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EFFECTS OF PTEROSTILBENE ON HEART AND LUNG OXIDATIVE STRESS PARAMETERS IN TWO EXPERIMENTAL MODELS OF CARDIOVASCULAR DISEASE: MYOCARDIAL INFARCTION AND PULMONARY ARTERIAL HYPERTENSION

Journal of Cardiovascular Pharmacology

Myocardial infarction (MI) and pulmonary artery hypertension (PAH) are two prevalent cardiovascular diseases. This study aims to evaluate the effect of PTE on oxidative stress in the hearts of animals with myocardial infarction and in the lungs of animals with PAH. Male Wistar rats were used in both models.

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ALKBH5 regulates N(6)-methyladenosine (m6A) methylation of MG53 to attenuate myocardial infarction by inhibiting apoptosis and oxidative stress

Journal of Cardiovascular Pharmacology

Abstract: N(6)-methyladenosine (m6A) methylation modification is involved in the progression of myocardial infarction (MI). Overexpression of ALKBH5 inhibited H/R-induced cardiomyocyte apoptosis and oxidative stress in vitro, and inhibited I/R-induced collagen deposition, cardiac function, and apoptosis in vivo.

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Protective Effect of CD137 Deficiency against Post-infarction Cardiac Fibrosis and Adverse Cardiac Remodeling via ERK1/2 Signaling Pathways

Journal of Cardiovascular Pharmacology

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. The specific role of CD137 in the development of post-MI myocardial fibrosis remains unclear. Copyright © 2024 Wolters Kluwer Health, Inc.

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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

Troponin T peaked at 38,398 ng/L ( = a very large myocardial infarction, but not massive-- thanks to the pre-PCI spontaneous reperfusion, and rapid internvention!! ). Cardiac function is poor, with akinesis of the LAD territory. Inotropic medication was continued.

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Cardiac resynchronization therapy (CRT) – why is it so important?

Cardiomatics

This results in a deficiency of oxygen and nutrients in the cells of the body, which can have a huge impact on how it functions. Moreover, the improvement of care for patients with myocardial infarction has resulted in higher survival rates, but as a result, more patients suffer from heart failure.