American College of Cardiology

MARCH 19, 2024

Noel Bairey Merz, MD, FACC, and Vera Bittner, MD, MSPH, FACC, discuss Low-Density Lipoprotein Cholesterol Testing Following MI Hospitalization Among Medicare Beneficiaries. In this interview, C.

Medicare 53

Medicare Cholesterol Hospital Article 53

Dr. Paddy Barrett

AUGUST 9, 2024

The 14 Factors Include: Hearing Loss High LDL cholesterol Less Education Traumatic Brain Injury Depression Social Isolation Hypertension Obesity Smoking Excess Alcohol Diabetes Physical Inactivity Air Pollution Visual Loss Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission When You Intervene Matters.

Dementia 115

Dementia Blood Pressure Obesity Cholesterol 115

Dr. Paddy Barrett

MAY 3, 2024

What is a normal cholesterol? I have now written over 110 articles, and my initial nine newsletter subscribers have grown to over 20,000. It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. What should my blood pressure be? No symptoms.

Heart Attack 104

Heart Attack Heart attacks Blood Pressure Risk Factors 104

Dr. Paddy Barrett

APRIL 4, 2025

Do you use advanced cholesterol testing? Remember, after reading all my newsletter articles, you will have an excellent idea of how to do this. This is all about understanding whether a 'risk factor,’ e.g. High LDL-C cholesterol, has translated into significant ‘disease,’ e.g. coronary artery disease.

Blood Pressure 84

Blood Pressure Exercise Heart Disease Cholesterol 84

American College of Cardiology

JANUARY 22, 2024

The goal of the CLEAR Outcomes trial was to evaluate bempedoic acid compared with placebo among statin-intolerant patients.

Cholesterol 63

Cholesterol Outcomes Article 63

Dr. Paddy Barrett

MAY 25, 2024

He doesn't read every article but reads most of them. What lifestyle measures should he use to lower his LDL cholesterol and reduce his blood pressure? I met a friend of mine from the Middle East a few weeks ago. He has been reading this newsletter for over a year. He said he loves it. He’s busy. We all are.

Heart Disease 90

Heart Disease Blood Pressure Cholesterol Article 90

Cardiometabolic Health Congress

AUGUST 23, 2024

Newly included risk factors— untreated vision loss and high LDL cholesterol —underscore the critical role of these elements in maintaining cognitive health. The Cholesterol Connection Cholesterol’s recognition as a risk factor for dementia marks a pivotal advancement in understanding, preventing, and delaying cognitive decline.

Dementia 52

Dementia Cholesterol Risk Factors CME 52

Dr. Paddy Barrett

APRIL 26, 2024

Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. But if a retained cholesterol particle is the spark. A future article will discuss how to reverse type 2 diabetes but I want to look at the impact of how getting multiple smaller factors right can make a big difference to future life span.

Heart Disease 105

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 105

DAIC

JANUARY 4, 2024

Patients were randomly assigned to one of two protocol groups, with 100 patients allowed to eat a specified diet of solid food low in fat, cholesterol, sodium and acidity until the scheduled procedure. To access the article and full-text PDF, visit the AJCC website at www.ajcconline.org.

Diet 105

Diet Critical Care Inpatient Nursing 105

Dr. Paddy Barrett

MAY 18, 2024

But with over 100 articles, it can be hard to piece it all together though. Lower LDL cholesterol levels. When people ask me what they should read to better understand what tests to take and what steps they need to do to reduce their risk of heart disease, I point them to this newsletter. It can feel overwhelming. Lower blood pressure.

Heart Disease 82

Heart Disease Blood Pressure Cholesterol Article 82

American College of Cardiology

APRIL 1, 2025

Mixed dyslipidemia is characterized by elevated concentrations of circulating triglycerides and low-density lipoprotein cholesterol [LDL-C]).

Cholesterol 67

Cholesterol Circulation Article 67

American College of Cardiology

MAY 20, 2024

Does apolipoprotein B (apoB) have a utility in atherosclerotic cardiovascular disease (ASCVD) or are low-density lipoprotein cholesterol (LDL-C), non–high-density lipoprotein cholesterol (non–HDL-C), and triglycerides sufficient for routine cardiovascular (CV) care?

Cholesterol 61

Cholesterol Cardiovascular Disease Article 61

Dr. Paddy Barrett

JUNE 21, 2024

He had high blood pressure and high cholesterol most of his life, and he wasn’t great at taking his tablets.” If you don’t know what those are, I suggest you go back to the many prior articles I have written on the topic) But let’s assume you have these down. “Dad had a heart attack at 78.

Heart Disease 82

Heart Disease Heart Attack Heart attacks Coronary Artery Disease 82

American College of Cardiology

OCTOBER 23, 2024

In this week’s View, Dr. Eagle looks at anthracycline cardiotoxicity in treatment of cancer patients.

COVID-19 56

COVID-19 Cancer Cholesterol Arrhythmia 56

American College of Cardiology

JULY 2, 2024

Does the relationship between low-density lipoprotein cholesterol (LDL-C) lowering and cardiovascular (CV) benefit achieved with bempedoic acid resemble that observed with statins when standardized per unit change in LDL-C?

Cholesterol 64

Cholesterol Article 64

Dr. Paddy Barrett

NOVEMBER 7, 2023

The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. Each of these particles contains varying amounts of LDL cholesterol (CE) and triglycerides INSIDE the particle. CE = Cholesterol Ester. Share But what about LDL cholesterol? TG = Triglycerides.

Cholesterol 52

Cholesterol Atherosclerosis Stenosis Aortic 52

American College of Cardiology

JULY 15, 2024

The goal of the EVOLVD trial was to demonstrate the efficacy of evolocumab on coronary intimal thickness in heart transplant recipients.

Heart Transplant 50

Heart Transplant Transplant Cholesterol Article 50

Dr. S. Venkatesan MD

JANUARY 8, 2024

10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear.

Cholesterol 52

Cholesterol Atherosclerosis Plaque Physiology 52

Dr. Paddy Barrett

SEPTEMBER 19, 2023

Share If you do not read any further, you will have come away with the main takeaway of this article. I do apologise for being direct, but this issue is one of the most frequent barriers I encounter to initiating cholesterol-lowering therapy. At the exact same time, cholesterol concentrations are also at their lowest.

Dementia 52

Dementia Cholesterol Biomarkers Coronary Artery Disease 52

Dr. Malcolm Kendrick

AUGUST 26, 2022

26th August 2022 And so, after a great deal of faffing about, my article on cardiovascular disease ‘Assessing cardiovascular disease: looking beyond cholesterol’ has been made free to view. Writing an article for a medical journal is not that difficult. As for allowing the article to be open access … don’t go there.

Cardiovascular Disease 40

Cardiovascular Disease Cholesterol Article Plaque 40

American College of Cardiology

FEBRUARY 2, 2024

The goal of the ORION-5 trial was to assess the safety and efficacy of inclisiran in lowering low-density lipoprotein cholesterol (LDL-C) among patients with homozygous familial hypercholesterolemia (HoFH).

Cholesterol 60

Cholesterol Article 60

DAIC

FEBRUARY 1, 2024

The article also includes links to DAIC channels (on peripheral artery disease, stroke, heart failure, peripheral artery disease, cardiovascular clinical studies, and more) focused on specific areas of news coverage.

Cardiovascular Disease 104

Cardiovascular Disease Atherosclerosis Stroke Strokes 104

Dr. S. Venkatesan MD

JANUARY 21, 2024

Article will be linked) We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. This is the much famous Reverse Cholesterol Transport(RCT) and the anti-atherosclerotic effect of HDL.It is expected to change its shape like a chameleon, while ferrying the cholesterol to liver.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

American College of Cardiology

JULY 3, 2024

How do low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) [Lp(a)-C] levels compare in their association with incident coronary heart disease (CHD) in a general population?

Cholesterol 53

Cholesterol Heart Disease Article 53

Cardiology Update

JANUARY 24, 2024

Metabolic risks, including high systolic blood pressure, high LDL cholesterol, high BMI, high fasting plasma glucose, and kidney dysfunction, contribute substantially to age-standardized CVD disability-adjusted life years (DALYs). Original article: Mensah GA et al. J Am Coll Cardiol. 2023 Dec, 82 (25) 2343–2349.

Cardiovascular Disease 119

Cardiovascular Disease Research Blood Pressure Public Health 119

Dr. Paddy Barrett

AUGUST 22, 2023

A subsequent article will focus on the risk of late-onset dementia for those carriers of APOE4. Every lipoprotein particle has one APO B protein. ( **Please note the B ) When we measure APO B levels, this is what we are measuring to give an estimate of the number of cholesterol particles and the subsequent risk of cardiovascular disease.

Cholesterol 52

Cholesterol Dementia Coronary Artery Disease Cardiovascular Disease 52

Dr. Paddy Barrett

MAY 17, 2024

The short answer is ‘ Yes ’ But if you want to know why and what you can do about it, you should read the rest of this article. When stress is included in the risk factor profile for a future heart attack, it comes in third on the list after abnormal cholesterol and smoking 1. Does stress cause heart disease?

Heart Disease 101

Heart Disease Heart attacks Heart Attack Risk Factors 101

American College of Cardiology

SEPTEMBER 23, 2024

Familial hypercholesterolemia (FH), characterized by lifelong elevations in low-density lipoprotein cholesterol (LDL-C), is the most common autosomal-dominant genetic disorder in the world.

Coronary Artery Disease 56

Coronary Artery Disease Cholesterol Article 56

American College of Cardiology

NOVEMBER 13, 2024

What is the relationship between lipoprotein(a) [Lp(a)] levels, low-density lipoprotein cholesterol (LDL-C) levels, and atherosclerotic cardiovascular disease (ASCVD) risk at different thresholds?

Cholesterol 50

Cholesterol Cardiovascular Disease Article 50

European Journal of Heart Failure

JANUARY 21, 2025

The (+) and () signs mean that the variable has a positive or a negative association with growth differentiation factor-15 (GDF-15) levels in the fully adjusted model (age, gender, current smoker, body mass index, total cholesterol, systolic blood pressure and N-terminal pro-B-type natriuretic peptide), respectively.

Circulation 40

Circulation Blood Pressure Cholesterol Research 40

American College of Cardiology

AUGUST 31, 2024

How do high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) [Lp(a)] levels predict cardiovascular (CV) risk over decades of time in women?

Cholesterol 50

Cholesterol Outcomes Article 50

Dr. Paddy Barrett

JANUARY 23, 2024

As a side note, many Blue Zones are thought to be more a function of falsified or improper record keeping, but that’s an article for another day). The average Non-HDL cholesterol for western populations is 3.6 The average Non-HDL cholesterol is 2.9 Tsimane Tribe. mmol/l (112 mg/dl), which equates to the 20th percentile.

Heart Disease 105

Heart Disease Blood Pressure Dementia Atherosclerosis 105

American College of Cardiology

OCTOBER 21, 2024

What is the relationship between non–high-density lipoprotein cholesterol (non–HDL-C) levels after myocardial infarction (MI) and risk of adverse outcomes?

Myocardial Infarction 45

Myocardial Infarction Cholesterol Outcomes Article 45

Stroke Journal

NOVEMBER 9, 2023

This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease.

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

Stroke Journal

JANUARY 30, 2025

The SPARCL (Stroke Prevention by Aggressive Reduction of Cholesterol Level) study amongst others, have suggested that statin use may increase risk of ICH in those with prior history ICH, due to increased erythrocyte fragility and inhibition of platelet aggregation. Roughly 20-30% of patients with ICH take a statin at the time of ICH onset.

Hemorrhage 40

Hemorrhage Cholesterol Biomarkers Article 40

Dr. Paddy Barrett

AUGUST 1, 2023

This article is part 2 of a series on cardiac CT. If you have not yet read it, I suggest doing so before reading the remainder of this article. I've included the article here. Part one explored the utility and benefits of CT Calcium Scoring. Share But why do a CT if risk factor modification is the priority?

Coronary Angiogram 52

Coronary Angiogram Plaque Coronary Artery Disease Chest Pain 52

Dr. Paddy Barrett

JANUARY 24, 2025

In addition to this very aggressive calorie restriction, patients also consumed very little fat, protein, cholesterol, or salt. But as I said at the outset of this article. Would You Like To Attend The Cholesterol Secrets Masterclass? The answer is a calorie restriction of about 400 - 800 Kcal per day. They exercised daily.

Diet 52

Diet Obesity Diabetes Cholesterol 52