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Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?
Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy.
BackgroundWhile Traditional Chinese Medicine (TCM) boasts an extensive historical lineage and abundant clinical expertise in addressing atherosclerosis, this field is yet to be penetrated adequately by bibliometric studies. The Journal of Ethnopharmacology leads with the most publications and boasts the greatest total number of citations.
So far, researchers have focused on the significance of silicon for the development of bones and connective tissue, and its role in preventing neurodegenerative diseases and atherosclerosis. Despite numerous studies, the role of silicon as an active element in the human body is poorly understood.
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. percent Compound Annual Growth Rate (CAGR).
He is the author of over 150 articles, book chapters, abstracts and other publications on advanced imaging technologies. and journal article authors Udo Hoffman, M.D., 25, 2024 in the European Heart Journal Cardiovascular Imaging 1. Earls is a founding member and one of the first Fellows of the Society of Cardiovascular CT.
Exercise and Coronary Atherosclerosis | Circulation There are a few pieces of evidence, however, that can give endurance athletes some reassurance that they’re not headed to an early grave. For one, athletes live longer than the general population, with reductions in all-cause and cardiovascular disease mortality of about 30–40%.
As a side note, many Blue Zones are thought to be more a function of falsified or improper record keeping, but that’s an article for another day). Coronary atherosclerosis, as evidenced by an abnormal CAC score, is a measure of advanced plaque. Tsimane Tribe. This is FIVE FOLD less than the average Western population.
This modification will affect not only the onset of diabetes but also the related onset of atherosclerosis. Therefore, in this review, based on the whole process of atherosclerosis evolution, we explored the possible existence of acetylation/deacetylation caused by diabetes.
In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease.
Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated. Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated.
The goal of the INSPIRES trial was to determine whether DAPT with clopidogrel and aspirin initiated within 72 hours of mild ischemic stroke or high-risk TIA was associated with decreased incidence of recurrent stroke compared with aspirin monotherapy.
However, due to the distinct biological functions of ASCs from different origins or donors with varing health statuses (such as aging, diabetes, or atherosclerosis), the heterogeneity of ASCs deserves more attention. Exosomes from ASCs also play an indispensable role in this process.
The risk of atherosclerotic cardiovascular disease (ASCVD) is approximately twofold higher for South Asian (SA) adults than for adults from other racial and ethnic groups. Type 2 diabetes mellitus (T2DM) is a highly prevalent risk factor that likely contributes to this disparity.
The goal of the PACMAN-AMI trial was to demonstrate the efficacy of early administration of alirocumab on plaque characteristics among patients undergoing percutaneous coronary intervention (PCI) for an acute myocardial infarction (AMI).
Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. However, despite a heterogenous substrate underlying coronary thrombosis, treatment remains identical.
In this week’s View, Dr. Eagle looks at the clinical impact of early rhythm control and healthy lifestyles in patients with atrial fibrillation, then explores the use of low-dose aspirin in the prevention of atherosclerotic cardiovascular disease.
CiteSpace was used to analyze author and institution centroids, keyword bursts, and timeline graphs.ResultA total of 2,474 articles related to CVD and PCSK9 were included. The number of articles and citations show an increasing trend from year to year. Atherosclerosis was the most published journal. Watts, Gerald F.
In this article, we first describe how ERK signaling contributes to preserving cardiovascular health. We then summarize current knowledge of the roles played by ERK in the development and progression of cardiac and vascular disorders, including atherosclerosis, myocardial infarction, cardiac hypertrophy, heart failure, and aortic aneurysm.
This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellular models, reducing HDAC9 (histone deacetylase 9) protein is associated with reduced disease. Indirect data support such an approach in man.
The pooled mean percentage difference between the cardioembolic group and the large artery atherosclerosis /noncardioembolic group was 10.3% (95% CI 16.3% Of these, the pooled percentage difference of white blood cells between the cardioembolic group and the large artery atherosclerosis/noncardioembolic group was +1.1% (95% CI +0.3%
This article is part 2 of a series on cardiac CT. If you have not yet read it, I suggest doing so before reading the remainder of this article. I've included the article here. A CT CAC scan can only identify if there is calcified atherosclerosis, where it is and to what extent. And it matters.
Immune-mediated systemic inflammatory disorders (IMIDs) are associated with an increased risk of cardiovascular disease (CVD), ranging from atherosclerosis to myocarditis and heart failure.
Thicker carotid intima–media thickness (CIMT) has been a valid predictor for atherosclerosis development. Reference lists of retrieved articles were further scanned as to avoid any missing literatures. 331 articles were retrieved, and 4 were finally selected.
The fundamental characteristic of atherosclerosis is when a cholesterol particle becomes trapped in the artery wall. It is the inflammatory response to this particle retention that causes the formation of atherosclerosis 1. Lipoprotein particles entering the subintimal space causing atherosclerosis. CE = Cholesterol Ester.
Explore the CMHC Lipid Management Hub Visit the CMHC Lipid Management Hub , where you’ll find a wealth of resources, including webinars, CME activities, expert interviews, on-demand event recordings, news articles, drug pipelines, and more, all organized by specialty focus and format.
cobalt, copper, zinc) are associated with increased coronary artery calcification (CAC) and are comparable to traditional cardiovascular disease risk factors like smoking and diabetes, according to results from the Multi-Ethnic Study of Atherosclerosis (MESA) published in JACC. Urinary levels of non-essential (i.e.,
LDL is obviously a target against atherosclerosis. This LDL receptor regulatory chaperone , prevents recycling so blocking or reducing its function This cartoon from the Dr. Libby’s article (Ref. Preamble 15 % of body weight is fat. 10kg) Out of which just 250 mg of cholesterol is streaming in blood. Let us use it maximum.
One of the assessments for coronary atherosclerosis during cardiac computed tomography (CT) is coronary artery calcium (CAC) scoring. We conducted analysis on the determinants of high-risk coronary calcification, represented by CAC score, among women as a step to improve their outcomes and prognosis.
We included articles reporting patients > 18 years old with symptomatic extracranial vertebral artery stenoses due to atherosclerosis treated with stenting (with or without angioplasty). Those reporting patients with vertebral dissections were excluded.
In this week’s View, Dr. Eagle looks at a systematic review and meta-analysis of antibiotic prophylaxis and infective endocarditis incidence following invasive dental procedures. He then examines the issue of serious bleeding in patients with atrial fibrillation using diltiazem with apixaban or rivaroxaban.
ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; GRAM, GRaph-based Attention Model; PCP-HF, Pooled Cohort equations to Prevent Heart Failure; RETAIN, REverse Time AttentIoN model. Risk of bias was assessed using PROBAST. We included 36 studies with 59 prediction models.
Development and validation of a machine-learning approach to identify diabetic cardiomyopathy. In this study, we developed and validated a machine learning-based clustering approach to identify the high-risk DbCM phenotype based on echocardiographic and cardiac biomarker parameters.
A subsequent article will focus on the risk of late-onset dementia for those carriers of APOE4. Share For those with defective LDL receptors, as seen in familial hyperlipidemia, APOB particles are not cleared effectively, and concentrations rise, causing atherosclerosis 4. Which increases the risk of atherosclerosis.
Dysregulation of the innate and adaptive immune system is accelerated by CKD and results in increased systemic inflammation, a heightened local vascular inflammatory response leading to accelerated atherosclerosis, and dysfunction of the cardiac and renal endothelium and microcirculation.
Nonobstructive coronary disease by coronary angiography should be differentiated between patients with normal coronary arteries and minimal luminal irregularities (less than 30% stenosis) and mild to moderate coronary atherosclerosis (30% to less than 50%). FFR can be useful. A list of conditions that can cause this is below.
In a recent article (J Electrocardiol this year, see reference below), peak trop onin I levels in takotsubo presenting with ST Elevation were median 1.02 Note 2: This article fails to specify whether it was troponin I or T, but I contacted the institution and they used exclusively troponin I during that time period.
Share If you do not read any further, you will have come away with the main takeaway of this article. Atherosclerosis. I am going to start with the answer to the question of whether statins cause dementia and then provide the details backing up my answer. The answer is: No. Statins do not cause dementia. Curr Opin Lipidol.
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death worldwide, causing around 17.9 million deaths annually, a third of whom are adults aged <70 years. 3 Air pollution is a silent killer and was highlighted as a significant public health concern in the recently published European Society of Cardiology (ESC) guidelines.
Methods and results This study included 5548 non-active smoking participants aged 45–84 years and free of known cardiovascular diseases and HF at baseline who self-reported SHS exposure time in the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline (2000–2002).
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