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Abstract TMP112: Von Willebrand Factor (VWF) Modulates Smooth Muscle Cell Proliferation During the Outward Remodeling of Leptomeningeal Collateral Arterioles Following Stroke

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page ATMP112-ATMP112, February 1, 2024. Introduction:The leptomeningeal collaterals (LMCs) undergo outward remodeling after stroke to increase rescue flow toward the occluded region. In cohort 3, Ki67-positive SMCs were absent in the VWF-KOs at 3 days post-stroke. and 10.73 ± 1.26

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Abstract TMP5: The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATMP5-ATMP5, February 1, 2025. In penetrated arterioles, the expression of Bax in the SAH-nimodipine group was significantly lower than that of the SAH-saline group (p < 0.001).

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Abstract WP60: Orosomucoid Expression in Cerebral Amyloid Angiopathy

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWP60-AWP60, February 1, 2025. Background:Cerebral amyloid angiopathy (CAA), in which amyloid- (A) is deposited in cerebral and meningeal blood vessels, is associated with not only stroke but also cognitive dysfunction.

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Abstract WP297: Time-Dependent Effects of Drag-Reducing Polymers Administration on Permanent Middle Cerebral Artery Occlusion Injury in Rats

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page AWP297-AWP297, February 1, 2024. Introduction:Current treatments for ischemic stroke are not focused directly on cerebral microcirculation. Here we evaluated the dependence of DRPs efficiency on stroke outcome from the time of application.Methods:DRPs (2 μg/ml) or saline was i.v.

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Abstract TMP63: Genetic investigation for cerebral small vessel disease genes in patients with spontaneous intracerebral hemorrhage

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATMP63-ATMP63, February 1, 2025. Objectives:Spontaneous intracerebral hemorrhage (ICH) is caused by the rupture of small arterioles due to cerebral small vessel disease (SVD), commonly with hypertensive arteriolosclerosis (HTA) or cerebral amyloid angiopathy (CAA).

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Abstract TMP111: Perivascular von Willebrand factor (VWF) promotes irregular remodeling of leptomeningeal collaterals in response to sustained increased luminal flow.

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATMP111-ATMP111, February 1, 2025. We previously demonstrated abnormal deposition of VWF in themurallayer of leptomeningeal collateral arterioles (LMCs) during flow-induced outward remodeling. Introduction:VWF is an endothelial protein with known roles in hemostasis and thrombosis.

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Abstract 017: Rapid Progression Of Microhemorrhage In A Patient With An Atypical CADASIL Variant

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. The first panel evaluates 10 genes for variants which are associated with hereditary forms of cerebral small vessel disease, encompassing those conditions in which small arteries, arterioles, venules, and capillaries of the brain are compromised.