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Engineered exosomes: a potential therapeutic strategy for septic cardiomyopathy

Frontiers in Cardiovascular Medicine

This article examines the strategies for using engineered exosomes to protect cardiac function and treat septic cardiomyopathy. The article highlights the ability of exosomes to deliver small molecules, proteins, and drugs, summarizing several RNA molecules, proteins, and drugs beneficial for treating septic cardiomyopathy.

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Top Stories: Mitochondrial origin of inherited cardiac arrhythmias

HeartRhythm

Mitochondria control cardiac function by regulating adenosine triphosphate synthesis, reactive oxygen species (ROS) generation, intracellular calcium (Ca2+), and the cellular redox state. Yet, their role in the pathophysiology of arrhythmias remains massively underappreciated.

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A potential research target for cardiac rehabilitation: brain-derived neurotrophic factor

Frontiers in Cardiovascular Medicine

Improvements in exercise tolerance, lipid metabolism, cardiac function, and psychological aspects of the patients were evident with appropriate exercise interventions based on a comprehensive assessment. Aerobic exercise, resistance training, flexibility training, and other forms of exercise are recommended by many experts.

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Protective Effect of CD137 Deficiency against Post-infarction Cardiac Fibrosis and Adverse Cardiac Remodeling via ERK1/2 Signaling Pathways

Journal of Cardiovascular Pharmacology

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared to wild-type mice at day 28 post-MI.

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Canagliflozin mediates mitophagy through the AMPK/PINK1/PARKIN pathway to alleviate isoprenaline-induced cardiac remodelling

Journal of Cardiovascular Pharmacology

Furthermore, the differential expression of AMPK/PINK1/Parkin pathway-related proteins in ISO-induced cardiac remodeling was effectively reversed by canagliflozin, suggesting the therapeutic potential of targeting this pathway with the drug. Heart failure has always been a prevalent, disabling, and potentially life-threatening disease.

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Transcriptome Analysis Reveals Enhancement of Cardiogenesis-Related Signaling Pathways by S-nitroso-N-pivaloyl-D-penicillamine (SNPiP): Implications for Improved Diastolic Function and Cardiac Performance

Journal of Cardiovascular Pharmacology

Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function.

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The protective effects of ruscogenin against lipopolysaccharide-induced myocardial injury in septic mice

Journal of Cardiovascular Pharmacology

We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice. We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice.