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Abstract TMP112: Von Willebrand Factor (VWF) Modulates Smooth Muscle Cell Proliferation During the Outward Remodeling of Leptomeningeal Collateral Arterioles Following Stroke

Stroke Journal

Our findings also provide evidence for VWF within the smooth muscle layer of pig and human brain arterioles, supporting the broader potential role of VWF as a molecular player in vascular remodeling. Knockout of VWF resulted in reduced LMC remodeling and delayed SMC proliferation.

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Abstract TMP5: The Impact of Enteral Nimodipine on Endothelial Cell Apoptosis in an Animal Subarachnoid Hemorrhage Model

Stroke Journal

In penetrated arterioles, the expression of Bax in the SAH-nimodipine group was significantly lower than that of the SAH-saline group (p < 0.001). The thickness of the tunica media in the basilar artery was thinner in the SAH-nimodipine group than in the SAH-saline group (p < 0.001).Conclusions:This

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Lifelong dietary interventions linked to improved retinal health and reduced cardiovascular risk

Cardiology Update

Participants in the intervention group displayed less tortuous arterioles and venules and an increased arteriolar fractal dimension compared to the control group. Several lifelong cumulative cardiovascular risk factors, such as cumulative systolic blood pressure, were independently linked to narrower arterioles.

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Abstract WP60: Orosomucoid Expression in Cerebral Amyloid Angiopathy

Stroke Journal

In the comparison between the three groups, immunohistochemistry higher expression of orosomucoid in the arteries/ arterioles of CAA type1 than control group.

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Thrombin in Pregnancy and Preeclampsia: Expression, Localization and Vasoactivity in Brain and Microvessels from Rats

Journal of Cardiovascular Pharmacology

We characterized thrombin expression and vasoactivity in brain cerebral parenchymal arterioles (PAs) in rat models of pregnancy and PE. We characterized thrombin expression and vasoactivity in brain cerebral parenchymal arterioles (PAs) in rat models of pregnancy and PE.

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Abstract 4141446: Sodium Glucose Co-transporter 2 (SGLT2) Inhibitors Promote Resiliency to High Pressure Stress in the Human Microvasculature

Circulation

Human resistance arterioles (80-250µm) from healthy adults (defined as patients with ≤1 risk factor for cardiovascular disease) were dissected from discarded surgical adipose tissue and treated with empagliflozin (1µM), or vehicle control (ethanol) for 16-20 hours prior to the flow experiment.

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Abstract TMP111: Perivascular von Willebrand factor (VWF) promotes irregular remodeling of leptomeningeal collaterals in response to sustained increased luminal flow.

Stroke Journal

We previously demonstrated abnormal deposition of VWF in themurallayer of leptomeningeal collateral arterioles (LMCs) during flow-induced outward remodeling. Introduction:VWF is an endothelial protein with known roles in hemostasis and thrombosis. mg/ml at 1 ul/min; 5-7ul total).