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BackgroundInflammation, as the basic pathogenic mechanism of atherosclerosis, promotes the development of atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD). Two reviewers independently screened articles and extracted data. Meta-analysis was performed using RevMan 5.4
Chronic inflammation plays a role in the pathogenesis of cardiovascular diseases, including atherosclerosis, pericarditis, stroke, and myocardial infarction (MI).
Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?
Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy.
BackgroundWhile Traditional Chinese Medicine (TCM) boasts an extensive historical lineage and abundant clinical expertise in addressing atherosclerosis, this field is yet to be penetrated adequately by bibliometric studies. The Journal of Ethnopharmacology leads with the most publications and boasts the greatest total number of citations.
Nearly 80% of patients with lung cancer had detectable atherosclerosis on their cancer staging CT scans and other cardiovascular risk factors were common, offering an opportunity for earlier cardiac testing and risk factor modification, according to a new study.
So far, researchers have focused on the significance of silicon for the development of bones and connective tissue, and its role in preventing neurodegenerative diseases and atherosclerosis. Despite numerous studies, the role of silicon as an active element in the human body is poorly understood.
He is the author of over 150 articles, book chapters, abstracts and other publications on advanced imaging technologies. and journal article authors Udo Hoffman, M.D., 25, 2024 in the European Heart Journal Cardiovascular Imaging 1. Earls is a founding member and one of the first Fellows of the Society of Cardiovascular CT.
This modification will affect not only the onset of diabetes but also the related onset of atherosclerosis. Therefore, in this review, based on the whole process of atherosclerosis evolution, we explored the possible existence of acetylation/deacetylation caused by diabetes.
In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease.
Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated. Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated.
According to a new study published in JACC, there is a strong dose-response relationship between cigarette smoking and three different domains of subclinical cardiovascular markers: inflammation, thrombosis and subclinical atherosclerosis.
The goal of the INSPIRES trial was to determine whether DAPT with clopidogrel and aspirin initiated within 72 hours of mild ischemic stroke or high-risk TIA was associated with decreased incidence of recurrent stroke compared with aspirin monotherapy.
However, due to the distinct biological functions of ASCs from different origins or donors with varing health statuses (such as aging, diabetes, or atherosclerosis), the heterogeneity of ASCs deserves more attention. Exosomes from ASCs also play an indispensable role in this process.
The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).
In this week’s View, Dr. Eagle looks at the clinical impact of early rhythm control and healthy lifestyles in patients with atrial fibrillation, then explores the use of low-dose aspirin in the prevention of atherosclerotic cardiovascular disease.
The risk of atherosclerotic cardiovascular disease (ASCVD) is approximately twofold higher for South Asian (SA) adults than for adults from other racial and ethnic groups. Type 2 diabetes mellitus (T2DM) is a highly prevalent risk factor that likely contributes to this disparity.
The use of noncigarette tobacco products is associated with considerable cardiovascular risk, as demonstrated by relevant inflammation, thrombosis and atherosclerosis markers, according to a cross-sectional study published Jan.
CiteSpace was used to analyze author and institution centroids, keyword bursts, and timeline graphs.ResultA total of 2,474 articles related to CVD and PCSK9 were included. The number of articles and citations show an increasing trend from year to year. Atherosclerosis was the most published journal. Watts, Gerald F.
Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.
In this article, we first describe how ERK signaling contributes to preserving cardiovascular health. We then summarize current knowledge of the roles played by ERK in the development and progression of cardiac and vascular disorders, including atherosclerosis, myocardial infarction, cardiac hypertrophy, heart failure, and aortic aneurysm.
Immune-mediated systemic inflammatory disorders (IMIDs) are associated with an increased risk of cardiovascular disease (CVD), ranging from atherosclerosis to myocarditis and heart failure.
This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease. Indirect data support such an approach in man.
The pooled mean percentage difference between the cardioembolic group and the large artery atherosclerosis /noncardioembolic group was 10.3% (95% CI 16.3% Of these, the pooled percentage difference of white blood cells between the cardioembolic group and the large artery atherosclerosis/noncardioembolic group was +1.1% (95% CI +0.3%
Thicker carotid intima–media thickness (CIMT) has been a valid predictor for atherosclerosis development. Reference lists of retrieved articles were further scanned as to avoid any missing literatures. 331 articles were retrieved, and 4 were finally selected.
The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. It is the inflammatory response to this particle retention that causes the formation of atherosclerosis 1. Lipoprotein particles entering the subintimal space causing atherosclerosis. CE = Cholesterol Ester.
Explore the CMHC Lipid Management Hub Visit the CMHC Lipid Management Hub , where you’ll find a wealth of resources, including webinars, CME activities, expert interviews, on-demand event recordings, news articles, drug pipelines, and more, all organized by specialty focus and format.
cobalt, copper, zinc) are associated with increased coronary artery calcification (CAC) and are comparable to traditional cardiovascular disease risk factors like smoking and diabetes, according to results from the Multi-Ethnic Study of Atherosclerosis (MESA) published in JACC. Urinary levels of non-essential (i.e.,
We included articles reporting patients > 18 years old with symptomatic extracranial vertebral artery stenoses due to atherosclerosis treated with stenting (with or without angioplasty). Those reporting patients with vertebral dissections were excluded.
In this week’s View, Dr. Eagle looks at a systematic review and meta-analysis of antibiotic prophylaxis and infective endocarditis incidence following invasive dental procedures. He then examines the issue of serious bleeding in patients with atrial fibrillation using diltiazem with apixaban or rivaroxaban.
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We conducted analysis on the determinants of high-risk coronary calcification, represented by CAC score, among women as a step to improve their outcomes and prognosis.
ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; GRAM, GRaph-based Attention Model; PCP-HF, Pooled Cohort equations to Prevent Heart Failure; RETAIN, REverse Time AttentIoN model. Risk of bias was assessed using PROBAST. We included 36 studies with 59 prediction models.
Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. In this study, we developed and validated a machine learning-based clustering approach to identify the high-risk DbCM phenotype based on echocardiographic and cardiac biomarker parameters.
A subsequent article will focus on the risk of late-onset dementia for those carriers of APOE4. Share For those with defective LDL receptors, as seen in familial hyperlipidemia, APOB particles are not cleared effectively, and concentrations rise, causing atherosclerosis 4. Which increases the risk of atherosclerosis.
Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation.
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