article thumbnail

NT-proBNP and Troponin I in Cardiac Function

American College of Cardiology

How do N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-CTnI) predict long-term changes in cardiac structure and function in older adults?

article thumbnail

Engineered exosomes: a potential therapeutic strategy for septic cardiomyopathy

Frontiers in Cardiovascular Medicine

This article examines the strategies for using engineered exosomes to protect cardiac function and treat septic cardiomyopathy. The article highlights the ability of exosomes to deliver small molecules, proteins, and drugs, summarizing several RNA molecules, proteins, and drugs beneficial for treating septic cardiomyopathy.

article thumbnail

Coagulation Factor XI Level and Cardiac Events and Function

American College of Cardiology

Are plasma factor XI levels associated with cardiovascular events and cardiac function in humans?

article thumbnail

Top Stories: Mitochondrial origin of inherited cardiac arrhythmias

HeartRhythm

Mitochondria control cardiac function by regulating adenosine triphosphate synthesis, reactive oxygen species (ROS) generation, intracellular calcium (Ca2+), and the cellular redox state. Yet, their role in the pathophysiology of arrhythmias remains massively underappreciated.

article thumbnail

Canonical Transient Receptor Potential (TRPC) Channels in Cardiovascular Pathology and their Modulators

Journal of Cardiovascular Pharmacology

Ion channels play a crucial role in various aspects of cardiac function, such as regulating rhythm and contractility. Cell function is substantially influenced by the concentration of free cytosolic calcium (Ca2+) and the voltage across the plasma membrane.

article thumbnail

A potential research target for cardiac rehabilitation: brain-derived neurotrophic factor

Frontiers in Cardiovascular Medicine

Improvements in exercise tolerance, lipid metabolism, cardiac function, and psychological aspects of the patients were evident with appropriate exercise interventions based on a comprehensive assessment. Aerobic exercise, resistance training, flexibility training, and other forms of exercise are recommended by many experts.

article thumbnail

Protective Effect of CD137 Deficiency against Post-infarction Cardiac Fibrosis and Adverse Cardiac Remodeling via ERK1/2 Signaling Pathways

Journal of Cardiovascular Pharmacology

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared to wild-type mice at day 28 post-MI.