770, April 1, 2025.
Article 45
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SBC Scientific Publication Award
International Journal of Cardiovascular Sciences
JULY 18, 2023
The Award will refer to articles published in 2021 and 2022. The Award will be given to the Brazilian authors of the best Original Article published in the ABC Cardiol and IJCS journals for the years 2021 and 2022, and to Brazilian authors of the best Original Article published in the ABC Imagem and ABC HF journals in 2022.
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Is coronary dissection painful ?
Dr. S. Venkatesan MD
DECEMBER 2, 2023
This has important clinical significance , as many successfully lysed STEMI patient might have minimal segments of dissection/deep plaque fissures. , Image courtesy : An amazing learning resource by Charles Bruen, MD at [link] Reference A best review article on SCAD from NEJM Esther S.H. Is plaque fissure painful ?
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Association between the neutrophil-to-lymphocyte ratio and in-stent neoatherosclerosis and plaque vulnerability: An optical coherence tomography study
Journal of Cardiovascular Pharmacology
OCTOBER 9, 2024
Our study showed that an increased NLR was associated with ISNA and in-stent plaque fragility in patients with ISR following DES implantation. Our study showed that an increased NLR was associated with ISNA and in-stent plaque fragility in patients with ISR following DES implantation. Copyright © 2024 The Author(s).
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Results of CERTAIN Study Demonstrate Prominent Effects of Cleerly Products on Changing Clinical Management for Patients Suspected of Coronary Artery Disease
DAIC
FEBRUARY 13, 2024
He is the author of over 150 articles, book chapters, abstracts and other publications on advanced imaging technologies. and journal article authors Udo Hoffman, M.D., With Plaque Features Associated with False Positives. Earls is a founding member and one of the first Fellows of the Society of Cardiovascular CT. James Min, M.D.
Effects of the PCSK9 Antibody Alirocumab on Coronary Atherosclerosis in Patients With Acute Myocardial Infarction
American College of Cardiology
NOVEMBER 7, 2024
The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).
Wide Complex Tachycardia
EMS 12-Lead
AUGUST 18, 2024
I interpreted the ECG as VT with two primary etiological possibilities: 1. Abrupt plaque ulceration of Type 1 ACS leading to VT. link] [link] Here’s a recent article from the JACC that not only summarizes previous WCT ECG research (eg, Brugada, Vereckei, etc), but presents a novel algorithm that may perform better.
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Coronary Artery Calcium Density and Risk of CV Events
American College of Cardiology
SEPTEMBER 19, 2024
Is coronary artery calcium (CAC) density by computed tomography (CT) inversely associated with plaque vulnerability and atherosclerotic cardiovascular disease (ASCVD) events (coronary heart disease [CHD] and stroke)?
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Feature | Rethinking the Meaning of IHD: Invasive Assessment of ANOCA
American College of Cardiology
FEBRUARY 2, 2024
Typically, ischemia is associated with epicardial coronary artery obstruction caused by atherosclerotic plaque. Ischemic cardiovascular disease (IHD) continues to be a significant public health problem in the U.S.
Upon arrival to the emergency department, a senior emergency physician looked at the ECG and said "Nothing too exciting."
Dr. Smith's ECG Blog
NOVEMBER 30, 2022
In a recent article (J Electrocardiol this year, see reference below), peak trop onin I levels in takotsubo presenting with ST Elevation were median 1.02 Note 2: This article fails to specify whether it was troponin I or T, but I contacted the institution and they used exclusively troponin I during that time period.
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1 hour of CPR, then ECMO circulation, then successful defibrillation.
Dr. Smith's ECG Blog
MAY 19, 2020
If the arrest was caused by acute MI due to plaque rupture, then the diagnosis is MINOCA. Here is my comment on MINOCA: "Non-obstructive coronary disease" does not necessarily imply "no plaque rupture with thrombus." They often cannot even be recognized as culprits, as fissured or ulcerated plaque. FFR can be useful.
HDAC9 Inhibition as a Novel Treatment for Stroke
Stroke Journal
NOVEMBER 9, 2023
This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease.
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40 A new paper by me – please share widely
Dr. Malcolm Kendrick
AUGUST 26, 2022
26th August 2022 And so, after a great deal of faffing about, my article on cardiovascular disease ‘Assessing cardiovascular disease: looking beyond cholesterol’ has been made free to view. Writing an article for a medical journal is not that difficult. As for allowing the article to be open access … don’t go there.
Naturally Occurring Atherosclerosis Progression and In-Stent Restenosis: Exploring Histomorphological Associations Using Optical Coherence Tomography
Journal of Cardiovascular Pharmacology
NOVEMBER 26, 2023
A significantly higher proportion of patients in the ISR with non-target lesion progression (N-TLP) group exhibited lipid plaque formation compared to the ISR without N-TLP group (69.0% The mechanism of ISR was emamined through qualitative and quantitative analysis of OCT imaging. versus 39.8%, P < 0.001). versus 39.8%, P < 0.001).
An athletic 30-something woman with acute substernal chest pressure
Dr. Smith's ECG Blog
JULY 31, 2018
Post by Smith, with short article by Angie Lobo ( [link] ), a third year intermal medicine resident at Abbott Northwestern Hospital Case A 30-something woman with no past history, who is very fit and athletic, presented with 1.5 hours of substernal chest pressure. It was non-radiating and without other associated symptoms except for nausea.
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Vessel-Level Coronary Atherosclerotic Plaque Activity Predicts Myocardial Infarction Risk
Cardiology Update
JUNE 16, 2024
Recent research has illuminated the role of total coronary atherosclerotic plaque activity across the entire coronary arterial tree in predicting patient-level clinical outcomes. Vessel-level coronary atherosclerotic plaque activity was assessed using coronary 18 F-sodium fluoride positron emission tomography (PET). 3.72; P = 0.013).
ECG with Aslanger's Pattern. CT Pulmonary Angiogram Reveals LAD Ischemia (Septal Transmural). But this is not Contradictory.
Dr. Smith's ECG Blog
JANUARY 4, 2021
Aslanger added in the limitations in his article: " Theoretically, an isolated basal inferoseptal infarction or an acute inferior MI in the presence of previous infarctions that may change the orientation of lesion vector can also cause a similar picture. Could this be Septal STEMI (STE in V1 and aVR, with reciprocal ST depression in V4-V6?),
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The Advantages Of A CT Coronary Angiogram
Dr. Paddy Barrett
AUGUST 1, 2023
This article is part 2 of a series on cardiac CT. If you have not yet read it, I suggest doing so before reading the remainder of this article. I've included the article here. A CTCA provides much more anatomical detail and can identify advanced plaque often missed by CT Coronary Artery Calcium Score scans alone.
10 Things You Can Do To Improve Your Heart Health
Dr. Paddy Barrett
MAY 3, 2024
I have now written over 110 articles, and my initial nine newsletter subscribers have grown to over 20,000. But while each article provides a lot of value, many of you have asked if I would write a book that provides a simple, sequential series of content explaining heart disease and how to reduce risk. 33 years of age.
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The Latest Evidence on Atherosclerosis in Athletes
Physiologically Speaking
APRIL 10, 2024
people from the general population), coronary artery calcium scores (CACS) are higher, indicating more calcification and the presence of atherosclerotic plaques. Calcified plaques are known to be more stable and less prone to rupture and lead to a heart attack. When comparing athletes to control groups (i.e., hours per week).
Beating the Odds: Inside the Tribe with a Near-Zero Rate of Heart Disease.
Dr. Paddy Barrett
JANUARY 23, 2024
However, most adults will start to develop advanced plaque in their coronary arteries early in life. By age 66, more than half of all females will have evidence of advanced plaque in their coronary arteries, as seen on a CT calcium score. Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque.
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What To Do If You Have An Early Family History Of Heart Disease
Dr. Paddy Barrett
JUNE 21, 2024
Therefore, if someone presents with an event earlier than this age, they likely have been building up plaque for a considerable period prior to this. If you don’t know what those are, I suggest you go back to the many prior articles I have written on the topic) But let’s assume you have these down. What do you do next?
What is Takotsubo Cardiomyopathy (Broken Heart Syndrome)?
BoardVitals - Cardiovascular
FEBRUARY 10, 2020
You can find the answer and explanation at the end of this article. Before I explain what exactly takotsubo cardiomyopathy is, see if you can answer this BoardVitals cardiology board review question. Cardiology Board Review Question A 48-year-old female with no known medical history presents with acute substernal chest pain.
Do You Need A Stent To Treat Your Heart Disease?
Dr. Paddy Barrett
NOVEMBER 28, 2023
Arteries generally narrow and occlude for one of two reasons: The progressive accumulation of plaque. A plaque ruptures, and a clot forms in the artery, thereby occluding it. There are the ‘garden variety’ heart attacks whereby a plaque ruptures in the coronary artery, called a spontaneous heart attack.
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Noisy, low amplitude ECG in a patient with chest pain
Dr. Smith's ECG Blog
JANUARY 15, 2024
As an aside, the LCx OMI is a type 2 event, since it is due to supply-demand mismatch from thrombus, and not due to atherosclerotic plaque rupture or erosion). The September 27, 2019 post — for the Rowlands & Moore article with the above-noted formulas for recognizing the “culprit” extremity. The November 10, 2020 post — for PTA.
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64 A 40-Something male with a "Seizure," Hypotension, and Bradycardia
Dr. Smith's ECG Blog
OCTOBER 7, 2019
Here is full text of this article. He was taken to the cath lab and underwent emergent intervention: Thrombotic stenosis of the proximal RCA (95% with evidence of plaque rupture) is the culprit for the patient's inferoposterior STEMI. Case continued EMS immediately transported, activated the cath lab and gave 324 mg aspirin en route.
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If you have High LDL Cholesterol In Midlife This Is How You Should Think About It.
Dr. Paddy Barrett
JULY 12, 2024
If you have high LDL cholesterol and are unsure what that means for your risk of heart disease, this article is for you. A higher cumulative LDL cholesterol exposure equals a higher likelihood of plaque in the coronary arteries, known as atherosclerosis. But the more plaque you have, the higher the risk of a heart attack.
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Wrong lessons in lipidology : Eradicating LDL is not our goal !
Dr. S. Venkatesan MD
JANUARY 8, 2024
While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear. LDL is obviously a target against atherosclerosis. Mind you LDL constitutes.000025% 000025% of total fat. Let us use it maximum.
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Study Confirms Positive Long-Term Outcomes Using AI-enabled FFRCT and Plaque Analysis
DAIC
OCTOBER 30, 2024
Data confirm the use of FFR CT and Plaque Analysis helps assess long-term risks, informing more personalized and effective treatment plans for patients with coronary artery disease. The prospective data with long-term follow-up in ADVANCE-DK alongside Plaque Analysis data gave us far more than that. 27, 2024 — HeartFlow, Inc.
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