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Participants in the intervention group displayed less tortuous arterioles and venules and an increased arteriolar fractal dimension compared to the control group. These effects were evident even after controlling for cumulative cardiovascular risk factors.
Human resistance arterioles (80-250µm) from healthy adults (defined as patients with ≤1 risk factor for cardiovasculardisease) were dissected from discarded surgical adipose tissue and treated with empagliflozin (1µM), or vehicle control (ethanol) for 16-20 hours prior to the flow experiment.
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